Antineoplastic and Immunomodulating Agents (L)
First published: 24 January 2022
Abstract
The article contains sections titled:
1 | Introduction |
2 | L01 Antineoplastic Agents |
2.1 | L01A Alkylating Agents |
2.1.1 | L01AA Nitrogen Mustard Analogues |
2.1.2 | L01AB Alkylsulfonates |
2.1.3 | L01AC Ethyleneimines (Aziridines) |
2.1.4 | L01AD Nitrosoureas |
2.1.5 | L01AX Other Alkylating Agents |
2.2 | L01B Antimetabolites |
2.2.1 | L01BA Folic Acid Analogues |
2.2.2 | L01BB Purine Analogues |
2.2.3 | L01BC Pyrimidine Analogues |
2.3 | L01C Plant Alkaloids and Other Natural Products |
2.3.1 | L01CA Vinca Alkaloids and Analogues |
2.3.2 | L01CB Podophyllotoxin Derivatives |
2.3.3 | L01CD Taxanes |
2.3.4 | L01CE Topoisomerase 1 (TOP 1) Inhibitors |
2.3.5 | L01CX Other Plant Alkaloids and Natural Products |
2.4 | L01D Cytotoxic Antibiotics and Related Substances |
2.4.1 | L01DA Actinomycins |
2.4.2 | L01DB Anthracyclines and Related Substances |
2.4.3 | L01DC Other Cytotoxic Antibiotics |
2.5 | L01E Protein Kinase Inhibitors |
2.5.1 | L01EA BcrAbl Tyrosine Kinase Inhibitors |
2.5.2 | L01EB Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors |
2.5.3 | L01EC B-Raf Serine–Threonine Kinase (BRAF) Inhibitors |
2.5.4 | L01ED Anaplastic Lymphoma Kinase (ALK) Inhibitors |
2.5.5 | L01EE Mitogen-Activated Protein Kinase (MEK) Inhibitors |
2.5.6 | L01EF Cyclin-Dependent Kinase (CDK) Inhibitors |
2.5.7 | L01EG Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors |
2.5.8 | L01EH Human Epidermal Growth Factor Receptor 2 (HER2) Tyrosine Kinase Inhibitors |
2.5.9 | L01EJ Janus-Associated Kinase (JAK) Inhibitors |
2.5.10 | L01EK Vascular Endothelial Growth Factor (VEGFR) Tyrosine Kinase Inhibitors |
2.5.11 | L01EL Bruton's Tyrosine Kinase (BTK) Inhibitors |
2.5.12 | L01EM Phosphatidylinositol-3-kinase (Pi3K) Inhibitors |
2.5.13 | L01EX Other Protein Kinase Inhibitors |
2.6 | L01X Other Antineoplastic Agents |
2.6.1 | L01XA Platinum Compounds |
2.6.2 | L01XB Methylhydrazines |
2.6.3 | L01XC Monoclonal Antibodies (MAbs or mAbs) |
2.6.4 | L01XD Sensitizers Used in Photodynamic/Radiation Therapy |
2.6.5 | L01XF Retinoids for Cancer Treatment |
2.6.6 | L01XG Proteasome Inhibitors |
2.6.7 | L01XH Histone Deacetylase (HDAC) Inhibitors |
2.6.8 | L01XJ Hedgehog Pathway Inhibitors |
2.6.9 | L01XK Poly (ADP-Ribose) Polymerase (PARP) Inhibitors |
2.6.10 | L01XX Other Antineoplastic Agents |
3 | L02 Endocrine Therapy |
3.1 | L02A Hormones and Related Agents |
3.1.1 | L02AA Estrogens |
3.1.2 | L02AB Progestogens (Gestagens) |
3.1.3 | L02AE Gonadotropin-Releasing Hormone Analogues |
3.2 | L02B Hormone Antagonists and Related Agents |
3.2.1 | L02BA Antiestrogens |
3.2.2 | L02BB Antiandrogens |
3.2.3 | L02BG Aromatase Inhibitors |
3.2.4 | L02BX Other Hormone Antagonists and Related Agents |
4 | Immune System and Its Modulation/Introduction |
5 | L03 Immunostimulants |
5.1 | L03A Immunostimulants |
6 | L04 Immunosuppressants |
6.1 | L04A Immunosuppressants |
6.1.1 | L04AA Selective Immunosuppressants |
6.1.2 | L04AB Monoclonal Antibodies/Tumor Necrosis Factor Alpha (TNF-α) Inhibitors |
6.1.3 | L04AC Monoclonal Antibodies/Interleukin Inhibitors |
6.1.4 | L04AD Calcineurin inhibitors |
6.1.5 | L04AX Other Immunosuppressants |
Abbreviations | |
References |
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Further Reading
- Adams, J.L., et al. (2015) Big Opportunities for Small Molecules in Immune-Oncology, Nat. Rev. Drug Discov. 14, 603–622.
- Airley, R. (2009) Cancer Chemotherapy, Wiley-Blackwell, Chichester.
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- Dobbelstein, M. and Moll, U. (2014) Targeting Tumour-Supportive Cellular Machineries in Anticancer Drug Development, Nat. Rev. Drug Discov. 13, 179–196. (Review regarding also the history of cancer therapies).
- IMS Institute for Healthcare Informatics: (a) Global Oncology Trend Report, May 2015 (Development in cancer treatments, market dynamics, patient access and value); (b) Global Oncology Trend Report, June 2016 (A review of 2015 and outlook to 2020).
- Manley, P.W., et al. (2015) Progress into the era of genomically targeted cancer drugs: 50 years of anticancer medicinal chemistry, in Medicinal Chemistry Reviews, vol. 50, Med. Chem. Division of the ACS; (a) Chapter 8, p. 187–223: Targeting Protein kinases, Lipid kinases, Protein-Protein interactions regulating apoptosis, aberrant DNA methylation, Histones, Hormones and hormone receptors, RAS. (b) Chapter 9, p. 225–237: Targeting the B-cell receptor pathway in hematological malignancies with Btk inhibitors, PI3Kδ inhibitors, Syk inhibitors.
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