Volume 38, Issue 13-14 pp. 1949-1952
Communication

Peptide Mini-Vectors for Gene Delivery

Robert G. Cooper

Robert G. Cooper

The Imperial College Genetic Therapies Centre Department of Chemistry, Imperial College of Science, Technology & Medicine, South Kensington, London SW7 2AY (UK), Fax: (+44) 171-594-5803

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Richard P. Harbottle

Richard P. Harbottle

Cystic Fibrosis Gene Therapy Research Group, Molecular Genetics Division of Biomedical Sciences, Imperial College School of Medicine (UK)

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Holm Schneider

Holm Schneider

Cystic Fibrosis Gene Therapy Research Group, Molecular Genetics Division of Biomedical Sciences, Imperial College School of Medicine (UK)

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Charles Coutelle

Charles Coutelle

Cystic Fibrosis Gene Therapy Research Group, Molecular Genetics Division of Biomedical Sciences, Imperial College School of Medicine (UK)

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Andrew D. Miller

Andrew D. Miller

The Imperial College Genetic Therapies Centre Department of Chemistry, Imperial College of Science, Technology & Medicine, South Kensington, London SW7 2AY (UK), Fax: (+44) 171-594-5803

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Abstract

The effective treatment of diseases by gene therapy may be a step nearer with the synthesis of two new peptide-based vectors for the delivery of genes to cells. A combination of two peptides—one containing an Arg-Gly-Asp integrin-binding motif, the other a fusogenic moiety—delivers genes almost as effectively as cationic liposomes.

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