• Issue

    Pediatric Blood & Cancer: Volume 59, Issue 3

    415-596
    September 2012
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Highlights

“Good Enough” medicine: noninferiority clinical trials and the management of fever and neutropenia

Craig A. Mullen MD, PhD, 
  • Pages: 415-416
  • First Published: 15 March 2012

Reviews

Clofarabine in pediatric acute leukemia: Current findings and issues

Nobuko Hijiya MD,  Elly Barry MD,  Robert J. Arceci MD, PhD, 
  • Pages: 417-422
  • First Published: 21 February 2012

Research Articles

Free Access

First-day step-down to oral outpatient treatment versus continued standard treatment in children with cancer and low-risk fever in neutropenia. A randomized controlled trial within the multicenter SPOG 2003 FN study†

Eva Brack MD,  Nicole Bodmer MD,  Arne Simon MD,  Kurt Leibundgut MD,  Thomas Kühne MD,  Felix K. Niggli MD,  Roland A. Ammann MD, 
  • Pages: 423-430
  • First Published: 23 January 2012
Free Access

Identification of educational and infrastructural barriers to prompt antibiotic delivery in febrile neutropenia: A quality improvement initiative†‡

Erica Burry Bsc,  Angela Punnett MD,  Ashley Mehta Bsc, CCRP,  Jennifer Thull-Freedman MD, Msc,  Lisa Robinson BscN, RN,  Sumit Gupta MD, 
  • Pages: 431-435
  • First Published: 06 December 2011

Comparison of allergic reactions to pegasparaginase given intravenously versus intramuscularly†

Mahati Pidaparti,  Bruce Bostrom MD, 
  • Pages: 436-439
  • First Published: 20 October 2011

ALK+ anaplastic large cell lymphoma exhibits phosphatidylinositol-3 kinase/akt activity with retained but inactivated PTEN—A report from the Children's Oncology Group†

Charu Thakral MD,  Robert E. Hutchison MD,  Antony Shrimpton PhD,  Donna Barrett,  Joseph Laver MD,  Michael Link MD,  Devin R. Halleran BA,  Sandra Hudson PhD, 
  • Pages: 440-447
  • First Published: 05 April 2012

Experience with high dose methotrexate therapy in childhood acute lymphoblastic leukemia in a tertiary care cancer centre of a developing country†

Gauri Kapoor MD, PhD,  Rupal Sinha Msc,  Sarfraz Abedin MD, 
  • Pages: 448-453
  • First Published: 23 January 2012

Prognosis and outcome of relapsed acute lymphoblastic leukemia: A Hong Kong pediatric hematology and Oncology Study Group report†

Alex Wing Kwan Leung FHKAM (Pediatrics),  Lee Vincent FHKAM (Pediatrics),  Alan Kwok Shing Chiang PhD (HK),  Anselm Chi Wai Lee FHKAM (Pediatrics),  Frankie Wai Tsoi Cheng MD,  Daniel Ka Leung Cheuk FHKAM (Pediatrics),  Chung Wing Luk FHKAM (Pediatrics),  Siu Cheung Ling FHKAM (Pediatrics),  Chi Kong Li MD, 
  • Pages: 454-460
  • First Published: 18 May 2012

Genetic evaluation of childhood acute lymphoblastic leukemia in Iraq using FTA cards†

Lika'a Fasih Y. Al-Kzayer MD,  Kazuo Sakashita MD, PhD,  Kazuyuki Matsuda PhD,  Salma Abbas Al-Hadad MD,  Mazin Faisal Al-Jadiry MD,  Wisam Majeed Abed MD,  Jaafar M.H. Abdulkadhim MD,  Tariq Abadi Al-Shujairi MD,  Janan Ghalib Hasan MD,  Hussam M. Salih Al-Abdullah MD,  Mouroge H. Al-Ani MD,  Paiman Ali I. Saber MD,  Toshi Inoshita MD,  Minoru Kamata MD,  Kenichi Koike MD, PhD, 
  • Pages: 461-467
  • First Published: 11 January 2012

Absolute lymphocyte counts refine minimal residual disease-based risk stratification in childhood acute lymphoblastic leukemia† ‡

