Arthritis & Rheumatism: Vol 60, No 7

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IssueVolume 77, Issue 8
Pages: 941-1043
August 2025

IssueVolume 7, Issue 8
August 2025

Arthritis & Rheumatism

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Arthritis & Rheumatism: Volume 60, Issue 7

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In This Issue

In this issue

Editorial

Fibroblast growth factor 2: A new key player in osteoarthritis

B lymphocyte cytokines and rheumatic autoimmune disease

International rheumatology networking: The 2008 american college of rheumatology/european league against rheumatism exchange program

Rheumatoid Arthritis Clinical Studies

Risk of tuberculosis is higher with anti–tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective french research axed on tolerance of biotherapies registry†

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo†‡

Correction(s) for this article

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo

Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis

Disease remission state in patients treated with the combination of tumor necrosis factor blockade and methotrexate or with disease-modifying antirheumatic drugs: A clinical and imaging comparative study

Rheumatoid Arthritis Basic Science Studies

Anti–cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis

Alterations of the synovial T cell repertoire in anti–citrullinated protein antibody–positive rheumatoid arthritis†

Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1β through the NF-κB and MAPK pathways in rheumatoid arthritis

PAN–DR-Binding Hsp60 self epitopes induce an interleukin-10–mediated immune response in rheumatoid arthritis

Spondylarthritis

Spondylarthritis in HLA–B27/human β2-microglobulin–transgenic rats is not prevented by lack of CD8

Enthesis inflammation in recurrent acute anterior uveitis without spondylarthritis

Sjögren's Syndrome

The CGGGG insertion/deletion polymorphism of the IRF5 promoter is a strong risk factor for primary Sjögren's syndrome

Experimental Arthritis

Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum–induced arthritis in vivo

Osteoarthritis

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis

Changes in proximal femoral mineral geometry precede the onset of radiographic hip osteoarthritis: The study of osteoporotic fractures

Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study

Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women

Functional analysis of the osteoarthritis susceptibility–associated GDF5 regulatory polymorphism

Orthopedics

The small ubiquitin-like modifier mediates the resistance of prosthesis-loosening fibroblast-like synoviocytes against fas-induced apoptosis

Systemic Lupus Erythematosus

Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid

Systemic activation of the immune system induces aberrant BAFF and APRIL expression in B cells in patients with systemic lupus erythematosus

Relationship between elevated cerebrospinal fluid levels of plasminogen activator inhibitor 1 and neuronal destruction in patients with neuropsychiatric systemic lupus erythematosus

Childhood Arthritis

Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis

Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets

Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis

Intravenous immunoglobulin and salicylate differentially modulate pathogenic processes leading to vascular damage in a model of Kawasaki disease

Systemic Sclerosis

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen

Vasculitis

A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody–associated vasculitis

Clinical Image

Clinical image: Cerebral amyloid angiopathy

Fibromyalgia

Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains

Lyme Arthritis

Analysis of Borrelia burgdorferi genotypes in patients with lyme arthritis: High frequency of ribosomal RNA intergenic spacer type 1 strains in antibiotic-refractory arthritis

Myositis

Characterization and peripheral blood biomarker assessment of anti–Jo-1 antibody–positive interstitial lung disease

RNA helicase encoded by melanoma differentiation–associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease†

Gout

Severe gouty arthritis and mild neurologic symptoms due to F199C, a newly identified variant of the hypoxanthine guanine phosphoribosyltransferase

Reply

Reply to letter by Nardelli and Schell commenting on the pathogenesis of lyme arthritis

Letter

Mortality in rheumatoid arthritis patients with heart failure: Comment on the article by Davis et al

Reply

Reply

Letter

Challenges in mapping non–HLA–DRB1 major histocompatibility genes in rheumatoid arthritis: Comment on the article by Vignal et al

Reply

Reply

Letter

The clinical relevance of a prediction rule for disease outcome in patients with undifferentiated arthritis: Comment on the article by van der Helm-van Mil et al

Reply

Reply

Erratum

Risk of tuberculosis is higher with anti–tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective french research axed on tolerance of biotherapies registry ^†

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo ^†^‡

Alterations of the synovial T cell repertoire in anti–citrullinated protein antibody–positive rheumatoid arthritis ^†

Spondylarthritis in HLA–B27/human β₂-microglobulin–transgenic rats is not prevented by lack of CD8

RNA helicase encoded by melanoma differentiation–associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease ^†