After exposure to EE in APP/PS1 mice at the early stage of 2 months of age, the elevated plus maze and context fear condition were tested in those mice, followed by the observation of neurogenesis and activation extent in hippocampus. The results indicate that the activation of newborn neurons may participate in the improvement of behavioral performance in APP/PS1 mice after EE.

The significance of this study is to discover people with abnormal expression of AKT1, PRDM4, and BAX have lower PET and tend to commit abnormal behavior more easily. Understanding the PET will enable people to make self-adjustment or to intervene by professionals as soon as possible and in a timely manner in the face of various negative stimuli in work and life, especially for people with lower PET, people should intervene as early as possible to reduce the harm to the individual, family, and society.

In this manuscript, we firstly reported that the application of dexmedetomidine (starting at 0.5 μg/kg for 10 min followed by adjustment to 0.6 μg kg⁻¹ hr⁻¹ throughout the surgical procedure) could reduce both the consumption of total dose of nimodipine and sufentanil 48 hr after surgery and the prevalence of symptomatic cerebral vasospasm as well as increase the stability of hemodynamics. However, there were no significant differences among the three groups in terms of Glasgow coma scale and functional activity score during the first 48 hr after surgery, Glasgow Outcome Score at 3 months, or cerebral infarction after 30 days.

Pregnancy influences the pharmacokinetics of lamotrigine. A reduction in ratio to target concentration (RTC) leads to worsening seizures. RTC < 0.64 was a predictor of deteriorating seizures. A dosage adjustment is necessary for pregnant women when RTC < 0.64.

We reported a Chinese male patient of adult-onset leukodystrophy. Genetic examinations identified a homozygous mutation, c. 452T>C (p. M151T), in alanyl-tRNA synthetase 2 (AARS2) in the patient. We also reviewed phenotypic spectra of AARS2 mutation-associated leukodystrophies from a total of 16 reported cases.

Mental fatigue, as part of cognitive dysfunction, has been reported to be common after aneurysmal subarachnoid hemorrhage and it significantly affects quality of life. The Mental Fatigue Scale score was significantly correlated to the Extended Glasgow Outcome Scale (GOSE) score. Patients with GOSE 5-7 could benefit from assessments of mental fatigue in order to receive satisfactory rehabilitation.

Factors such as ischemia, hypoxia, reperfusion injury, and internal environment disturbance caused by deep hypothermic circulatory arrest during surgery lead to severe damage to various organs. Intraoperative ΔrSO2min that is lower than the basal level of about 80%, advanced age, preoperative low platelet, and prolonged hemostasis are predictors of PND after aortic total arch replacement.

This article investigates potential differences between physicians and nurse practitioners in CLZ underprescription and solutions. It was found that most reasons align between the physicians and nurse practitioners but there are differences that should be taken into account during future research and implementation of solutions to reduce CLZ underprescription.

Chronic binge alcohol exposure during pregnancy dysregulates fetal hippocampal gene expression in a sex-specific manner. Identification of subtle, transcriptome-level dysregulation in hippocampal molecular pathways offers potential mechanistic insights underlying FASD pathogenesis.

The appreciation of landscape gardens and natural landscapes relies on common cortical regions, and suggest the possibility that the inferior occipital lobe, the superior parietal lobule, the fusiform gyrus, and the cuneus may be specifically associated with the appreciation of landscape gardens.

We discovered two fragile X-associated tremor/ataxia syndrome patients by screening a carefully selected group of patients with essential tremor and additional mild cerebellar signs or extrapyramidal signs. Our result proposes a new group of patients for which testing of FMR1 premutation should be considered.

Olfactory and memory scores can differentiate Alzheimer's disease (AD) from mild cognitive impairment (MCI). Neurodegeneration, as measured by hippocampus and primary olfactory cortex (POC) volume is similar in AD and MCI. Patterns of ON activation support compensatory mechanisms in MCI and not in AD. DMN suppression during olfactory processing is impaired in AD. Effective connectivity between DMN and ON, in a model of causal influence, is impaired in AD.

The dysregulation of these six genes may involve with the process of ischemic stroke (IS). Four transcription factors (PAX4, POU2F1, ELK1, and NKX2-5) were concluded to play a role in IS. Our finding provided clues for exploring mechanism and developing novel diagnostic and therapeutic strategies for IS.

We performed a prospective study, including 110 multiple sclerosis patients, with repetitive testing of anti-John Cunningham virus (JCV) antibodies in predefined testing intervals. We were able to show that with testing of anti-JCV antibodies three times within short-term intervals seroconversion/-reversion due to assay variability can be indentified early, while real seroconversion due to a new infection with JCV is rare within an observational period of 1 year.

Differences in accuracy of NMOSD diagnosis, completeness of case ascertainment and variability in assays for AQP4-IgG affect epidemiological studies of NMOSD. Data from two epidemiological studies in two decades from Denmark reflect the complexity. The increased recognition of NMOSD may facilitate prospective epidemiological studies with standardized methodologies that will enable specific conclusions.

We evaluated the association of polymorphisms of 5-HTR2A gene with eating disorders in Mexican population. We found an association of rs6311 (A1438G) polymorphism of 5-HTR2A gene with eating disorders. The rs6311 could increase the risk of psychiatric comorbidities in patient with eating disorders.

In this study a group of workers exposed to occupational stress and suffering from Adjustment Disorders (AD) exhibited plasma BDNF levels significantly higher than those of healthy controls. In patients but not in controls plasma BDNF levels showed a significant positive correlation with serum cortisol levels. BDNF could play a key role in the pathophysiology of stress-related disorders and its peripheral levels elevation could contribute to protect neurons under stress. Further research is needed focusing on biomarkers for stress-related disorders as a potential tool for the diagnosis and prevention of occupational diseases.

The effect of video consultations is noninferior to traditional consultations in managing medication overuse headache (MOH) patients. Using video may be a good alternative in consulting patients with MOH.

In this study, we established hydrogen peroxide (H₂O₂) induced Leucine166Proline (L166P) and C106S DJ-1-transfected neuroblastoma (SH-SY5Y) cellular models of Parkinson's disease (PD) and investigated the effects of Cistanche extracts, including acteoside, echinacoside, caffeic acid, and Cistanche total glycosides on these two models. We successfully established sensitive and stable H₂O₂ induced L166P DJ-1- and C106S DJ-1-transfected SH-SY5Y cell models of PD and Cistanche extracts may thus be useful for treating PD.