Karen R. Rabin MD, PhD,  M. Monica Gramatges MD,  Michael J. Borowitz MD, PhD,  Shana L. Palla MS,  Xiaodong Shi MD,  Judith F. Margolin MD,  Patrick A. Zweidler-McKay MD, PhD, 
  • Pages: 468-474
  • First Published: 18 November 2011

SUV-measurements and patient-specific corrections in pediatric Hodgkin-lymphoma: Is there a benefit for PPV in early response assessment by FDG-PET?†

Christian Furth MD,  Robert M. Meseck CM,  Ingo G. Steffen MD,  Stefan Schoenberger MD,  Timm Denecke MD,  Günter Henze MD,  Hubertus Hautzel MD,  Frank Hofheinz PhD,  Oliver Großer MA,  Patrick Hundsdoerfer MD,  Holger Amthauer MD,  Juri Ruf MD, 
  • Pages: 475-480
  • First Published: 20 December 2011

Imatinib has adverse effect on growth in children with chronic myeloid leukemia†‡

Deepak Bansal MD, DNB,  Upender Shava MD,  Neelam Varma MD,  Amita Trehan MD,  R.K. Marwaha MD, MNAMS, FIAP, FRCPCH, 
  • Pages: 481-484
  • First Published: 02 November 2011

18F-FDG microPET imaging detects early transient response to an IGF1R inhibitor in genetically engineered rhabdomyosarcoma models†

Anuradha Soundararajan PhD,  Jinu Abraham PhD,  Laura D. Nelon BS,  Suresh I. Prajapati Msc,  Lee Ann Zarzabal MS,  Joel E. Michalek PhD,  Stanton F. McHardy PhD,  Douglas S. Hawkins,  Suman Malempati MD,  Charles Keller MD, 
  • Pages: 485-492
  • First Published: 11 January 2012

Tumor necrosis predicts survival following neo-adjuvant chemotherapy for hepatoblastoma†‡

Rajkumar Venkatramani MD, MS,  Larry Wang MD, PhD,  Jemily Malvar MS,  Dennis Dias MD,  Richard Sposto PhD,  Marcio H. Malogolowkin MD,  Leo Mascarenhas MD, MS, 
  • Pages: 493-498
  • First Published: 20 December 2011

Methylation of the RASSF1A promoter is predictive of poor outcome among patients with Wilms tumor†

Junjiro Ohshima MD,  Masayuki Haruta PhD,  Yuiko Fujiwara Msc,  Naoki Watanabe MD,  Yasuhito Arai PhD,  Tadashi Ariga MD,  Hajime Okita MD,  Tsugumichi Koshinaga MD,  Takaharu Oue MD,  Shiro Hinotsu MD,  Hisaya Nakadate MD,  Hiroshi Horie MD,  Masahiro Fukuzawa MD,  Yasuhiko Kaneko MD, 
  • Pages: 499-505
  • First Published: 27 March 2012

Tumor histology during induction therapy in patients with high-risk neuroblastoma†

Rani E. George MD, PhD, MRCP,  Antonio R. Perez-Atayde MD,  Xiaopan Yao,  Wendy B. London PhD,  Robert C. Shamberger MD,  Donna Neuberg DSc,  Lisa Diller MD, 
  • Pages: 506-510
  • First Published: 11 December 2011

Antiangiogenic metronomic therapy for children with recurrent embryonal brain tumors†

Andreas Peyrl MD,  Monika Chocholous MD,  Mark W. Kieran MD, PhD,  Amedeo A. Azizi MD,  Christina Prucker MD,  Thomas Czech MD,  Karin Dieckmann MD,  Maria-Theresa Schmook MD,  Christine Haberler MD,  Ulrike Leiss PhD,  Irene Slavc MD, 
  • Pages: 511-517
  • First Published: 06 December 2011

Testing of the Akt/PKB inhibitor MK-2206 by the pediatric preclinical testing program†

Richard Gorlick MD,  John M. Maris MD,  Peter J. Houghton PhD,  Richard Lock PhD,  Hernan Carol PhD,  Raushan T. Kurmasheva PhD,  E. Anders Kolb MD,  Stephen T. Keir PhD,  C. Patrick Reynolds MD, PhD,  Min H. Kang PharmD,  Catherine A. Billups MS,  Malcolm A. Smith MD, PhD, 
  • Pages: 518-524
  • First Published: 18 November 2011

