• Issue

    Liver International: Volume 42, Issue 1

    i-iii, 1-261
    January 2022
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ISSUE COVER

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Issue Cover

Feng Gao,  Qiong He,  Gang Li,  Ou-Yang Huang,  Liang-Jie Tang,  Xiao-Dong Wang,  Giovanni Targher,  Christopher D. Byrne,  Jian-Wen Luo,  Ming-Hua Zheng, 
  • Page: i
  • First Published: 29 December 2021
Issue Cover

The cover image is based on the Original Article A novel quantitative ultrasound technique for identifying non-alcoholic steatohepatitis by Feng Gao et al., https://doi.org/10.1111/liv.15064.

INSIDE FRONT COVER

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Inside Front Cover

Paolo Ventura,  Herbert L. Bonkovsky,  Laurent Gouya,  Paula Aguilera-Peiró,  D. Montgomery Bissell,  Penelope E. Stein,  Manisha Balwani,  D. Karl E. Anderson,  Charles Parker,  David J. Kuter,  Susana Monroy,  Jeeyoung Oh,  Bruce Ritchie,  John J. Ko,  Zhaowei Hua,  Marianne T. Sweetser,  Eliane Sardh,  for the ENVISION Investigators , 
  • Page: ii
  • First Published: 19 January 2022
Inside Front Cover

The cover image is based on the Original Article Efficacy and safety of givosiran for acute hepatic porphyria: 24-month interim analysis of the randomized phase 3 ENVISION study by Paolo Ventura et al., https://doi.org/10.1111/liv.15090.

BACK COVER

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Back Cover

Beiling Li,  Qinjun He,  Yongyu Rui,  Yan Chen,  Rajiv Jalan,  Jinjun Chen, 
  • Page: iii
  • First Published: 19 January 2022
Back Cover

The cover image is based on the Brief Definitive Report Rapid detection for infected ascites in cirrhosis using metagenome next-generation sequencing: A case series by Beiling Li et al., https://doi.org/10.1111/liv.15083.

ISSUE INFORMATION

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Issue Information

  • Pages: 1-5
  • First Published: 29 December 2021

EDITORIAL

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Binge drinking and fibrogenesis: More than just a hangover

Avik Majumdar,  Emmanuel A. Tsochatzis, 
  • Pages: 6-8
  • First Published: 29 December 2021

REVIEWS & META-ANALYSES

Free Access

Gamma-Glutamyl Transferase (γ-GT) – an old dog with new tricks?

Paul N. Brennan,  John F. Dillon,  Elliot B. Tapper, 
  • Pages: 9-15
  • First Published: 14 November 2021

LIVER DISEASE AND PUBLIC HEALTH

Free to Read

The price tag of a potential cure for chronic hepatitis B infection: A cost threshold analysis for USA, China and Australia

Mehlika Toy,  David Hutton,  Karen McCulloch,  Nicole Romero,  Peter A. Revill,  M-Capucine Penicaud,  Samuel So,  Benjamin C. Cowie, 
  • Pages: 16-25
  • First Published: 30 July 2021
Open Access

Optimizing diagnostic algorithms to advance Hepatitis C elimination in Italy: A cost effectiveness evaluation

Andrea Marcellusi,  Francesco Saverio Mennini,  Murad Ruf,  Claudio Galli,  Alessio Aghemo,  Maurizia R. Brunetto,  Sergio Babudieri,  Antonio Craxi,  Massimo Andreoni,  Loreta A. Kondili, 
  • Pages: 26-37
  • First Published: 28 September 2021

VIRAL HEPATITIS

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Late presentation for HCV care: Time to target people with diabetes and/or hazardous alcohol use (ANRS CO22 HEPATHER cohort)

Melina Santos,  Camelia Protopopescu,  Elizabeth Delarocque-Astagneau,  Marc Bourlière,  Ventizlava Petrov-Sanchez,  Vincent Di Beo,  Dominique Larrey,  Maël Baudoin,  Céline Dorival,  Morgane Bureau,  Hélène Fontaine,  Fabrice Carrat,  Fabienne Marcellin,  Stanislas Pol,  Patrizia Carrieri,  the ANRS CO22 HEPATHER study group , 
  • Pages: 38-49
  • First Published: 14 September 2021
Open Access

