This chapter contains sections titled:

• Nociception: Physiological Process

• Transmission of the Nociceptive Stimulus

• Nociceptors

• Chemical Mediators Involved in Nociception

• Expression and Localization of Prostaglandins, Prostaglandin Receptors and Cyclooxygenases Implicate Prostanoids in Nociception

• The Role of Prostaglandins in Inflammatory Pain

• Induction of COX-2 and Increased Prostaglandin Synthesis During Inflammation

• Role of Prostaglandins in Sensitizing Nerve Endings and Peripheral Nerve Fibres

• Prostaglandins Involved in the Maintenance of Pain

• References