• Issue

    Hepatology: Volume 56, Issue 4

    1191-1590
    October 2012
Previous Issue|Next Issue
Export Citation(s)Download PDF(s)

Introducing The AASLD President

Free Access

Introducing the AASLD president: Guadalupe Garcia-Tsao†

Roberto J. Groszmann M.D., FRCP, 
  • Pages: 1191-1193
  • First Published: 07 September 2012

Editorials

Free Access

Pathogenesis of cholestatic itch: Old questions, new answers, and future opportunities†‡

David E.J. Jones M.D., Ph.D., FRCP, 
  • Pages: 1194-1196
  • First Published: 18 May 2012
Free Access

Natural killer cells and hepatitis C: Natural killer p46 expression linked to antiviral and antifibrotic activity†

Maximilian Heeg,  Robert Thimme M.D., 
  • Pages: 1197-1200
  • First Published: 21 May 2012

Viral Hepatitis

Free Access

Natural killer p46High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis†‡

Benjamin Krämer,  Christian Körner,  Moritz Kebschull,  Andreas Glässner,  Marianne Eisenhardt,  Hans-Dieter Nischalke,  Michael Alexander,  Tilman Sauerbruch,  Ulrich Spengler,  Jacob Nattermann, 
  • Pages: 1201-1213
  • First Published: 24 April 2012
Free Access

Race- and gender-related variation in natural killer p46 expression associated with differential anti-hepatitis c virus immunity†‡

Lucy Golden-Mason,  Amy E.L. Stone,  Kiran M. Bambha,  Linling Cheng,  Hugo R. Rosen, 
  • Pages: 1214-1222
  • First Published: 13 April 2012
Free Access

The impact of lifetime alcohol use on hepatitis C treatment outcomes in privately insured members of an integrated health care plan†

Marcia Russell,  Mary Patricia Pauly,  Charles Denton Moore,  Constance Chia,  Jennifer Dorrell,  Renee J. Cunanan,  Gayle Witt,  Scott Martin, 
  • Pages: 1223-1230
  • First Published: 05 April 2012
Free Access

25-hydroxyvitamin D3 suppresses hepatitis C virus production†‡

Takuya Matsumura,  Takanobu Kato,  Nao Sugiyama,  Megumi Tasaka-Fujita,  Asako Murayama,  Takahiro Masaki,  Takaji Wakita,  Michio Imawari, 
  • Pages: 1231-1239
  • First Published: 06 April 2012
Free Access

Subset of Suz12/PRC2 target genes is activated during hepatitis B virus replication and liver carcinogenesis associated with HBV X protein†

Leo L. Studach,  Stephan Menne,  Stefano Cairo,  Marie Annick Buendia,  Ronald L. Hullinger,  Lydie Lefrançois,  Philippe Merle,  Ourania M. Andrisani, 
  • Pages: 1240-1251
  • First Published: 13 April 2012
Free Access

Comparison of hepatitis C virus treatment between incarcerated and community patients†‡

John P. Rice,  David Burnett,  Helena Tsotsis,  Mary J. Lindstrom,  Daniel D. Cornett,  Patricia Voermans,  Jill Sawyer,  Rob Striker,  Michael R. Lucey, 
  • Pages: 1252-1260
  • First Published: 13 April 2012
Free Access

Hepatic steatosis and steatohepatitis in human immunodeficiency virus/hepatitis C virus–coinfected patients†

Juan Macías,  Juan Berenguer,  Miguel A. Japón,  José A. Girón-González,  Antonio Rivero,  Luis F. López-Cortés,  Ana Moreno,  Manuel Márquez,  José A. Iribarren,  Enrique Ortega,  Pilar Miralles,  Nicolás Merchante,  Juan A. Pineda, 
  • Pages: 1261-1270
  • First Published: 16 April 2012
Free Access

Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in nonalcoholic fatty liver diseases†

Hironori Ochi,  Masashi Hirooka,  Yohei Koizumi,  Teruki Miyake,  Yoshio Tokumoto,  Yoshiko Soga,  Fujimasa Tada,  Masanori Abe,  Yoichi Hiasa,  Morikazu Onji, 
  • Pages: 1271-1278
  • First Published: 05 April 2012

