Enantioselective Synthesis of Kedarcidin Chromophore Aglycon in Differentially Protected Form
Andrew G. Myers Prof.
Department of Chemistry and Chemical Biology Harvard University Cambridge, Massachusetts 02138 (USA) Fax: (+1) 617-495-4976
Search for more papers by this authorPhilip C. Hogan
Department of Chemistry and Chemical Biology Harvard University Cambridge, Massachusetts 02138 (USA) Fax: (+1) 617-495-4976
Search for more papers by this authorAlexander R. Hurd
Department of Chemistry and Chemical Biology Harvard University Cambridge, Massachusetts 02138 (USA) Fax: (+1) 617-495-4976
Search for more papers by this authorSteven D. Goldberg
Department of Chemistry and Chemical Biology Harvard University Cambridge, Massachusetts 02138 (USA) Fax: (+1) 617-495-4976
Search for more papers by this authorAndrew G. Myers Prof.
Department of Chemistry and Chemical Biology Harvard University Cambridge, Massachusetts 02138 (USA) Fax: (+1) 617-495-4976
Search for more papers by this authorPhilip C. Hogan
Department of Chemistry and Chemical Biology Harvard University Cambridge, Massachusetts 02138 (USA) Fax: (+1) 617-495-4976
Search for more papers by this authorAlexander R. Hurd
Department of Chemistry and Chemical Biology Harvard University Cambridge, Massachusetts 02138 (USA) Fax: (+1) 617-495-4976
Search for more papers by this authorSteven D. Goldberg
Department of Chemistry and Chemical Biology Harvard University Cambridge, Massachusetts 02138 (USA) Fax: (+1) 617-495-4976
Search for more papers by this authorFinancial support from the National Institutes of Health is gratefully acknowledged. We thank Dr. Richard Staples and Mr. Andrew Haidle for the X-ray analysis of compound 20.
Graphical Abstract
Vier in Grammmengen hergestellte Komponenten wurden verknüpft bei der konvergenten (längste lineare Sequenz: 25 Stufen), enantioselektiven Synthese des komplementär geschützten Aglycons des Kedarcidin-Chromophors (1). Einer der Schlüsselschritte war eine transanulare anionisch induzierte Cyclisierung zum Bicyclo[7.3.0]dodecadiendiin-Gerüst in Gegenwart eines überbrückten Makrolactons. MOM=Methoxymethyl, TIPS=Triisopropylsilyl, TES=Triethylsilyl.
References
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