Maternal and fetal outcomes of pregnancies complicated by acute hepatitis E and the impact of HIV status: A cross-sectional study in Namibia

Steffie Heemelaar,  Anna L. Hangula,  Melody L. Chipeio,  Mirjam Josef,  Jelle Stekelenburg,  Thomas H. van den Akker,  Sven Pischke,  Shonag B. P. Mackenzie, 
  • Pages: 50-58
  • First Published: 08 October 2021
Free to Read

On-treatment gamma-glutamyl transferase predicts the development of hepatocellular carcinoma in chronic hepatitis B patients

Chung-Feng Huang,  Tyng-Yuan Jang,  Dae Won Jun,  Sang Bong Ahn,  Jihyun An,  Masaru Enomoto,  Hirokazu Takahashi,  Eiichi Ogawa,  Eileen Yoon,  Soung Won Jeong,  Jae-Jun Shim,  Jae Yoon Jeong,  Sung Eun Kim,  Hyunwoo Oh,  Hyoung Su Kim,  Yong Kyun Cho,  Ritsuzo Kozuka,  Kaori Inoue,  Ka Shing Cheung,  Lung Yi Mak,  Jee-Fu Huang,  Chia-Yen Dai,  Man-Fung Yuen,  Mindie H. Nguyen,  Ming-Lung Yu, 
  • Pages: 59-68
  • First Published: 23 October 2021

METABOLIC & TOXIC LIVER DISEASES

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Higher dietary insulinaemic potential is associated with increased risk of liver steatosis and fibrosis

Yu Zhu,  Zhaohong Peng,  Yao Lu,  Hairong Li,  Xufen Zeng,  Zhuang Zhang,  Xiude Li,  Chunqiu Hu,  Anla Hu,  Qihong Zhao,  Hua Wang,  Wanshui Yang, 
  • Pages: 69-79
  • First Published: 14 September 2021
Free to Read

A novel quantitative ultrasound technique for identifying non-alcoholic steatohepatitis

Feng Gao,  Qiong He,  Gang Li,  Ou-Yang Huang,  Liang-Jie Tang,  Xiao-Dong Wang,  Giovanni Targher,  Christopher D. Byrne,  Jian-Wen Luo,  Ming-Hua Zheng, 
  • Pages: 80-91
  • First Published: 26 September 2021
Free to Read

Binge drinking induces an acute burst of markers of hepatic fibrogenesis (PRO-C3)

Nikolaj Torp,  Mads Israelsen,  Mette J. Nielsen,  Claus P. Åstrand,  Pernille Juhl,  Stine Johansen,  Camilla D. Hansen,  Bjørn Madsen,  Ida F. Villesen,  Diana J. Leeming,  Maja Thiele,  Torben Hansen,  Morten Karsdal,  Aleksander Krag, 
  • Pages: 92-101
  • First Published: 30 November 2021
Binge drinking induces an acute burst of markers of hepatic fibrogenesis (PRO-C3)

Overview of study design and main finding where PRO-C3 increased in all study groups following a single binge drinking episode. Permission to reproduce material from other sources: Graphical abstract created with BioRender.com reproduced with permission.

Open Access

Inflammatory activity affects the accuracy of liver stiffness measurement by transient elastography but not by two-dimensional shear wave elastography in non-alcoholic fatty liver disease

Yuly P. Mendoza,  Susana G. Rodrigues,  Maria G. Delgado,  Giuseppe Murgia,  Naomi F. Lange,  Jonas Schropp,  Matteo Montani,  Jean-François Dufour,  Annalisa Berzigotti, 
  • Pages: 102-111
  • First Published: 25 November 2021

GUT-LIVER AXIS, IMMUNOLOGY, IMMUNE MEDIATED AND CHOLESTATIC DISEASES

Open Access

Seladelpar improved measures of pruritus, sleep, and fatigue and decreased serum bile acids in patients with primary biliary cholangitis

Andreas E. Kremer,  Marlyn J. Mayo,  Gideon Hirschfield,  Cynthia Levy,  Christopher L. Bowlus,  David E. Jones,  Alexandra Steinberg,  Charles A. McWherter,  Yun-Jung Choi, 
  • Pages: 112-123
  • First Published: 17 August 2021
Free to Read

