• Issue

    Arthritis & Rheumatism: Volume 64, Issue 3

    599-942
    March 2012
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In This Issue

In this issue

  • First Published: 28 February 2012

Special Articles

ACR Presidential Address: Advancing rheumatology: Mission possible†

David G. Borenstein, 
  • Pages: 599-603
  • First Published: 12 December 2011

Editorial: Hepatitis C virus–related cryoglobulinemic vasculitis: Emerging trends in therapy

E. William St.Clair, 
  • Pages: 604-608
  • First Published: 06 December 2011

Editorial: Systemic autoimmunity caused by Fas deficiency in macrophages: A new perspective on the first identified autoimmunity gene

John D. Mountz,  Jun Li,  Hui-Chen Hsu, 
  • Pages: 609-612
  • First Published: 02 December 2011

Editorial: Osteoarthritis as an autoinflammatory disease caused by chondrocyte-mediated inflammatory responses

Y. T. Konttinen,  T. Sillat,  G. Barreto,  M. Ainola,  D. C. E. Nordström, 
  • Pages: 613-616
  • First Published: 30 November 2011

Rheumatoid Arthritis

Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs†‡

Roy Fleischmann,  Maurizio Cutolo,  Mark C. Genovese,  Eun Bong Lee,  Keith S. Kanik,  Seth Sadis,  Carol A. Connell,  David Gruben,  Sriram Krishnaswami,  Gene Wallenstein,  Bethanie E. Wilkinson,  Samuel H. Zwillich, 
  • Pages: 617-629
  • First Published: 27 September 2011

Prescribing practices in a US cohort of rheumatoid arthritis patients before and after publication of the American College of Rheumatology treatment recommendations

Leslie R. Harrold,  J. Timothy Harrington,  Jeffrey R. Curtis,  Daniel E. Furst,  Mary Jane Bentley,  Ying Shan,  George Reed,  Joel Kremer,  Jeffrey D. Greenberg, 
  • Pages: 630-638
  • First Published: 27 September 2011

Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: Balance between diabetogenic effects and inflammation reduction†

Debby den Uyl,  Daniel H. van Raalte,  Michael T. Nurmohamed,  Willem F. Lems,  Johannes W. J. Bijlsma,  Jos N. Hoes,  Ben A. C. Dijkmans,  Michaela Diamant, 
  • Pages: 639-646
  • First Published: 27 September 2011

NLRP1 gene polymorphism influences gene transcription and is a risk factor for rheumatoid arthritis in Han Chinese

Jiangdong Sui,  Hua Li,  Yongfei Fang,  Yang Liu,  Minhui Li,  Bing Zhong,  Fei Yang,  Qiang Zou,  Yuzhang Wu, 
  • Pages: 647-654
  • First Published: 04 October 2011

Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans

Ted R. Mikuls,  Tricia LeVan,  Karen A. Gould,  Fang Yu,  Geoffrey M. Thiele,  Kimberly K. Bynote,  Doyt Conn,  Beth L. Jonas,  Leigh F. Callahan,  Edwin Smith,  Richard Brasington,  Larry W. Moreland,  Richard Reynolds,  Angelo Gaffo,  S. Louis Bridges Jr., 
  • Pages: 655-664
  • First Published: 11 October 2011
Open Access

Replication of association of the PTPRC gene with response to anti–tumor necrosis factor therapy in a large UK cohort†

Darren Plant,  Rita Prajapati,  Kimme L. Hyrich,  Ann W. Morgan,  Anthony G. Wilson,  John D. Isaacs,  Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate ,  Anne Barton, 
  • Pages: 665-670
  • First Published: 27 September 2011

The CD14brightCD16+ monocyte subset is expanded in rheumatoid arthritis and promotes expansion of the Th17 cell population

Manuela Rossol,  Stephan Kraus,  Matthias Pierer,  Christoph Baerwald,  Ulf Wagner, 
  • Pages: 671-677
  • First Published: 17 October 2011

Experimental Arthritis

Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6–deficient mice

Deepa Hammaker,  Katharyn Topolewski,  Meghan Edgar,  Toshio Yoshizawa,  Akihisa Fukushima,  David L. Boyle,  Esther Cory Burak,  Robert L. Sah,  Gary S. Firestein, 
  • Pages: 678-687
  • First Published: 27 September 2011