Paroxysmal nocturnal hemoglobinuria in pediatric patients†

Kevin J. Curran MD,  Nancy A. Kernan MD,  Susan E. Prockop MD,  Andromachi Scaradavou MD,  Trudy N. Small MD,  Rachel Kobos MD,  Hugo Castro-Malaspina MD,  David Araten MD,  Donna DiMichele MD,  Richard J. O'Reilly MD,  Farid Boulad MD, 
  • Pages: 525-529
  • First Published: 06 December 2011

Mutations profile of polycythemia vera and essential thrombocythemia among Japanese children†

Olfat Ismael MD,  Akira Shimada MD, PhD,  Asahito Hama MD, PhD,  Hiroshi Sakaguchi MD,  Sayoko Doisaki MD,  Hideki Muramatsu MD, PhD,  Nao Yoshida MD, PhD,  Masafumi Ito MD, PhD,  Yoshiyuki Takahashi MD, PhD,  Naohiro Akita MD, PhD,  Shosuke Sunami MD, PhD,  Yoshitoshi Ohtsuka MD, PhD,  Youji Asada MD, PhD,  Hiroyuki Fujisaki MD, PhD,  Seiji Kojima MD, PhD, 
  • Pages: 530-535
  • First Published: 21 November 2011

Implementation of multi-site neurocognitive assessments within a pediatric cooperative group: Can it be done?†

Leanne Embry PhD,  Robert D. Annett PhD,  Alicia Kunin-Batson PhD,  Sunita K. Patel PhD,  Stephen Sands PsyD,  Gregory Reaman MD,  Robert B. Noll PhD, 
  • Pages: 536-539
  • First Published: 03 May 2012

Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: A pilot study†

Sharon M. Castellino MD, MSc,  Janet A. Tooze PhD, MPH,  Lynn Flowers PhD,  Debbie F. Hill MA,  Kevin P. McMullen MD,  Edward G. Shaw MD,  Susan K. Parsons MD, MRP, 
  • Pages: 540-547
  • First Published: 11 January 2012

Ventricular systolic reserve in asymptomatic children previously treated with low doses of anthracyclines: A longitudinal, prospective exercise echocardiography study†

Fabio V. Guimaraes-Filho MD, PhD,  Doralice M. Tan MD,  Joao C. F. Braga MD, PhD,  Alexandre Rodrigues MD, PhD,  Paulo H. Waib MD, PhD,  Beatriz B. Matsubara MD, PhD, 
  • Pages: 548-552
  • First Published: 11 December 2011

The management of menstrual suppression and uterine bleeding: A survey of current practices in the pediatric blood and marrow transplant consortium†

Enitan A. Adegite MBBS, MPH,  Rakesh K. Goyal MD,  Pamela J. Murray MD, MHP,  Mike Marshal PhD,  Gina S. Sucato MD, MPH, 
  • Pages: 553-557
  • First Published: 13 February 2012

Brief Reports

DICER1 Mutations in embryonal rhabdomyosarcomas from children with and without familial PPB-tumor predisposition syndrome†

Leslie Doros MD,  Jiandong Yang PhD,  Louis Dehner MD,  Christopher T. Rossi MD,  Kerry Skiver BS,  Jason A. Jarzembowski MD, PhD,  Yoav Messinger MD,  Kris Ann Schultz MD,  Gretchen Williams,  Nicolas André MD, PhD,  D. Ashley Hill MD, 
  • Pages: 558-560
  • First Published: 16 December 2011

Research Articles

Isochromosome 17q, MYC amplification and large cell/anaplastic phenotype in a case of medullomyoblastoma with extracranial metastases†

Karen D. Wright MD,  Kendra von der Embse BS,  Jamie Coleman MD,  Zoltan Patay MD, PhD,  David W. Ellison MD, PhD,  Amar Gajjar MD, 
  • Pages: 561-564
  • First Published: 06 December 2011

Brief Reports

KCNQ1OT1 hypomethylation: A Novel disguised genetic predisposition in sporadic pediatric adrenocortical tumors?†‡

