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    2016
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Clinical Study
Open Access

Ophthalmologic Baseline Characteristics and 2-Year Ophthalmologic Safety Profile of Pramipexole IR Compared with Ropinirole IR in Patients with Early Parkinson’s Disease

William Seiple,  Danna Jennings,  Richard B. Rosen,  Leona Borchert,  Lee Canale,  Nora Fagan,  Mark Forrest Gordon, 
  • First Published: 18 December 2016
Research Article
Open Access

A Case-Control Association Study of RANTES (-28C>G) Polymorphism as a Risk Factor for Parkinson’s Disease in Isparta, Turkey

Nilufer Sahin-Calapoglu,  Serpil Demirci,  Mustafa Calapoglu,  Baris Yasar, 
  • First Published: 18 December 2016
Review Article
Open Access

Parkinson’s Disease and Cognitive Impairment

Yang Yang,  Bei-sha Tang,  Ji-feng Guo, 
  • First Published: 12 December 2016
Review Article
Open Access

An Integrated Review of Psychological Stress in Parkinson’s Disease: Biological Mechanisms and Symptom and Health Outcomes

Kim Wieczorek Austin,  Suzanne Weil Ameringer,  Leslie Jameleh Cloud, 
  • First Published: 12 December 2016
Research Article
Open Access

Event-Related Potentials in Parkinson’s Disease Patients with Visual Hallucination

Yang-Pei Chang,  Yuan-Han Yang,  Chiou-Lian Lai,  Li-Min Liou, 
  • First Published: 08 December 2016
Research Article
Open Access

Abdominal Massage for the Relief of Constipation in People with Parkinson’s: A Qualitative Study

D. McClurg,  K. Walker,  P. Aitchison,  K. Jamieson,  L. Dickinson,  L. Paul,  S. Hagen,  A.-L. Cunnington, 
  • First Published: 08 December 2016
Review Article
Open Access

Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments

Andrée-Anne Poirier,  Benoit Aubé,  Mélissa Côté,  Nicolas Morin,  Thérèse Di Paolo,  Denis Soulet, 
  • First Published: 06 December 2016
Research Article
Open Access

Deep Brain Stimulation Frequency of the Subthalamic Nucleus Affects Phonemic and Action Fluency in Parkinson’s Disease

Valéria de Carvalho Fagundes,  Carlos R. M. Rieder,  Aline Nunes da Cruz,  Bárbara Costa Beber,  Mirna Wetters Portuguez, 
  • First Published: 05 December 2016
Review Article
Open Access

Marijuana Compounds: A Nonconventional Approach to Parkinson’s Disease Therapy

Mariana Babayeva,  Haregewein Assefa,  Paramita Basu,  Sanjeda Chumki,  Zvi Loewy, 
  • First Published: 05 December 2016
Research Article
Open Access

Aerobic Exercise Preserves Olfaction Function in Individuals with Parkinson’s Disease

Anson B. Rosenfeldt,  Tanujit Dey,  Jay L. Alberts, 
  • First Published: 23 November 2016
Research Article
Open Access

Blood Plasma of Patients with Parkinson’s Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity

Peng Wang,  Xin Li,  Xuran Li,  Weiwei Yang,  Shun Yu, 
  • First Published: 14 November 2016
Research Article
Open Access

Median and Ulnar Neuropathy Assessment in Parkinson’s Disease regarding Symptom Severity and Asymmetry

Nilgul Yardimci,  Ozlem Cemeroglu,  Eda Ozturk,  Gülsüm Gürlü,  Esra Şahin,  Saliha Bozkurt,  Tugba Cengiz,  Gulderen Karali,  Hasim Cakirbay,  Atilla İlhan, 
  • First Published: 24 October 2016
Review Article
Open Access

Classification and Characteristics of Pain Associated with Parkinson’s Disease

Marcelo Rezende Young Blood,  Marcelo Machado Ferro,  Renato Puppi Munhoz,  Hélio Afonso Ghizoni Teive,  Carlos Henrique Ferreira Camargo, 
  • First Published: 05 October 2016
Research Article
Open Access

Patients’ Views on a Combined Action Observation and Motor Imagery Intervention for Parkinson’s Disease

Judith Bek,  Jordan Webb,  Emma Gowen,  Stefan Vogt,  Trevor J. Crawford,  Matthew S. Sullivan,  Ellen Poliakoff, 
  • First Published: 29 September 2016
Review Article
Open Access

Brain MR Contribution to the Differential Diagnosis of Parkinsonian Syndromes: An Update