Osteoarthritis

Prediction of progression of radiographic knee osteoarthritis using tibial trabecular bone texture

T. Woloszynski,  P. Podsiadlo,  G. W. Stachowiak,  M. Kurzynski,  L. S. Lohmander,  M. Englund, 
  • Pages: 688-695
  • First Published: 11 October 2011

Anterior cruciate ligament changes in the human knee joint in aging and osteoarthritis

Akihiko Hasegawa,  Shuhei Otsuki,  Chantal Pauli,  Shigeru Miyaki,  Shantanu Patil,  Nikolai Steklov,  Mitsuo Kinoshita,  James Koziol,  Darryl D. D'Lima,  Martin K. Lotz, 
  • Pages: 696-704
  • First Published: 17 October 2011

Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice

Richard F. Loeser,  Amy L. Olex,  Margaret A. McNulty,  Cathy S. Carlson,  Michael F. Callahan,  Cristin M. Ferguson,  Jeff Chou,  Xiaoyan Leng,  Jacquelyn S. Fetrow, 
  • Pages: 705-717
  • First Published: 03 October 2011

Chondrocyte Biology

75-kd sirtuin 1 blocks tumor necrosis factor α–mediated apoptosis in human osteoarthritic chondrocytes

Hanna Oppenheimer,  Odile Gabay,  Hadar Meir,  Amir Haze,  Leonid Kandel,  Meir Liebergall,  Viktoria Gagarina,  Eun Jin Lee,  Mona Dvir-Ginzberg, 
  • Pages: 718-728
  • First Published: 10 October 2011

Substance P and norepinephrine modulate murine chondrocyte proliferation and apoptosis

Alfred Opolka,  Rainer H. Straub,  Anja Pasoldt,  Joachim Grifka,  Susanne Grässel, 
  • Pages: 729-739
  • First Published: 31 October 2011

Bone Biology

Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis

Seung-Ki Kwok,  Mi-La Cho,  Mi-Kyung Park,  Hye-Joa Oh,  Jin-Sil Park,  Yang-Mi Her,  Seon-Yeong Lee,  Jeehee Youn,  Ji Hyeon Ju,  Kyung Su Park,  Sung-Il Kim,  Ho-Youn Kim,  Sung-Hwan Park, 
  • Pages: 740-751
  • First Published: 03 October 2011

T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice

Karen M. Doody,  Stéphanie Bussières-Marmen,  Ailian Li,  Marilène Paquet,  Janet E. Henderson,  Michel L. Tremblay, 
  • Pages: 752-761
  • First Published: 03 October 2011

Spondylarthritis

Interferon-γ regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis

Jelena M. Kezic,  Michael P. Davey,  Tibor T. Glant,  James T. Rosenbaum,  Holly L. Rosenzweig, 
  • Pages: 762-771
  • First Published: 10 October 2011

Enhanced phosphorylation of STAT-1 is dependent on double-stranded RNA–dependent protein kinase signaling in HLA–B27–expressing U937 monocytic cells

Marja Ruuska,  Anna S. Sahlberg,  Robert A. Colbert,  Kaisa Granfors,  Markus A. Penttinen, 
  • Pages: 772-777
  • First Published: 03 October 2011

Systemic Lupus Erythematosus

Autoantibodies to estrogen receptor α interfere with T lymphocyte homeostasis and are associated with disease activity in systemic lupus erythematosus

Tania Colasanti,  Angela Maselli,  Fabrizio Conti,  Massimo Sanchez,  Cristiano Alessandri,  Cristiana Barbati,  Davide Vacirca,  Antonella Tinari,  Flavia Chiarotti,  Antonello Giovannetti,  Flavia Franconi,  Guido Valesini,  Walter Malorni,  Marina Pierdominici,  Elena Ortona, 
  • Pages: 778-787
  • First Published: 03 October 2011

Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons

Rivka C. Stone,  Di Feng,  Jing Deng,  Sukhwinder Singh,  Lisong Yang,  Patricia Fitzgerald-Bocarsly,  Maija-Leena Eloranta,  Lars Rönnblom,  Betsy J. Barnes, 
  • Pages: 788-798
  • First Published: 03 October 2011

CREMα suppresses spleen tyrosine kinase expression in normal but not systemic lupus erythematosus T cells

