To control diabetes epidemic and NCDs, WHO has been promoting its action plans since 2000, but diabetes epidemic is continuing. New action plan for 2013-2020 aim to reduce shared risk factors of NCDs, such as tobacco use, unhealthy (i.e., high fat) diet, physical inactivity and harmful use of alcohol and is strengthening the risk reduction measures, such as taxing on tobacco, alcohol and sugary beverages, banning advertisements of unhealthy foods. However it might fail because it did not consider the contribution of environmental pollution on the pathogenesis of diabetes and NCDs.

Although several pathological mechanisms responsible for diabetic cardiomyopathy have been proposed, oxidative stress is widely considered as one of the major causes for the pathogenesis of the disease. Hyperglycemia-, hyperlipidelima-, hypertension-, and inflammation-induced oxidative stress is a major risk factor for the development of micro-vascular pathogenesis in the diabetic myocardium, which results in abnormal gene expression, altered signal transduction, and the activation of pathways leading to programmed myocardial cell deaths.