Steatohepatitis/Metabolic Liver Disease

Free Access

Liver-specific ablation of Krüppel-associated box–associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma†

Karolina Bojkowska,  Fabio Aloisio,  Marco Cassano,  Adamandia Kapopoulou,  Francesca Santoni de Sio,  Nadine Zangger,  Sandra Offner,  Cristina Cartoni,  Charles Thomas,  Simon Quenneville,  Kai Johnsson,  Didier Trono, 
  • Pages: 1279-1290
  • First Published: 08 June 2012
Free Access

Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism†‡

Claudia O. Zein,  Rocio Lopez,  Xiaoming Fu,  John P. Kirwan,  Lisa M. Yerian,  Arthur J. McCullough,  Stanley L. Hazen,  Ariel E. Feldstein, 
  • Pages: 1291-1299
  • First Published: 13 April 2012
Free Access

Specific bile acids inhibit hepatic fatty acid uptake in mice†

Biao Nie,  Hyo Min Park,  Melissa Kazantzis,  Min Lin,  Amy Henkin,  Stephanie Ng,  Sujin Song,  Yuli Chen,  Heather Tran,  Robin Lai,  Chris Her,  Jacquelyn J. Maher,  Barry M. Forman,  Andreas Stahl, 
  • Pages: 1300-1310
  • First Published: 24 April 2012
Free Access

Relationship between adipose tissue insulin resistance and liver histology in nonalcoholic steatohepatitis: A pioglitazone versus vitamin E versus placebo for the treatment of nondiabetic patients with nonalcoholic steatohepatitis trial follow-up study†

Lauren N. Bell,  Jiangxia Wang,  Sriya Muralidharan,  Sadhana Chalasani,  Allison M. Fullenkamp,  Laura A. Wilson,  Arun J. Sanyal,  Kris V. Kowdley,  Brent A. Neuschwander-Tetri,  Elizabeth M. Brunt,  Arthur J. McCullough,  Nathan M. Bass,  Anna Mae Diehl,  Aynur Unalp-Arida,  Naga Chalasani,  for the Nonalcoholic Steatohepatitis Clinical Research Network , 
  • Pages: 1311-1318
  • First Published: 24 April 2012
Free Access

Retinoids ameliorate insulin resistance in a leptin-dependent manner in mice†

Hiroyuki Tsuchiya,  Yoshito Ikeda,  Yu Ebata,  Chihiro Kojima,  Rikutaro Katsuma,  Tatsuaki Tsuruyama,  Tomohiko Sakabe,  Kohei Shomori,  Noriko Komeda,  Shoko Oshiro,  Hideharu Okamoto,  Kazuko Takubo,  Susumu Hama,  Koichi Shudo,  Kentaro Kogure,  Goshi Shiota, 
  • Pages: 1319-1330
  • First Published: 24 April 2012

Hepatobiliary Malignancies

Free Access

Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells†

Edward Kai-Hua Chow,  Ling-ling Fan,  Xin Chen,  J. Michael Bishop, 
  • Pages: 1331-1341
  • First Published: 13 April 2012
Free Access

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma†

Hang Li,  Ke Wu,  Kaixiong Tao,  Libo Chen,  Qichang Zheng,  Xiaoming Lu,  Jun Liu,  Liang Shi,  Chuanqiao Liu,  Guobin Wang,  Weiping Zou, 
  • Pages: 1342-1351
  • First Published: 13 April 2012
Free Access

Intraductal papillary neoplasm of the bile duct: A biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas?†

Flavio G. Rocha,  Hwajeong Lee,  Nora Katabi,  Ronald P. DeMatteo,  Yuman Fong,  Michael I. D'Angelica,  Peter J. Allen,  David S. Klimstra,  William R. Jarnagin, 
  • Pages: 1352-1360
  • First Published: 13 April 2012
Free Access

Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing†

Diana Vetter,  Michal Cohen-Naftaly,  Augusto Villanueva,  Youngmin A. Lee,  Peri Kocabayoglu,  Rebekka Hannivoort,  Goutham Narla,  Josep M. Llovet,  Swan N. Thung,  Scott L. Friedman, 
  • Pages: 1361-1370
  • First Published: 26 April 2012
Free Access