Mark Wijnen,  Mariëlle Alders MD, PhD,  Christian M. Zwaan MD, PhD,  Anja Wagner MD, PhD,  Marry M. van den Heuvel-Eibrink MD, PhD, 
  • Pages: 565-566
  • First Published: 11 December 2011

VEGF expression in residual tumor cells in orbital retinoblastoma (IRSS stage III) treated with NACT: A prospective study†

Venkatraman Radhakrishnan MD,  Seema Kashyap MD,  Lata Singh MSc,  Sameer Bakhshi MD, 
  • Pages: 567-569
  • First Published: 15 November 2011

Radiation recall myositis in pediatric Ewing sarcoma†

Jona Hattangadi MD,  Brittany Esty MD,  Brian Winey PhD,  Shauna Duigenan MD,  Mary Huang MD,  Torunn Yock MD, MPH, 
  • Pages: 570-572
  • First Published: 20 October 2011

Clonal cytogenetic abnormalities after tyrosine kinase inhibitor therapy in Ph+ all resolution after decitabine therapy†

Sharon Lockhart MD,  Lisa McDonald RN,  Michael Rytting MD,  Ka Wah Chan MD, 
  • Pages: 573-575
  • First Published: 09 September 2011
Open Access

In vitro sensitivity to dasatinib in lymphoblasts from a patient with t(17;19)(q22;p13) gene rearrangement pre-B acute lymphoblastic leukemia†

Jason M. Glover MD,  Marc Loriaux MD, PhD,  Jeffrey W. Tyner PhD,  Brian J. Druker MD,  Bill H. Chang MD, PhD, 
  • Pages: 576-579
  • First Published: 28 October 2011

The strange case of the lost NRAS mutation in a child with juvenile myelomonocytic leukemia†

Paola De Filippi PhD,  Marco Zecca MD,  Francesca Novara PhD,  Daniela Lisini PhD,  Emanuela Maserati PhD,  Francesco Pasquali MD, PhD,  Vittorio Rosti MD,  Carmelo Carlo-Stella MD,  Niki Zavras MD,  Claudia Cagioni PhD,  Orsetta Zuffardi PhD,  Daria Pagliara MD,  Cesare Danesino MD, PhD,  Franco Locatelli MD, PhD, 
  • Pages: 580-582
  • First Published: 19 December 2011

Long-term graft-versus-tumor effect following reduced intensity hematopoietic stem cell transplantation in a child with metastatic renal cell carcinoma†

Hee Jo Baek MD,  Dong Kyun Han MD,  Tai Ju Hwang MD,  Sul Hee Bae MD,  Yoo Duk Choi MD,  Hoon Kook MD, 
  • Pages: 583-585
  • First Published: 09 January 2012

Initial testing of the multitargeted kinase inhibitor pazopanib by the pediatric preclinical testing program†

Stephen T. Keir PhD,  Christopher L. Morton BS,  Jianrong Wu PhD,  Raushan T. Kurmasheva PhD,  Peter J. Houghton PhD,  Malcolm A. Smith MD, PhD, 
  • Pages: 586-588
  • First Published: 20 December 2011

Letters to the Editor

13-cis-retinoic acid-associated bone marrow edema in neuroblastoma

Yuya Sato,  Shigeko Kuwashima,  Hidemitsu Kurosawa,  Kenichi Sugita,  Keitaro Fukushima,  Osamu Arisaka, 
  • Pages: 589-590
  • First Published: 21 February 2012

Favorable outcome with conservative treatment for children with low grade brainstem tumors

Andrew W. Walter MS, MD,  George I. Jallo MD, 
  • Page: 591
  • First Published: 19 March 2012

Bleeding Disorders and Noonan Syndrome

Anjali A. Sharathkumar MD, MS, 
  • Page: 592
  • First Published: 07 May 2012

Bleeding disorders in Noonan Syndrome

Benjamin Briggs MD,  Joseph D. Dickerman MD, 
  • Page: 593
  • First Published: 05 April 2012

Meeting Report

Meeting report—neuroblastoma research symposium, London, October 14, 2011†

Jane Carr-Wilkinson,  Luke Wylie,  John Anderson,  Juliet Gray, 
  • Pages: 594-596
  • First Published: 07 June 2012