• Issue

    Liver International: Volume 45, Issue 9

    September 2025
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ISSUE INFORMATION

Free Access

Issue Information

  • First Published: 29 July 2025

ORIGINAL ARTICLE

Open Access

The Medical Impact of Hepatitis D Virus Infection in Natives and Immigrants: The Italian Paradigm

Gian Paolo Caviglia, Eleonora Dileo, Antonella Olivero, Giulio Mengozzi, Alessia Ciancio, Alessandro Loglio, Mauro Viganò, Stefano Fagiuoli, Piero Colombatto, Barbara Coco, Maurizia Rossana Brunetto, Debora Angrisani, Alfonso Galeota Lanza, Carlo Magni, Giuliano Rizzardini, Vincenzo Messina, Michele Milella, Annalisa Saracino, Letizia Marinaro, Giuseppe Cariti, Valentina Cossiga, Filomena Morisco, Silvia Cretella, Gabriella Verucchi, Elisa Biliotti, Giampiero D'Offizi, Marcello Feasi, Emanuele Pontali, Carmine Coppola, Rachele Rapetti, Mario Pirisi, Antonio Izzi, Teresa Santantonio, Vito Di Marco, Aldo Marrone, Nicola Coppola, Marco Rizzi, Anna Maria Cattelan, Grazia Anna Niro, Pierluigi Toniutto, Francesca Romana Ponziani, Luca Saverio Belli, Alessandro Federico, Gaetano Bertino, Michele Barone, Massimo Puoti, Alberto Civolani, Marco Distefano, Lorenzo Antonio Surace, Raffaele Cozzolongo, Ester Marina Cela, Elisabetta Teti, Pietro Lampertico, Tommaso Stroffolini, Mario Rizzetto,  on behalf of the HDV Describe Study Group , 
  • First Published: 29 July 2025

LETTER TO THE EDITOR

Response to: From Image to Insight: Is MRI-Based Genotyping Ready for the Clinic?

Yazhou Chen,  Benjamin P. M. Laevens,  Carolin V. Schneider, 
  • First Published: 29 July 2025

Nanoplastics and MASLD: Unveiling Interorgan Crosstalk and Environmental Modulators

Yanbin Xue,  Linghui Tao, 
  • First Published: 30 July 2025

ORIGINAL ARTICLE

Open Access

Glucagon-Like Peptide-1 Receptor Agonists Improve MASH and Liver Fibrosis: A Meta-Analysis of Randomised Controlled Trials

Alessandro Mantovani,  Riccardo Morandin,  Veronica Fiorio,  Maria Giovanna Lando,  Norbert Stefan,  Herbert Tilg,  Christopher D. Byrne,  Giovanni Targher, 
  • First Published: 30 July 2025
Open Access

Phenotypic Divergence of JAG1- and NOTCH2-Associated Alagille Syndrome & Disease-Specific NOTCH2 Variant Classification Guidelines

Shannon M. Vandriel,  Li-Ting Li,  Huiyu She,  Jian-She Wang,  Kathleen M. Loomes,  David A. Piccoli,  Irena Jankowska,  Piotr Czubkowski,  Dorota Gliwicz-Miedzińska,  Lorenzo D'Antiga,  Emanuele Nicastro,  Florence Lacaille,  Dominique Debray,  Étienne M. Sokal,  Tanguy Demaret,  Rima L. Fawaz,  Silvia Nastasio,  Kyung Mo Kim,  Seak Hee Oh,  Björn Fischler,  Henrik Arnell,  Catherine Larson-Nath,  Winita Hardikar,  Sahana Shankar,  Shikha S. Sundaram,  Alexander Chaidez,  Pinar Bulut,  Pier Luigi Calvo,  Mureo Kasahara,  Niviann Blondet,  Eberhard Lurz,  Anna-Maria Kavallar,  Emmanuel M. Gonzales,  Emmanuel Jacquemin,  Jérôme Bouligand,  Noelle H. Ebel,  Jeffrey A. Feinstein,  Susan M. Siew,  Michael O. Stormon,  Saul J. Karpen,  Rene Romero,  M. Kyle Jensen,  Catalina Jaramillo,  James E. Squires,  Sarah M. Bedoyan,  Deirdre A. Kelly,  Jane Hartley,  Henkjan J. Verkade,  Way Seah Lee,  Chatmanee Lertudomphonwanit,  Ryan T. Fischer,  Henry C. Lin,  Nathalie Rock,  Yael Mozer-Glassberg,  Amin J. Roberts,  Helen M. Evans,  Wikrom Karnsakul,  Gabriella Nebbia,  Victorien M. Wolters,  Pamela L. Valentino,  Jesus Quintero Bernabeu,  Amal A. Aqul,  Cigdem Arikan,  María Legarda Tamara,  Cristina Molera Busoms,  Thomas Damgaard Sandahl,  Giuseppe Indolfi,  Andréanne N. Zizzo,  Aglaia Zellos,  Ruben E. Quiros-Tejeira,  Ermelinda Santos-Silva,  Kathleen B. Schwarz,  Jernej Brecelj,  Maria Camila Sanchez,  Maria Lorena Cavalieri,  Christos Tzivinikos,  Sabina Wiecek,  John Eshun,  Nanda Kerkar,  Quais Mujawar,  Zerrin Önal,  Cristina Gonçalves,  Jennifer Garcia,  Seema Alam,  Carolina Jimenez-Rivera,  Luis Bujanda,  Richard J. Thompson,  Bettina E. Hansen,  Nancy B. Spinner,  Melissa A. Gilbert,  Binita M. Kamath,  The Global ALagille Alliance (GALA) Study Group , 
  • First Published: 31 July 2025