Alpha-fetoprotein has no prognostic role in small hepatocellular carcinoma identified during surveillance in compensated cirrhosis†

Edoardo G. Giannini,  Simona Marenco,  Giacomo Borgonovo,  Vincenzo Savarino,  Fabio Farinati,  Paolo Del Poggio,  Gian Ludovico Rapaccini,  Maria Anna Di Nolfo,  Luisa Benvegnù,  Marco Zoli,  Franco Borzio,  Eugenio Caturelli,  Maria Chiaramonte,  Franco Trevisani,  for the Italian Liver Cancer (ITA.LI.CA) group , 
  • Pages: 1371-1379
  • First Published: 26 April 2012
Free Access

Oncogenic activation of glypican-3 by c-Myc in human hepatocellular carcinoma†

Li Li,  Ronghua Jin,  Xiaoli Zhang,  Fudong Lv,  Lifeng Liu,  Daojie Liu,  Kai Liu,  Ning Li,  Dexi Chen, 
  • Pages: 1380-1390
  • First Published: 18 June 2012

Autoimmune, Cholestatic and Biliary Disease

Free Access

Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions†‡

Andreas E. Kremer,  Remco van Dijk,  Pamela Leckie,  Frank G. Schaap,  Edith M.M. Kuiper,  Thomas Mettang,  Katrin S. Reiners,  Ulrike Raap,  Henk R. van Buuren,  Karel J. van Erpecum,  Nathan A. Davies,  Christian Rust,  Andreas Engert,  Rajiv Jalan,  Ronald P.J. Oude Elferink,  Ulrich Beuers, 
  • Pages: 1391-1400
  • First Published: 02 April 2012
Free Access

Clinical significance of azathioprine metabolites for the maintenance of remission in autoimmune hepatitis†‡

Harpreet K. Dhaliwal,  Rory Anderson,  Elizabeth L. Thornhill,  Sarah Schneider,  Elaine McFarlane,  Dermot Gleeson,  Lynne Lennard, 
  • Pages: 1401-1408
  • First Published: 05 April 2012
Free Access

Primary biliary cirrhosis and cancer risk: A systematic review and meta-analysis†

Yan Liang,  Zaixing Yang,  Renqian Zhong, 
  • Pages: 1409-1417
  • First Published: 13 April 2012
Free Access

The immunobiology of colitis and cholangitis in interleukin-23p19 and interleukin-17a deleted dominant negative form of transforming growth factor beta receptor type ii mice†‡

Yugo Ando,  Guo-Xiang Yang,  Masanobu Tsuda,  Kazuhito Kawata,  Weici Zhang,  Takahiko Nakajima,  Koichi Tsuneyama,  Patrick Leung,  Zhe-Xiong Lian,  Kazuichi Okazaki,  William M. Ridgway,  Gary L. Norman,  Aftab A. Ansari,  Xiao-Song He,  Ross L. Coppel,  M. Eric Gershwin, 
  • Pages: 1418-1426
  • First Published: 24 April 2012

Liver Failure/Cirrhosis/Portal Hypertension

Free Access

Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents†

Yuko Kageyama,  Hitoshi Ikeda,  Naoko Watanabe,  Masakazu Nagamine,  Yoshika Kusumoto,  Mitsuru Yashiro,  Yumiko Satoh,  Tatsuo Shimosawa,  Koji Shinozaki,  Tomoaki Tomiya,  Yukiko Inoue,  Takako Nishikawa,  Natsuko Ohtomo,  Yasushi Tanoue,  Hiromitsu Yokota,  Takatoshi Koyama,  Kazuhiro Ishimaru,  Yasuo Okamoto,  Yoh Takuwa,  Kazuhiko Koike,  Yutaka Yatomi, 
  • Pages: 1427-1438
  • First Published: 13 April 2012
Free Access

Von Willebrand factor as new noninvasive predictor of portal hypertension, decompensation and mortality in patients with liver cirrhosis†

Monika Ferlitsch,  Thomas Reiberger,  Matthias Hoke,  Petra Salzl,  Bernadette Schwengerer,  Gregor Ulbrich,  Berit Anna Payer,  Michael Trauner,  Markus Peck-Radosavljevic,  Arnulf Ferlitsch, 
  • Pages: 1439-1447
  • First Published: 24 April 2012
Free Access