Debjani Ghosh,  Katalin Kis-Toth,  Yuang-Taung Juang,  George C. Tsokos, 
  • Pages: 799-807
  • First Published: 27 September 2011

Requirement of myeloid cell–specific Fas expression for prevention of systemic autoimmunity in mice

Carla M. Cuda,  Hemant Agrawal,  Alexander V. Misharin,  G. Kenneth Haines III,  Jack Hutcheson,  Evan Weber,  Joseph A. Schoenfeldt,  Chandra Mohan,  Richard M. Pope,  Harris Perlman, 
  • Pages: 808-820
  • First Published: 05 December 2011

Systemic Sclerosis

Timing of transition between capillaroscopic patterns in systemic sclerosis

Alberto Sulli,  Carmen Pizzorni,  Vanessa Smith,  Giuseppe Zampogna,  Francesca Ravera,  Maurizio Cutolo, 
  • Pages: 821-825
  • First Published: 29 November 2011

The autoantigen DNA topoisomerase I interacts with chemokine receptor 7 and exerts cytokine-like effects on dermal fibroblasts

Julie Arcand,  Geneviève Robitaille,  Martial Koenig,  Jean-Luc Senécal,  Yves Raymond, 
  • Pages: 826-834
  • First Published: 27 September 2011

Vasculitis

A randomized controlled trial of rituximab following failure of antiviral therapy for hepatitis C virus–associated cryoglobulinemic vasculitis†

Michael C. Sneller,  Zonghui Hu,  Carol A. Langford, 
  • Pages: 835-842
  • First Published: 06 December 2011

A randomized controlled trial of rituximab for the treatment of severe cryoglobulinemic vasculitis†

S. De Vita,  L. Quartuccio,  M. Isola,  C. Mazzaro,  P. Scaini,  M. Lenzi,  M. Campanini,  C. Naclerio,  A. Tavoni,  M. Pietrogrande,  C. Ferri,  M. T. Mascia,  P. Masolini,  A. Zabotti,  M. Maset,  D. Roccatello,  A. L. Zignego,  P. Pioltelli,  A. Gabrielli,  D. Filippini,  O. Perrella,  S. Migliaresi,  M. Galli,  S. Bombardieri,  G. Monti, 
  • Pages: 843-853
  • First Published: 06 December 2011

Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: Relevance for recent optic nerve ischemia

Mattia Baldini,  Norma Maugeri,  Giuseppe A. Ramirez,  Chiara Giacomassi,  Alessandra Castiglioni,  Sergio Prieto-González,  Marc Corbera-Bellalta,  Gabriele Di Comite,  Ilenia Papa,  Giacomo Dell'Antonio,  Enrico Ammirati,  Ivan Cuccovillo,  Viviana Vecchio,  Alberto Mantovani,  Patrizia Rovere-Querini,  Maria Grazia Sabbadini,  Maria C. Cid,  Angelo A. Manfredi, 
  • Pages: 854-865
  • First Published: 11 October 2011

The role of 18F-fluorodeoxyglucose–positron emission tomography in the assessment of disease activity in patients with Takayasu arteritis

Kwang-Hoon Lee,  Arthur Cho,  Yun-Jung Choi,  Sang-Won Lee,  You-Jung Ha,  Se-Jin Jung,  Min-Chan Park,  Jong-Doo Lee,  Soo-Kon Lee,  Yong-Beom Park, 
  • Pages: 866-875
  • First Published: 11 October 2011

Gout

Rilonacept (Interleukin-1 Trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: Results of a phase II randomized, double-blind, placebo-controlled trial†

H. Ralph Schumacher Jr.,  John S. Sundy,  Robert Terkeltaub,  Howard R. Knapp,  Scott J. Mellis,  Neil Stahl,  George D. Yancopoulos,  Yuhwen Soo,  Shirletta King-Davis,  Steven P. Weinstein,  Allen R. Radin,  0619 Study Group , 
  • Pages: 876-884
  • First Published: 04 January 2012

Fibromyalgia

Development of responder definitions for fibromyalgia clinical trials

Lesley M. Arnold,  David A. Williams,  James I. Hudson,  Susan A. Martin,  Daniel J. Clauw,  Leslie J. Crofford,  Fujun Wang,  Birol Emir,  Chinglin Lai,  Rong Zablocki,  Philip J. Mease, 
  • Pages: 885-894
  • First Published: 27 September 2011