Giovanni Rizzo,  Stefano Zanigni,  Roberto De Blasi,  Daniela Grasso,  Davide Martino,  Rodolfo Savica,  Giancarlo Logroscino, 
  • First Published: 28 September 2016
Research Article
Open Access

N-Acetylcysteine in Combination with IGF-1 Enhances Neuroprotection against Proteasome Dysfunction-Induced Neurotoxicity in SH-SY5Y Cells

Benxu Cheng,  Pinki Anand,  Anxiu Kuang,  Feroz Akhtar,  Virginia L. Scofield, 
  • First Published: 28 September 2016
Review Article
Open Access

Mini Review: Anticholinergic Activity as a Behavioral Pathology of Lewy Body Disease and Proposal of the Concept of “Anticholinergic Spectrum Disorders”

Koji Hori,  Kimiko Konishi,  Misa Hosoi,  Hiroi Tomioka,  Masayuki Tani,  Yuka Kitajima,  Mitsugu Hachisu, 
  • First Published: 22 September 2016
Research Article
Open Access

Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3K/Akt/GSK3β Pathway

Wei Zhang,  Hong He,  Hujie Song,  Junjie Zhao,  Tao Li,  Leitao Wu,  Xiaojun Zhang,  Jianzong Chen, 
  • First Published: 21 September 2016
Research Article
Open Access

Analysis of LRRK2, SNCA, and ITGA8 Gene Variants with Sporadic Parkinson’s Disease Susceptibility in Chinese Han Population

Jie Fang,  Kehui Yi,  Mingwei Guo,  Xingkai An,  Hongli Qu,  Qing Lin,  Min Bi,  Qilin Ma, 
  • First Published: 07 September 2016
Review Article
Open Access

Cognitive Training in Parkinson’s Disease: A Review of Studies from 2000 to 2014

Daniel Glizer,  Penny A. MacDonald, 
  • First Published: 05 September 2016
Research Article
Open Access

Parkinson’s Disease and Homocysteine: A Community-Based Study in a Folate and Vitamin B12 Deficient Population

Zhang Wei,  Wang Tiandong,  Li Yang,  Meng Huaxing,  Min Guowen,  Fang Yalan,  Niu Xiaoyuan, 
  • First Published: 31 August 2016
Research Article
Open Access

Outlining a Population “at Risk” of Parkinson’s Disease: Evidence from a Case-Control Study

Tommaso Schirinzi,  Giuseppina Martella,  Alessio D’Elia,  Giulia Di Lazzaro,  Paola Imbriani,  Graziella Madeo,  Leonardo Monaco,  Marta Maltese,  Antonio Pisani, 
  • First Published: 29 August 2016
Research Article
Open Access

Drosophila Mutant Model of Parkinson’s Disease Revealed an Unexpected Olfactory Performance: Morphofunctional Evidences

Francescaelena De Rose,  Valentina Corda,  Paolo Solari,  Patrizia Sacchetti,  Antonio Belcari,  Simone Poddighe,  Sanjay Kasture,  Paolo Solla,  Francesco Marrosu,  Anna Liscia, 
  • First Published: 28 August 2016
Research Article
Open Access

The Effect of Hyperhomocysteinemia on Motor Symptoms, Cognitive Status, and Vascular Risk in Patients with Parkinson’s Disease

Bilge Kocer,  Hayat Guven,  Isik Conkbayir,  Selim Selcuk Comoglu,  Sennur Delibas, 
  • First Published: 25 August 2016
Review Article
Open Access

Alpha-Synuclein in Parkinson’s Disease: From Pathogenetic Dysfunction to Potential Clinical Application

Lingjia Xu,  Jiali Pu, 
  • First Published: 17 August 2016
Research Article
Open Access

The Cognition of Maximal Reach Distance in Parkinson’s Disease

Satoru Otsuki,  Masanori Nagaoka, 
  • First Published: 15 August 2016
Editorial
Open Access

Mitochondria: Key Organelle in Parkinson’s Disease

Rubén Gómez-Sánchez,  José M. Bravo-San Pedro,  Matthew E. Gegg,  Rosa A. González-Polo,  José M. Fuentes, 
  • First Published: 07 August 2016
Research Article
Open Access

5-HT2A Receptor Binding in the Frontal Cortex of Parkinson’s Disease Patients and Alpha-Synuclein Overexpressing Mice: A Postmortem Study

Nadja Bredo Rasmussen,  Mikkel Vestergaard Olesen,  Tomasz Brudek,  Per Plenge,  Anders Bue Klein,  Jenny E. Westin,  Karina Fog,  Gitta Wörtwein,  Susana Aznar, 
  • First Published: 04 August 2016
Research Article
Open Access

