A breakthrough in the catalytic enantioselective synthesis of allenes was recently reported by Hayashi and co-workers: chiral trichlorosilyl allenes were generated with up to 90 % ee by palladium-catalyzed hydrosilylation of but-1-en-3-ynes in the presence of a chiral ferrocenyl phosphane [Eq. (1)]. This transformation, as well as further recent highlights in enantioselective allene synthesis, are summarized in this account.

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Volume41, Issue16

August 16, 2002

Pages 2933-2935

Enantioselective Synthesis of and with Allenes

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