Autoinflammatory Disease

Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity

Yin Liu,  Yuval Ramot,  Antonio Torrelo,  Amy S. Paller,  Nuo Si,  Sofia Babay,  Peter W. Kim,  Afzal Sheikh,  Chyi-Chia Richard Lee,  Yongqing Chen,  Angel Vera,  Xue Zhang,  Raphaela Goldbach-Mansky,  Abraham Zlotogorski, 
  • Pages: 895-907
  • First Published: 27 September 2011

Efficacy of etanercept in the tumor necrosis factor receptor–associated periodic syndrome: A prospective, open-label, dose-escalation study†

Ariel C. Bulua,  Douglas B. Mogul,  Ivona Aksentijevich,  Harjot Singh,  David Y. He,  Larry R. Muenz,  Michael M. Ward,  Cheryl H. Yarboro,  Daniel L. Kastner,  Richard M. Siegel,  Keith M. Hull, 
  • Pages: 908-913
  • First Published: 17 October 2011

IgG4-Related Disease

Involvement of activation of Toll-like receptors and nucleotide-binding oligomerization domain–like receptors in enhanced IgG4 responses in autoimmune pancreatitis

Tomohiro Watanabe,  Kouhei Yamashita,  Saori Fujikawa,  Toshiharu Sakurai,  Masatoshi Kudo,  Masahiro Shiokawa,  Yuzo Kodama,  Kazushige Uchida,  Kazuichi Okazaki,  Tsutomu Chiba, 
  • Pages: 914-924
  • First Published: 03 October 2011

Pediatric Rheumatology

Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA–DRB1 alleles encoding the shared epitope

Sampath Prahalad,  Susan D. Thompson,  Karen N. Conneely,  Yunxuan Jiang,  Traci Leong,  Jennifer Prozonic,  Milton R. Brown,  Lori A. Ponder,  Sheila T. Angeles-Han,  Larry B. Vogler,  Christine Kennedy,  Carol A. Wallace,  Carol A. Wise,  Marilynn Punaro,  Ann Reed,  Jane L. Park,  Elizabeth D. Mellins,  Andrew S. Zeft,  John F. Bohnsack,  David N. Glass, 
  • Pages: 925-930
  • First Published: 27 September 2011

Preferential transmission of genetic risk variants of candidate loci at 6p21 from asymptomatic grandparents to mothers of children with neonatal lupus

Amit Saxena,  Erin McDonnell,  Paula S. Ramos,  Satria Sajuthi,  Miranda C. Marion,  Carl D. Langefeld,  Jill P. Buyon,  Robert M. Clancy, 
  • Pages: 931-939
  • First Published: 27 September 2011

Erratum

Free Access

Erratum: Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells

H. Travis Ichikawa,  Thomas Conley,  Tony Muchamuel,  Jing Jiang,  Susan Lee,  Teresa Owen,  Jennifer Barnard,  Sarah Nevarez,  Bruce I. Goldman,  Christopher J. Kirk,  R. John Looney,  Jennifer H. Anolik, 
  • Page: 939
  • First Published: 28 February 2012

Letters

Whence the rheumatologist

David H. Neustadt MD, FACP, MACR, 
  • Page: 940
  • First Published: 11 November 2011

New evidence of the role of the hypoxia-regulated pathway in nucleus pulposus cell survival: Comment on the article by Hiyama et al

Feng-Lai Yuan MD,  Hui-Ren Wang MD,  Lu Cao MD,  Ping-Guo Duan MD,  Jian Dong PhD, 
  • Pages: 940-941
  • First Published: 17 November 2011

Reply

Makarand V. Risbud PhD,  Irving M. Shapiro PhD, 
  • Pages: 941-942
  • First Published: 17 November 2011

Clinical Image

Salmonella mycotic aneurysm in a patient receiving etanercept for rheumatoid arthritis

Amandine Quatre MD,  Anne-Laurence Demoux MD,  Jerome Soussan MD,  Yves Frances MD,  Pascal Rossi MD, PhD, 
  • Page: 942
  • First Published: 14 November 2011

ACR Announcements

ACR announcements

  • First Published: 28 February 2012