Comparison of Test Your Memory and Montreal Cognitive Assessment Measures in Parkinson’s Disease

Emily J. Henderson,  Howard Chu,  Daisy M. Gaunt,  Alan L. Whone,  Yoav Ben-Shlomo,  Veronica Lyell, 
  • First Published: 05 July 2016
Editorial
Open Access

Parkinson’s Disease: New Insights into Pathophysiology and Rehabilitative Approaches

Vincenza Frisardi,  Andrea Santamato,  Binith Cheeran, 
  • First Published: 30 June 2016
Research Article
Open Access

Goal Setting for Cognitive Rehabilitation in Mild to Moderate Parkinson’s Disease Dementia and Dementia with Lewy Bodies

Tamlyn J. Watermeyer,  John V. Hindle,  Julie Roberts,  Catherine L. Lawrence,  Anthony Martyr,  Huw Lloyd-Williams,  Andrew Brand,  Petra Gutting,  Zoe Hoare,  Rhiannon Tudor Edwards,  Linda Clare, 
  • First Published: 29 June 2016
Research Article
Open Access

Altered Spontaneous Brain Activity in Cortical and Subcortical Regions in Parkinson’s Disease

Jie Xiang,  Xiuqin Jia,  Huizhuo Li,  Jiawei Qin,  Peipeng Liang,  Kuncheng Li, 
  • First Published: 19 June 2016
Review Article
Open Access

Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson’s Disease

Ruixin Yang,  Guodong Gao,  Zixu Mao,  Qian Yang, 
  • First Published: 16 June 2016
Research Article
Open Access

Evaluation of Nonmotor Symptoms in Diagnosis of Parkinsonism and Tremor

Andrew H. Evans,  Chiun-Hian Chai, 
  • First Published: 14 June 2016
Research Article
Open Access

The Association between C9orf72 Repeats and Risk of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis: A Meta-Analysis

Li Shu,  Qiying Sun,  Yuan Zhang,  Qian Xu,  Jifeng Guo,  Xinxiang Yan,  Beisha Tang, 
  • First Published: 08 June 2016
Review Article
Open Access

Pathophysiology of Motor Dysfunction in Parkinson’s Disease as the Rationale for Drug Treatment and Rehabilitation

Francesca Magrinelli,  Alessandro Picelli,  Pierluigi Tocco,  Angela Federico,  Laura Roncari,  Nicola Smania,  Giampietro Zanette,  Stefano Tamburin, 
  • First Published: 06 June 2016
Research Article
Open Access

Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy

Ruwei Ou,  Wei Song,  Qianqian Wei,  Ke Chen,  Bei Cao,  Yanbing Hou,  Bi Zhao,  Huifang Shang, 
  • First Published: 05 June 2016
Research Article
Open Access

Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation

Dina Morshedi,  Mahour Nasouti, 
  • First Published: 24 May 2016
Research Article
Open Access

Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson’s Disease

Qi Xu,  Anumantha G. Kanthasamy,  Huajun Jin,  Manju B. Reddy, 
  • First Published: 19 May 2016
Review Article
Open Access

Can a Positive Allosteric Modulation of GABAergic Receptors Improve Motor Symptoms in Patients with Parkinson’s Disease? The Potential Role of Zolpidem in the Treatment of Parkinson’s Disease

Antonio Daniele,  Francesco Panza,  Antonio Greco,  Giancarlo Logroscino,  Davide Seripa, 
  • First Published: 17 May 2016
Review Article
Open Access

Parkinson’s Disease: The Mitochondria-Iron Link

Yorka Muñoz,  Carlos M. Carrasco,  Joaquín D. Campos,  Pabla Aguirre,  Marco T. Núñez, 
  • First Published: 17 May 2016
Clinical Study
Open Access

Impact of Sex on the Nonmotor Symptoms and the Health-Related Quality of Life in Parkinson’s Disease

Márton Kovács,  Attila Makkos,  Zsuzsanna Aschermann,  József Janszky,  Sámuel Komoly,  Rita Weintraut,  Kázmér Karádi,  Norbert Kovács, 
  • First Published: 16 May 2016
Research Article
Open Access

Relationships among Depression, Anxiety, Sleep, and Quality of Life in Patients with Parkinson’s Disease in Taiwan

Jun-Yu Fan,  Bao-Luen Chang,  Yih-Ru Wu, 
  • First Published: 15 May 2016
Review Article
Open Access

Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease

Katharina E. Rosenbusch,  Arjan Kortholt, 
  • First Published: 12 May 2016
Research Article
Open Access

An Expert Diagnosis System for Parkinson Disease Based on Genetic Algorithm-Wavelet Kernel-Extreme Learning Machine

Derya Avci,  Akif Dogantekin, 
  • First Published: 05 May 2016
Research Article
Open Access

Dysautonomia Differentially Influences the Effect of Affective Pain Perception on Quality of Life in Parkinson’s Disease Patients

D. Rada,  J. Seco,  E. Echevarría,  B. Tijero,  L. C. Abecia,  J. C. Gómez-Esteban, 
  • First Published: 28 April 2016
Research Article
Open Access

Association Analysis of NALCN Polymorphisms rs1338041 and rs61973742 in a Chinese Population with Isolated Cervical Dystonia

Qingqing Zhou,  Jing Yang,  Bei Cao,  Yongping Chen,  Qianqian Wei,  Ruwei Ou,  Wei Song,  Bi Zhao,  Ying Wu,  Huifang Shang, 
  • First Published: 28 April 2016
Research Article
Open Access

Reliability of Three Disability Scales for Detection of Independence Loss in Parkinson’s Disease

Anders Bjornestad,  Ole-Bjorn Tysnes,  Jan Petter Larsen,  Guido Alves, 
  • First Published: 24 April 2016
Research Article
Open Access

Nonmotor Features in Parkinson’s Disease: What Are the Most Important Associated Factors?

Liis Kadastik-Eerme,  Mari Muldmaa,  Stella Lilles,  Marika Rosenthal,  Nele Taba,  Pille Taba, 
  • First Published: 19 April 2016
Review Article
Open Access

Structural Neuroimaging Markers of Cognitive Decline in Parkinson’s Disease

Alexandru Hanganu,  Oury Monchi, 
  • First Published: 14 April 2016
Research Article
Open Access

Whole-Brain Atrophy Rate in Idiopathic Parkinson’s Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy

C. Guevara,  K. Bulatova,  G. J. Barker,  G. Gonzalez,  N. Crossley,  M. J. Kempton, 
  • First Published: 14 April 2016
Review Article
Open Access

Quantitative EEG and Cognitive Decline in Parkinson’s Disease

Vitalii V. Cozac,  Ute Gschwandtner,  Florian Hatz,  Martin Hardmeier,  Stephan Rüegg,  Peter Fuhr, 
  • First Published: 11 April 2016
Research Article
Open Access

Mindfulness for Motor and Nonmotor Dysfunctions in Parkinson’s Disease

Nadeeka N. W. Dissanayaka,  Farah Idu Jion,  Nancy A. Pachana,  John D. O’Sullivan,  Rodney Marsh,  Gerard J. Byrne,  Paul Harnett, 
  • First Published: 10 April 2016
Review Article
Open Access

Levodopa-Induced Dyskinesia Is Related to Indirect Pathway Medium Spiny Neuron Excitotoxicity: A Hypothesis Based on an Unexpected Finding

Svetlana A. Ivanova,  Anton J. M. Loonen, 
  • First Published: 06 April 2016
Research Article
Open Access

Subjective Visual Vertical in PD Patients with Lateral Trunk Flexion

F. Gandor,  D. Basta,  D. Gruber,  W. Poewe,  G. Ebersbach, 
  • First Published: 17 March 2016
Research Article
Open Access

Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2

Shaun Martin,  Sarah van Veen,  Tine Holemans,  Seyma Demirsoy,  Chris van den Haute,  Veerle Baekelandt,  Patrizia Agostinis,  Jan Eggermont,  Peter Vangheluwe, 
  • First Published: 17 March 2016
Research Article
Open Access

Altered Mitochondrial Respiration and Other Features of Mitochondrial Function in Parkin-Mutant Fibroblasts from Parkinson’s Disease Patients

William Haylett,  Chrisna Swart,  Francois van der Westhuizen,  Hayley van Dyk,  Lize van der Merwe,  Celia van der Merwe,  Ben Loos,  Jonathan Carr,  Craig Kinnear,  Soraya Bardien, 
  • First Published: 08 March 2016
Research Article
Open Access

A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain

Rachit Bakshi,  Shuchi Mittal,  Zhixiang Liao,  Clemens R. Scherzer, 
  • First Published: 03 March 2016
Research Article
Open Access

Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis

Georg Auburger,  Suzana Gispert,  Nadine Brehm, 
  • First Published: 01 March 2016
Research Article
Open Access

Using Tractography to Distinguish SWEDD from Parkinson’s Disease Patients Based on Connectivity

