• Issue

    Hepatology: Volume 46, Issue 5

    1317-1670
    November 2007
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Editorials

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Good science behind hepatitis C virus antiviral drug development: Necessary but not sufficient†‡

S. Chris Pappas M.D., J.D., 
  • Pages: 1317-1318
  • First Published: 29 October 2007
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TRAILs and tribulation†‡

Harmeet Malhi, 
  • Pages: 1320-1322
  • First Published: 29 October 2007
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Apoptotic cell death takes its toll†‡

Natalie J. Torok, 
  • Pages: 1323-1325
  • First Published: 29 October 2007
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Intrahepatic interferon-stimulated gene responses: Can they predict treatment responses in chronic hepatitis C infection?†‡

Nicholas A. Shackel,  Geoffrey W. McCaughan, 
  • Pages: 1326-1328
  • First Published: 29 October 2007
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Increasing calories, decreasing morbidity and mortality: Is improved nutrition the answer to better outcomes in patients with biliary atresia?†‡

Christine Carter-Kent,  Kadakkal Radhakrishnan,  Ariel E. Feldstein, 
  • Pages: 1329-1331
  • First Published: 29 October 2007

Viral Hepatitis

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The phenotype of hepatitis B virus–specific T cells differ in the liver and blood in chronic hepatitis B virus infection†

J. Judy Chang,  Alexander J. V. Thompson,  Kumar Visvanathan,  Stephen J. Kent,  Paul U. Cameron,  Fiona Wightman,  Paul Desmond,  Stephen A. Locarnini,  Sharon R. Lewin, 
  • Pages: 1332-1340
  • First Published: 29 October 2007
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Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus†‡

John G. McHutchison,  Bruce R. Bacon,  Stuart C. Gordon,  Eric Lawitz,  Mitchell Shiffman,  Nezam H. Afdhal,  Ira M. Jacobson,  Andrew Muir,  Mohammed Al-Adhami,  Mary L. Morris,  Julie A. Lekstrom-Himes,  Susan M. Efler,  Heather L. Davis, 
  • Pages: 1341-1349
  • First Published: 29 October 2007
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Hepatitis C virus genotype 1b as a major risk factor associated with hepatocellular carcinoma in patients with cirrhosis: A seventeen-year prospective cohort study†

Savino Bruno,  Andrea Crosignani,  Patrick Maisonneuve,  Sonia Rossi,  Enrico Silini,  Mario U. Mondelli, 
  • Pages: 1350-1356
  • First Published: 29 October 2007
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Amino acid substitutions in the hepatitis C virus core region are the important predictor of hepatocarcinogenesis†

Norio Akuta,  Fumitaka Suzuki,  Yusuke Kawamura,  Hiromi Yatsuji,  Hitomi Sezaki,  Yoshiyuki Suzuki,  Tetsuya Hosaka,  Masahiro Kobayashi,  Mariko Kobayashi,  Yasuji Arase,  Kenji Ikeda,  Hiromitsu Kumada, 
  • Pages: 1357-1364
  • First Published: 29 October 2007
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Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy†

Marco Binder,  Georg Kochs,  Ralf Bartenschlager,  Volker Lohmann, 
  • Pages: 1365-1374
  • First Published: 29 October 2007
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Features and distribution of CD8 T cells with human leukocyte antigen class I–specific receptor expression in chronic hepatitis C†

Paula Bonorino,  Vincent Leroy,  Tania Dufeu-Duchesne,  Stefania Tongiani-Dashan,  Nathalie Sturm,  Martine Pernollet,  Eric Vivier,  Jean-Pierre Zarski,  Patrice N. Marche,  Evelyne Jouvin-Marche, 
  • Pages: 1375-1386
  • First Published: 29 October 2007

Steatohepatitis/Metabolic Liver Disease

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Incidence and natural course of fatty liver in the general population: The Dionysos study†‡

Giorgio Bedogni,  Lucia Miglioli,  Flora Masutti,  Anna Castiglione,  Lory Saveria Crocè,  Claudio Tiribelli,  Stefano Bellentani, 
  • Pages: 1387-1391
  • First Published: 29 October 2007
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Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet†