Bile acid dysmetabolism in the gut-microbiota-liver axis under hepatitis C virus infection

Takako Inoue,  Yui Funatsu,  Masaya Ohnishi,  Masanori Isogawa,  Keigo Kawashima,  Masaru Tanaka,  Kei Moriya,  Hideto Kawaratani,  Rie Momoda,  Etsuko Iio,  Hidewaki Nakagawa,  Yutaka Suzuki,  Kentaro Matsuura,  Kei Fujiwara,  Atsushi Nakajima,  Hitoshi Yoshiji,  Jiro Nakayama,  Yasuhito Tanaka, 
  • Pages: 124-134
  • First Published: 19 August 2021
Free to Read

The effect of biliary obstruction, biliary drainage and bile reinfusion on bile acid metabolism and gut microbiota in mice

Rui Wu,  Yangqianwen Zhang,  Qingbao Cheng,  Jianmin Wu,  Yanjing Zhu,  Xuebing Shi,  Xinyao Qiu,  Shuai Yang,  Shan Wang,  Bo Zheng,  Tong Wu,  Zhixuan Li,  Kaiting Wang,  Yani Zhang,  Yan Zhao,  Wenwen Wang,  Jinxia Bao,  Ji Hu,  Xuan Wu,  Hongyang Wang,  Xiaoqing Jiang,  Lei Chen, 
  • Pages: 135-148
  • First Published: 30 August 2021

GENETICS AND RARE LIVER DISEASES

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Association of genetic variations with NAFLD in lean individuals

Huapeng Lin,  Grace L.-H. Wong,  Carl Whatling,  Anthony W.-H. Chan,  Howard H.-W. Leung,  Chi-Hang Tse,  Sally S.-T. Shu,  Angel M.-L. Chim,  Jimmy C.-T. Lai,  Terry C.-F. Yip,  Vincent W.-S. Wong, 
  • Pages: 149-160
  • First Published: 05 October 2021
Open Access

Efficacy and safety of givosiran for acute hepatic porphyria: 24-month interim analysis of the randomized phase 3 ENVISION study

Paolo Ventura,  Herbert L. Bonkovsky,  Laurent Gouya,  Paula Aguilera-Peiró,  D. Montgomery Bissell,  Penelope E. Stein,  Manisha Balwani,  D. Karl E. Anderson,  Charles Parker,  David J. Kuter,  Susana Monroy,  Jeeyoung Oh,  Bruce Ritchie,  John J. Ko,  Zhaowei Hua,  Marianne T. Sweetser,  Eliane Sardh,  for the ENVISION Investigators , 
  • Pages: 161-172
  • First Published: 30 October 2021
Efficacy and safety of givosiran for acute hepatic porphyria: 24-month interim analysis of the randomized phase 3 ENVISION study

CIRRHOSIS, LIVER FAILURE AND TRANSPLANTATION

Free to Read

Rapid detection for infected ascites in cirrhosis using metagenome next-generation sequencing: A case series

Beiling Li,  Qinjun He,  Yongyu Rui,  Yan Chen,  Rajiv Jalan,  Jinjun Chen, 
  • Pages: 173-179
  • First Published: 23 October 2021
Free to Read

Coordinated cellular and humoral immune responses after two-dose SARS-CoV2 mRNA vaccination in liver transplant recipients

Gianpiero D’Offizi,  Chiara Agrati,  Ubaldo Visco-Comandini,  Concetta Castilletti,  Vincenzo Puro,  Paola Piccolo,  Marzia Montalbano,  Silvia Meschi,  Eleonora Tartaglia,  Chiara Sorace,  Sara Leone,  Daniele Lapa,  Germana Grassi,  Delia Goletti,  Giuseppe Ippolito,  Francesco Vaia,  Giuseppe Maria Ettorre,  Raffaella Lionetti, 
  • Pages: 180-186
  • First Published: 31 October 2021
Free to Read

Practice patterns and outcomes associated with intravenous albumin in patients with cirrhosis and acute kidney injury

Kavish R. Patidar,  Mohammad Adibuzzaman,  Mobasshir A. Naved,  Dylan Rodriquez,  James E. Slaven,  Ananth Grama,  Archita P. Desai,  Eduardo V. Gomez,  Marwan S. Ghabril,  Lauren Nephew,  Niharika R. Samala,  Melissa Anderson,  Naga P. Chalasani,  Eric S. Orman, 
  • Pages: 187-198
  • First Published: 14 November 2021