Mansu Kim,  Hyunjin Park, 
  • First Published: 29 February 2016
Clinical Study
Open Access

Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-l-m-tyrosine Uptake in the Locus Coeruleus

Sayaka Asari Ono,  Toshihiko Sato,  Shin-ichi Muramatsu, 
  • First Published: 23 February 2016
Research Article
Open Access

Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease

Thuong Manh Le,  Koji Hashida,  Hieu Minh Ta,  Mika Takarada-Iemata,  Koichi Kokame,  Yasuko Kitao,  Osamu Hori, 
  • First Published: 23 February 2016
Research Article
Open Access

Insula Volume and Salience Network Are Associated with Memory Decline in Parkinson Disease: Complementary Analyses of Voxel-Based Morphometry versus Volume of Interest

Yan-Ting Lu,  Wen-Neng Chang,  Chiung-Chih Chang,  Cheng-Hsien Lu,  Nai-Ching Chen,  Chi-Wei Huang,  Wei-Che Lin,  Ya-Ting Chang, 
  • First Published: 21 February 2016
Research Article
Open Access

National Trends of Antiparkinsonism Treatment in Taiwan: 2004–2011

Weng-Ming Liu,  Ruey-Meei Wu,  Chia-Hsuin Chang,  Jou-Wei Lin,  Ying-Chun Liu,  Chin-Hsien Lin, 
  • First Published: 18 February 2016
Research Article
Open Access

Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson’s Disease

Kawinthra Khwanraj,  Suriyat Madlah,  Khwanthana Grataitong,  Permphan Dharmasaroja, 
  • First Published: 14 February 2016
Clinical Study
Open Access

Rotigotine Objectively Improves Sleep in Parkinson’s Disease: An Open-Label Pilot Study with Actigraphic Recording

Giovanna Calandra-Buonaura,  Pietro Guaraldi,  Andrea Doria,  Stefano Zanigni,  Stefania Nassetti,  Valentina Favoni,  Sabina Cevoli,  Federica Provini,  Pietro Cortelli, 
  • First Published: 14 February 2016
Research Article
Open Access

Blindfolded Balance Training in Patients with Parkinson’s Disease: A Sensory-Motor Strategy to Improve the Gait

M. Tramontano,  S. Bonnì,  A. Martino Cinnera,  F. Marchetti,  C. Caltagirone,  G. Koch,  A. Peppe, 
  • First Published: 09 February 2016
Review Article
Open Access

Genetic Profile, Environmental Exposure, and Their Interaction in Parkinson’s Disease

Letizia Polito,  Antonio Greco,  Davide Seripa, 
  • First Published: 31 January 2016
Clinical Study
Open Access

Postural Stability in Parkinson’s Disease Patients Is Improved after Stochastic Resonance Therapy

Oliver Kaut,  Daniel Brenig,  Milena Marek,  Niels Allert,  Ullrich Wüllner, 
  • First Published: 26 January 2016
Research Article
Open Access

Risk Factors of Fatigue in Idiopathic Parkinson’s Disease in a Polish Population

Monika Gołąb-Janowska,  Dariusz Kotlęga,  Krzysztof Safranow,  Agnieszka Meller,  Anna Budzianowska,  Krystyna Honczarenko, 
  • First Published: 26 January 2016
Research Article
Open Access

Variations in Incidence and Prevalence of Parkinson’s Disease in Taiwan: A Population-Based Nationwide Study

Chih-Ching Liu,  Chung-Yi Li,  Pei-Chen Lee,  Yu Sun, 
  • First Published: 19 January 2016
Research Article
Open Access

Clinical Pain and Neuropsychological Functioning in Parkinson’s Disease: Are They Related?

Gwenda Engels,  Wouter D. Weeda,  Annemarie M. M. Vlaar,  Henry C. Weinstein,  Erik J. A. Scherder, 
  • First Published: 13 January 2016
Research Article
Open Access

Abnormal Echogenicity of the Substantia Nigra, Raphe Nuclei, and Third-Ventricle Width as Markers of Cognitive Impairment in Parkinsonian Disorders: A Cross-Sectional Study

Angela E. P. Bouwmans,  Albert F. G. Leentjens,  Werner H. Mess,  Wim E. J. Weber, 
  • First Published: 10 January 2016
Research Article
Open Access

Exposure to Early Life Stress Results in Epigenetic Changes in Neurotrophic Factor Gene Expression in a Parkinsonian Rat Model

Thabisile Mpofana,  Willie M. U. Daniels,  Musa V. Mabandla, 
  • First Published: 03 January 2016