LecT-hepa, a glyco-marker derived from multiple lectins, as a predictor of liver fibrosis in chronic hepatitis C patients†

Kiyoaki Ito,  Atsushi Kuno,  Yuzuru Ikehara,  Masaya Sugiyama,  Hiroaki Saito,  Yoshihiko Aoki,  Teppei Matsui,  Masatoshi Imamura,  Masaaki Korenaga,  Kazumoto Murata,  Naohiko Masaki,  Yasuhito Tanaka,  Shuhei Hige,  Namiki Izumi,  Masayuki Kurosaki,  Shuhei Nishiguchi,  Michiie Sakamoto,  Masayoshi Kage,  Hisashi Narimatsu,  Masashi Mizokami, 
  • Pages: 1448-1456
  • First Published: 26 April 2012

Liver Injury/Regeneration

Free Access

Structural analysis of oval-cell–mediated liver regeneration in rats†

Katalin Dezső,  Veronika Papp,  Edina Bugyik,  Hargita Hegyesi,  Géza Sáfrány,  Csaba Bödör,  Péter Nagy,  Sándor Paku, 
  • Pages: 1457-1467
  • First Published: 15 March 2012
Free Access

Interleukin-33 Is hepatoprotective during liver ischemia/reperfusion in mice†

Nozomu Sakai,  Heather L. Van Sweringen,  R. Cutler Quillin,  Rebecca Schuster,  John Blanchard,  Justin M. Burns,  Amit D. Tevar,  Michael J. Edwards,  Alex B. Lentsch, 
  • Pages: 1468-1478
  • First Published: 10 July 2012
Free Access

Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice†

Johan M. Waern,  Qinggong Yuan,  Urda Rüdrich,  Pablo D. Becker,  Kai Schulze,  Helene Strick-Marchand,  Nicholas D. Huntington,  Behrend J. Zacher,  Karsten Wursthorn,  James P. DiSanto,  Carlos A. Guzman,  Michael P. Manns,  Michael Ott,  Michael Bock, 
  • Pages: 1479-1488
  • First Published: 26 April 2012
Free Access

Analysis of the role of hepatic PPARγ expression during mouse liver regeneration†

Vered Gazit,  Jiansheng Huang,  Alexander Weymann,  David A. Rudnick, 
  • Pages: 1489-1498
  • First Published: 18 June 2012

Liver Biology/Pathobiology

Free Access

Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver†

Wei-Dong Chen,  Xianghui Fu,  Bingning Dong,  Yan-Dong Wang,  Steven Shiah,  David D. Moore,  Wendong Huang, 
  • Pages: 1499-1508
  • First Published: 06 April 2012
Free Access

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver†

Suman Verma,  Phaedra Tachtatzis,  Sue Penrhyn-Lowe,  Cinzia Scarpini,  Diana Jurk,  Thomas Von Zglinicki,  Nick Coleman,  Graeme J. M. Alexander, 
  • Pages: 1510-1520
  • First Published: 13 April 2012
Free Access

Recruitment mechanisms of primary and malignant B cells to the human liver†

Shishir Shetty,  Tony Bruns,  Christopher J. Weston,  Zania Stamataki,  Ye H. Oo,  Heather M. Long,  Gary M. Reynolds,  Guy Pratt,  Paul Moss,  Sirpa Jalkanen,  Stefan G. Hubscher,  Patricia F. Lalor,  David H. Adams, 
  • Pages: 1521-1531
  • First Published: 16 April 2012
Free Access

Two immunogenic passenger dendritic cell subsets in the rat liver have distinct trafficking patterns and radiosensitivities†‡

Bin Yu,  Hisashi Ueta,  Yusuke Kitazawa,  Toshiya Tanaka,  Kensuke Adachi,  Hiromitsu Kimura,  Miwa Morita,  Yasushi Sawanobori,  Hai Xin Qian,  Tatsuhiko Kodama,  Kenjiro Matsuno, 
  • Pages: 1532-1545
  • First Published: 18 April 2012
Free Access

Protein arginine methyltransferase 1 regulates hepatic glucose production in a FoxO1-dependent manner†