A Novel Score for Predicting Long-Term Outcomes in Recanalisation-Treated Patients With Budd-Chiari Syndrome: A Multicentre Study

Dongdong Xia,  Bohan Luo,  Qiuhe Wang,  Chunqing Zhang,  Kewei Zhang,  Mingxing Li,  Qingyong Fan,  Qiaozheng Wang,  Wei Bai,  Kai Li,  Wengang Guo,  Jiahao Fan,  Guangchuan Wang,  Aiyuan Xiu,  Zhengyu Wang,  Jie Yuan,  Yong Lv,  Menghao Li,  Bing Li,  Zenghui Dong,  Na Zhang,  Yiwei Shang,  Wei Dai,  Yalan Wang,  Hong Tang,  Zhanxin Yin,  Yan Zhao,  Jielai Xia,  Daiming Fan,  Ke Xu,  Kaichun Wu,  Guohong Han, 
  • First Published: 02 August 2025

Endothelial Tgfbr2 Deficiency Ameliorate Liver Fibrosis Through Regulating Angiocrine Signalling and Macrophage Accumulation

Ru Huang,  Juan Deng,  Ke-Qi Wang,  Chang-Peng Zhu,  Chen-Hong Ding,  Fei Chen,  Xin Zhang,  Wei-Fen Xie, 
  • First Published: 01 August 2025
Summary

TGFBR2 expression in LSEC is elevated in cirrhotic patients and murine fibrotic liver tissues.

Endothelial-specific Tgfbr2 deletion reshapes angiocrine signalling, inhibits proinflammatory monocyte recruitment and attenuates hepatic inflammation during liver fibrosis.

Open Access

Design and Analysis of Novel HEV Vaccine Variants and Evaluation of Two Selected Candidates in a Porcine Infection Model

Isabella Hrabal,  Elmira Aliabadi,  Saskia Weber,  George Liam Ssebyatika,  Thomas Krey,  Cora M. Holicki,  Laura Schmid,  Katja Dinkelborg,  Charlotte Schröder,  Christine Fast,  Patrick Behrendt,  Martin H. Groschup,  Martin Eiden, 
  • First Published: 01 August 2025
Open Access

Pharmacological Inhibition of c-Jun N-Terminal Kinase Activity Exacerbates Liver Damage in Schistosoma mansoni Infected Mice

Frederik Stettler,  Lukas Knedla,  Maximilian Hagen,  Verena von Bülow,  Heike Müller,  Annette Tschuschner,  Daniel Zahner,  Simone Haeberlein,  Max F. Moescheid,  Anita Windhorst,  Monika Burg-Roderfeld,  Dieter Glebe,  Bernardo Pereira Moreira,  Céline Lesieur,  Andreas Schmid,  Franco H. Falcone,  Christoph G. Grevelding,  Elke Roeb,  Martin Roderfeld, 
  • First Published: 02 August 2025

LETTER TO THE EDITOR

TIPS Superiority in Refractory Variceal Haemorrhage: Insights From the TIPSEMS-VB Trial

Junzhen Li,  Yingjie Wu, 
  • First Published: 02 August 2025

REVIEW

Open Access

Fifteen Years of PNPLA3: Transforming Hepatology Through Human Genetics

Stefano Romeo,  Luca Valenti, 
  • First Published: 01 August 2025

LETTER TO THE EDITOR

Socio-Economic and Geographic Factors in Liver Disease Progression Among Individuals With HIV–HBV Coinfection

Zhixi Xiao,  Zhengrui Li,  Qingyu Chen, 
  • First Published: 29 July 2025

ORIGINAL ARTICLE

Knockdown of Salusin-β Downregulates FTO to Inhibit Lipid Synthesis and Promote Lipolysis to Attenuate NAFLD

Jintong Pan,  Wei Ye,  Jinmeng Zhang,  Ye Fan,  Zaohong Chen,  Yuxue Wang,  Xiang Liu, 
  • First Published: 29 July 2025