Cover Picture

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Cover Picture: ConSurf: Using Evolutionary Data to Raise Testable Hypotheses about Protein Function / JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia (Isr. J. Chem. 3-4/2013)

  • Page: 137
  • First Published: 15 April 2013
Cover Picture: ConSurf: Using Evolutionary Data to Raise Testable Hypotheses about Protein Function / JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia (Isr. J. Chem. 3-4/2013)

The cover shows on the left a ConSurf analysis of the influenza neuraminidase protein. The 3D tetramer colored by conservation grades is shown in (A) with maroon indicating the most conserved amino acids, and close-up views (B,C) are shown of one of the conserved regions with the anti-flu drug, oseltamivir (tamiflu) bound; see Celniker et al. for details, page 199. On the right is a page from Proteopedia as viewed on an iPad, via the JSmol viewer, showing a complex of HIV-Protease and Saquinavir (Invirase), the first protease inhibitor approved by the FDA for the treatment of HIV; see Hanson et al. for details, page 207

Contents

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Contents: Isr. J. Chem. 3-4/2013

  • Page: 141
  • First Published: 15 April 2013

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