LIVER CANCER

Free to Read

Lung and lymph node metastases from hepatocellular carcinoma: Comparison of pathological aspects

Ha Young Woo,  Hyungjin Rhee,  Jeong Eun Yoo,  Se Hoon Kim,  Gi Hong Choi,  Do Young Kim,  Hyun Goo Woo,  Hye Sun Lee,  Young Nyun Park, 
  • Pages: 199-209
  • First Published: 07 September 2021
Free to Read

Validation of the GALAD model for early diagnosis and monitoring of hepatocellular carcinoma in Chinese multicenter study

Chenjun Huang,  Meng Fang,  Xiao Xiao,  Hong Wang,  Zhiyuan Gao,  Jun Ji,  Lijuan Liu,  Erli Gu,  Ya Li,  Mengmeng Wang,  Chunfang Gao, 
  • Pages: 210-223
  • First Published: 22 October 2021
Free to Read

Risk factors for bleeding hepatocellular adenoma in a United States cohort

Chelsea McDermott,  Marco Ertreo,  Reena Jha,  Jimin Ko,  Stephen Fernandez,  Sameer Desale,  Thomas Fishbein,  Rohit Satoskar,  Emily Winslow,  Coleman Smith,  Christine C Hsu, 
  • Pages: 224-232
  • First Published: 23 October 2021

EXPERIMENTAL HEPATOLOGY

Open Access

The protease-inhibitor SerpinB3 as a critical modulator of the stem-like subset in human cholangiocarcinoma

Margherita Correnti,  Andrea Cappon,  Mirella Pastore,  Benedetta Piombanti,  Giulia Lori,  Douglas V. P. N. Oliveira,  Patricia Munoz-Garrido,  Monika Lewinska,  Jesper B. Andersen,  Cédric Coulouarn,  Laurent Sulpice,  Caterina Peraldo Neia,  Giuliana Cavalloni,  Santina Quarta,  Alessandra Biasiolo,  Matteo Fassan,  Matteo Ramazzotti,  Matteo Parri,  Stefania Recalcati,  Luca di Tommaso,  Claudia Campani,  Pietro Invernizzi,  Guido Torzilli,  Fabio Marra,  Patrizia Pontisso,  Chiara Raggi, 
  • Pages: 233-248
  • First Published: 03 September 2021

RESEARCH LETTERS

Free to Read

Hepatitis Delta virus in migrants: The challenge of elimination (ANRS CO22 HEPATHER cohort)

Marta Lotto,  Hélène Fontaine,  Fabienne Marcellin,  Lauren Périères,  Morgane Bureau-Stoltmann,  Fabrice Carrat,  Stanislas Pol,  Fabien Zoulim,  Patrizia Carrieri, 
  • Pages: 249-252
  • First Published: 26 November 2021

LETTERS TO THE EDITOR

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Improvement in adipocytic indices as a predictor of improved outcomes after TIPS: Right conclusion?

Srikant Mohta MD, DM,  Sanchit Sharma MD, DM,  Anoop Saraya MD, DM, DNB, 
  • Page: 253
  • First Published: 01 November 2021
Free to Read

A typical autoimmune hepatitis (AIH) case following Covid-19 mRNA vaccination. More than a coincidence?

Anestis Goulas,  Georgia Kafiri,  Hariklia Kranidioti,  Spilios Manolakopoulos, 
  • Pages: 254-255
  • First Published: 01 November 2021
Free to Read

Impact of COVID – 19 in patients awaiting liver transplantation

Ilias Kounis,  Lea Duhaut,  Thomas Breard,  Didier Samuel,  Audrey Coilly, 
  • Pages: 256-257
  • First Published: 19 November 2021
Free to Read

Albumin for AKI in cirrhosis – Sham therapy or effective?

Suprabhat Giri,  Sunil Kasturi,  Harish Darak, 
  • Pages: 258-259
  • First Published: 24 November 2021
Free to Read

NAFLD vs ALD: The unresolved duel between the bad and the worst

Suprabhat Giri, 
  • Pages: 260-261
  • First Published: 04 December 2021