We have shown that the readily prepared (ferrocenyl)benzylic methyl ethers of type 1 can be ortho-metalated with tert-BuLi with high diastereoselectivity. This reaction has been used to prepare new borane-protected P,N-substituted ferrocenes of type 2 in high diastereomeric and enantiomeric purity. The chiral heterocyclic aminophosphines 2 may be of interest as chelating ligands for asymmetric metal catalysis. Chirality 12:389–395, 2000. © 2000 Wiley-Liss, Inc.

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Volume12, Issue5-6

SPECIAL COMMEMORATIVE ISSUE HONORING PROFESSOR RYOJI NOYORI

2000

Pages 389-395

Preparation of new chiral borane-protected P,N-ferrocenyl ligands via a methoxy directed ortho-lithiation

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Preparation of new chiral borane-protected P,N-ferrocenyl ligands via a methoxy directed ortho-lithiation

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