Naoto Matsuzawa,  Toshinari Takamura,  Seiichiro Kurita,  Hirofumi Misu,  Tsuguhito Ota,  Hitoshi Ando,  Masayoshi Yokoyama,  Masao Honda,  Yoh Zen,  Yasuni Nakanuma,  Ken-ichi Miyamoto,  Shuichi Kaneko, 
  • Pages: 1392-1403
  • First Published: 29 October 2007
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Role of αvβ6 integrin in acute biliary fibrosis†

Bruce Wang,  Brian M. Dolinski,  Noriko Kikuchi,  Diane R. Leone,  Marion G. Peters,  Paul H. Weinreb,  Shelia M. Violette,  D. Montgomery Bissell, 
  • Pages: 1404-1412
  • First Published: 29 October 2007
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Glycine N-methyltransferase−/− mice develop chronic hepatitis and glycogen storage disease in the liver†

Shih-Ping Liu,  Ying-Shiuan Li,  Yann-Jang Chen,  En-Pei Chiang,  Anna Fen-Yau Li,  Ying-Hue Lee,  Ting-Fen Tsai,  Michael Hsiao,  Shiu-Feng Hwang,  Yi-Ming Arthur Chen, 
  • Pages: 1413-1425
  • First Published: 29 October 2007

Hepatobiliary Malignancies

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N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus†

Xue-En Liu,  Liesbeth Desmyter,  Chun-Fang Gao,  Wouter Laroy,  Sylviane Dewaele,  Valerie Vanhooren,  Ling Wang,  Hui Zhuang,  Nico Callewaert,  Claude Libert,  Roland Contreras,  Cuiying Chen, 
  • Pages: 1426-1435
  • First Published: 29 October 2007

Autoimmune, Cholestatic and Biliary Disease

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Antimitochondrial antibodies in acute liver failure: Implications for primary biliary cirrhosis†

Patrick S. C. Leung,  Lorenzo Rossaro,  Paul A. Davis,  Ogyi Park,  Atsushi Tanaka,  Kentaro Kikuchi,  Hiroshi Miyakawa,  Gary L. Norman,  William Lee,  M. Eric Gershwin,  Acute Liver Failure Study Group , 
  • Pages: 1436-1442
  • First Published: 29 October 2007
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Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis†

Ali Mencin,  Ekihiro Seki,  Yosuke Osawa,  Yuzo Kodama,  Samuele De Minicis,  Michael Knowles,  David A. Brenner, 
  • Pages: 1443-1452
  • First Published: 29 October 2007
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Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: Results of a prospective, randomized, double-blind, placebo-controlled, multicenter trial†‡

James H. Lewis,  Mary Ellen Mortensen,  Steven Zweig,  Mary Jean Fusco,  Jeffrey R. Medoff,  Rene Belder,  Pravastatin in Chronic Liver Disease Study Investigators , 
  • Pages: 1453-1463
  • First Published: 29 October 2007

Liver Failure/Cirrhosis/Portal Hypertension

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Sinusoidal endothelial cell repopulation following ischemia/reperfusion injury in rat liver transplantation†

Donna Beer Stolz,  Mark A. Ross,  Atsushi Ikeda,  Koji Tomiyama,  Takashi Kaizu,  David A. Geller,  Noriko Murase, 
  • Pages: 1464-1475
  • First Published: 29 October 2007
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Outcomes of donor evaluation in adult-to-adult living donor liver transplantation†‡

James F. Trotter,  Karen A. Wisniewski,  Norah A. Terrault,  James E. Everhart,  Milan Kinkhabwala,  Robert M. Weinrieb,  Jeffrey H. Fair,  Robert A. Fisher,  Alan J. Koffron,  Sammy Saab,  Robert M. Merion,  A2ALL Study Group , 
  • Pages: 1476-1484
  • First Published: 29 October 2007
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Decreased white matter lesion volume and improved cognitive function after liver transplantation†