Dahee Choi,  Kyoung-Jin Oh,  Hye-Sook Han,  Young-Sil Yoon,  Chang-Yun Jung,  Seong-Tae Kim,  Seung-Hoi Koo, 
  • Pages: 1546-1556
  • First Published: 24 April 2012
Free Access

Hematopoietic chimerism in liver transplantation patients and hematopoietic stem/progenitor cells in adult human liver†

Xiao Qi Wang,  Chung Mau Lo,  Lin Chen,  Cindy K.Y. Cheung,  Zhen Fan Yang,  Yong Xiong Chen,  Michael N. Ng,  Wan Ching Yu,  Xiaoyan Ming,  Wu Zhang,  David W.Y. Ho,  See Ching Chan,  Sheung Tat Fan, 
  • Pages: 1557-1566
  • First Published: 27 April 2012

Reviews

Free Access

Chronic inflammation, immune escape, and oncogenesis in the liver: A unique neighborhood for novel intersections†

Jimmy K. Stauffer,  Anthony J. Scarzello,  Qun Jiang,  Robert H. Wiltrout, 
  • Pages: 1567-1574
  • First Published: 01 March 2012

Hepatology Elsewhere

Free Access

A great time to invest in baby Boomer's hepatitis C!†

Marie-Louise Vachon M.D., M.SC.,  Douglas T. Dieterich M.D., 
  • Pages: 1575-1577
  • First Published: 04 October 2012
Free Access

The role of paracrine signals during liver regeneration†

Ben Z. Stanger M.D., Ph.D.,  Linda Greenbaum M.D., 
  • Pages: 1577-1579
  • First Published: 04 October 2012
Free Access

Nonalcoholic fatty liver disease (NAFLD): Is it really a serious condition?†

Julia Wattacheril MD, MPH,  Naga Chalasani MD, 
  • Pages: 1580-1584
  • First Published: 04 October 2012

Correspondence

Free Access

The mechanism behind the novel fibrosis recently described in NASH in HEPATOLOGY 2011 and Elsewhere†

Theresa C. Hemsworth-Peterson Ph.D., 
  • Page: 1585
  • First Published: 13 April 2012
Free Access

Cholangiocarcinoma: A cancer in search of the right classification†

Vincenzo Cardinale M.D.,  Guido Carpino M.D., Ph.D.,  Lola M. Reid Ph.D.,  Eugenio Gaudio M.D., Ph.D.,  Domenico Alvaro M.D., 
  • Pages: 1585-1586
  • First Published: 12 March 2012
Free Access

Reply†

Mina Komuta M.D., Ph.D.,  Tania Roskams M.D., Ph.D., 
  • Page: 1586
  • First Published: 12 March 2012
Free Access

Antiviral or proviral action of mycophenolic acid in hepatitis B infection?†

Qiuwei Pan,  Anneke J. van Vuuren,  Luc J.W. van der Laan,  Maikel P. Peppelenbosch,  Harry L. A. Janssen, 
  • Pages: 1586-1587
  • First Published: 10 March 2012
Free Access

Paradoxical prosteatotic effect of hedgehog signaling pathway inhibition under conditions of steatosis†

Manuele Gori Ph.D.,  Barbara Barbaro Ph.D.,  Mario Arciello Ph.D.,  Clara Balsano M.D., 
  • Pages: 1587-1588
  • First Published: 20 March 2012
Free Access

Reply:†

Anna Mae Diehl M.D., 
  • Page: 1588
  • First Published: 20 March 2012
Free Access

Hedgehog/hyaluronic acid interaction network in nonalcoholic fatty liver disease, fibrosis, and hepatocellular carcinoma†

Simonetta Pazzaglia M.D.,  Loredana Cifaldi M.D.,  Anna Saran M.D.,  Valerio Nobili M.D.,  Doriana Fruci M.D.,  Anna Alisi Ph.D., 
  • Page: 1589
  • First Published: 13 April 2012
Free Access

To feed or what to feed in cirrhosis?†

Richard D. Johnston MRCP, MSc,  Grace E. Dolman MRCP,  Guruprasad Aithal FRCP, MD, PhD, 
  • Page: 1590
  • First Published: 16 November 2011