Alex Rovira,  Beatriz Mínguez,  F. Xavier Aymerich,  Carlos Jacas,  Elena Huerga,  Juan Córdoba,  Juli Alonso, 
  • Pages: 1485-1490
  • First Published: 29 October 2007
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Survival after liver transplantation: Is racial disparity inevitable?†

Tae Hoon Lee,  Nilay Shah,  Rachel A. Pedersen,  Walter K. Kremers,  Charles B. Rosen,  Goran B. Klintmalm,  W. Ray Kim, 
  • Pages: 1491-1497
  • First Published: 29 October 2007

Liver Injury/Regeneration

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Increased hepatotoxicity of tumor necrosis factor–related apoptosis-inducing ligand in diseased human liver†

Xandra Volkmann,  Ute Fischer,  Matthias J. Bahr,  Michael Ott,  Frank Lehner,  Marion MacFarlane,  Gerald M. Cohen,  Michael P. Manns,  Klaus Schulze-Osthoff,  Heike Bantel, 
  • Pages: 1498-1508
  • First Published: 29 October 2007
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Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9†

Azuma Watanabe,  Ardeshir Hashmi,  Dawidson Assis Gomes,  Terrence Town,  Abdallah Badou,  Richard Anthony Flavell,  Wajahat Zafar Mehal, 
  • Pages: 1509-1518
  • First Published: 29 October 2007
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A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury†

Xiong Ma,  Jing Hua,  Abdiaziz R. Mohamood,  Abdel Rahmin A. Hamad,  Rajani Ravi,  Zhiping Li, 
  • Pages: 1519-1529
  • First Published: 29 October 2007
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The role of serpinb9/serine protease inhibitor 6 in preventing granzyme B–dependent hepatotoxicity†

Heather W. Stout-Delgado,  Yonas Getachew,  Thomas E. Rogers,  Bonnie C. Miller,  Dwain L. Thiele, 
  • Pages: 1530-1540
  • First Published: 29 October 2007
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The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha-fetoprotein regulator 2†

Lorri A. Morford,  Christina Davis,  Lin Jin,  Aneta Dobierzewska,  Martha L. Peterson,  Brett T. Spear, 
  • Pages: 1541-1547
  • First Published: 29 October 2007

Liver Biology/Pathobiology

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Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response†

Jordan J. Feld,  Santosh Nanda,  Ying Huang,  Weiping Chen,  Maggie Cam,  Susan N. Pusek,  Lisa M. Schweigler,  Dickens Theodore,  Steven L. Zacks,  T. Jake Liang,  Michael W. Fried, 
  • Pages: 1548-1563
  • First Published: 29 October 2007
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Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice†

Ryotaro Sakamori,  Tetsuo Takehara,  Chihiro Ohnishi,  Tomohide Tatsumi,  Kazuyoshi Ohkawa,  Kiyoshi Takeda,  Shizuo Akira,  Norio Hayashi, 
  • Pages: 1564-1573
  • First Published: 29 October 2007
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Human skin fibroblasts: From mesodermal to hepatocyte-like differentiation†

Philippe A. Lysy,  Françoise Smets,  Catherine Sibille,  Mustapha Najimi,  Etienne M. Sokal, 
  • Pages: 1574-1585
  • First Published: 29 October 2007
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Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes†

Cheng Ji,  Masao Shinohara,  John Kuhlenkamp,  Christine Chan,  Neil Kaplowitz, 
  • Pages: 1586-1596
  • First Published: 29 October 2007
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Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor-E2–related factor-2 transcriptional pathway†

Jonathan M. Maher,  Matthew Z. Dieter,  Lauren M. Aleksunes,  Angela L. Slitt,  Grace Guo,  Yuji Tanaka,  George L. Scheffer,  Jefferson Y. Chan,  Jose E. Manautou,  Ying Chen,  Timothy P. Dalton,  Masayuki Yamamoto,  Curtis D. Klaassen, 
  • Pages: 1597-1610
  • First Published: 29 October 2007
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Bile duct destruction by 4,4′-diaminodiphenylmethane does not block the small hepatocyte-like progenitor cell response in retrorsine-exposed rats†

D. Hunter Best,  William B. Coleman, 
  • Pages: 1611-1619
  • First Published: 29 October 2007
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ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride–induced hepatic fibrosis in mice†

Frédéric Kesteloot,  Alexis Desmoulière,  Isabelle Leclercq,  Marc Thiry,  Jorge E. Arrese,  Darwin J. Prockop,  Charles M. Lapière,  Betty V. Nusgens,  Alain Colige, 
  • Pages: 1620-1631
  • First Published: 29 October 2007

Special Article

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Growth failure and outcomes in infants with biliary atresia: A report from the Biliary Atresia Research Consortium†

Patricia A. DeRusso,  Wen Ye,  Ross Shepherd,  Barbara A. Haber,  Benjamin L. Shneider,  Peter F. Whitington,  Kathleen B. Schwarz,  Jorge A. Bezerra,  Philip Rosenthal,  Saul Karpen,  Robert H. Squires,  John C. Magee,  Patricia R. Robuck,  Ronald J. Sokol,  Biliary Atresia Research Consortium , 
  • Pages: 1632-1638
  • First Published: 29 October 2007

Reviews

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Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies†

Nam-On Ku,  Pavel Strnad,  Bi-Hui Zhong,  Guo-Zhong Tao,  M. Bishr Omary, 
  • Pages: 1639-1649
  • First Published: 29 October 2007
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The liver in celiac disease†

Alberto Rubio-Tapia,  Joseph A. Murray, 
  • Pages: 1650-1658
  • First Published: 29 October 2007

Hepatology Elsewhere

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Liver fibrosis: The hepatocyte revisited†

Mark D. Gorrell PH.D., 
  • Pages: 1659-1661
  • First Published: 29 October 2007
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Genomewide genetic association studies in hepatology: The end of searching for the needle in the haystack?†‡

Claus Hellerbrand,  Hermann E. Wasmuth, 
  • Pages: 1661-1663
  • First Published: 29 October 2007

Correspondence

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Changes in bile acid synthesis in gallstone disease: Cause, consequence, or neither?†

Marco Bertolotti,  Chiara Gabbi,  Claudia Anzivino,  Lucia Carulli,  Nicola Carulli, 
  • Page: 1664
  • First Published: 29 October 2007
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Reply:†

Silvana Zanlungo,  Juan Francisco Miquel,  Flavio Nervi, 
  • Pages: 1664-1665
  • First Published: 29 October 2007
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Does hepatitis B viral load determine the outcome of patients with hepatocellular carcinoma undergoing chemotherapy?†

Teh-Ia Huo,  Jaw-Ching Wu,  Shou-Dong Lee, 
  • Pages: 1665-1666
  • First Published: 29 October 2007
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Reply:†

Winnie Yeo,  Frankie K. F. Mo, 
  • Page: 1666
  • First Published: 29 October 2007
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Dipsticks for spontaneous bacterial peritonitis: Comments on a long-awaited study report†

Anastasios Koulaouzidis M.D. MRCP,  Elmuhtady Said MBBS,  Anthia Gatopoulou M.D., Ph.D.,  John Moschos M.D., Ph.D., 
  • Pages: 1666-1667
  • First Published: 29 October 2007
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Spontaneous bacterial peritonitis and reagent strips†

Jose Castellote, 
  • Pages: 1667-1668
  • First Published: 29 October 2007
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Lower cutoff values for dipsticks may improve their accuracy in rapid diagnosis of spontanous bacterial peritonitis†

Antonio de Barros Lopes,  Alexandre Araujo,  Mario Reis Alvares-da Silva, 
  • Page: 1668
  • First Published: 29 October 2007
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Insufficient sensitivity of reagent strips for spontaneous bacterial peritonitis†

Veit Gülberg,  Alexander L. Gerbes,  Tilman Sauerbruch,  Beate Appenrodt, 
  • Page: 1669
  • First Published: 29 October 2007
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Reply:†

Jean-Baptiste Nousbaum,  Jean-François Cadranel,  Club Francophone pour l'Etude de l'Hypertension Portale and l'Association Nationale des Hépato-Gastroentérologues des Hôpitaux Généraux de France , 
  • Pages: 1669-1670
  • First Published: 29 October 2007