• Issue

    Diabetic Medicine: Volume 33, Issue 9

    1165-1304, e17-e25
    September 2016
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Issue Information

Free Access

Table of Contents 1

  • Page: 1165
  • First Published: 17 August 2016
Free Access

Table of Contents 2

  • Page: 1167
  • First Published: 17 August 2016
Free Access

Aims and Scope

  • Page: 1168
  • First Published: 17 August 2016
Free Access

Editorial Board

  • Page: 1169
  • First Published: 17 August 2016

Editor's Selection: This Month's Highlighted Articles

Brexit and diabetes

R. I. G. Holt, 
  • Page: 1171
  • First Published: 17 August 2016

Editorial

DAWN2 shines more light on the psychological burden of living with diabetes and on the correlates of quality psychological care

J. Speight, 
  • Pages: 1172-1173
  • First Published: 14 July 2016

Research Articles

Educational and Psychological Aspects

Correlates of psychological care strategies for people with diabetes in the second Diabetes Attitudes, Wishes and Needs (DAWN2™) study

R. I. G. Holt,  A. Nicolucci,  K. Kovacs Burns,  G. Lucisano,  S. E. Skovlund,  A. Forbes,  S. Kalra,  E. Menéndez Torre,  N. Munro,  M. Peyrot, 
  • Pages: 1174-1183
  • First Published: 04 March 2016
What's new?

  • This study examined barriers and facilitators for healthcare professionals in the provision of person-centred psychological care and self-management support for people with diabetes.
  • Psychological care was positively associated with beliefs that patients need help with emotional issues and that clinical success depends on doing so.
  • There were differences in psychological care between disciplines and countries.
  • The provision of psychological care improved with training received and desired, multidisciplinary team membership, and resources for psychological care.

Correlates of psychological outcomes among family members of people with diabetes in the second Diabetes Attitudes, Wishes and Needs (DAWN2™) study

K. Kovacs Burns,  R. I. G. Holt,  A. Nicolucci,  G. Lucisano,  S. E. Skovlund,  M. Comaschi,  M. Vallis,  M. Peyrot, 
  • Pages: 1184-1193
  • First Published: 18 April 2016
What's new?

  • DAWN2, conducted in 17 countries across four continents, is the first study to identify key sociodemographic, treatment-related, psychosocial and behavioural factors associated with psychological outcomes for adult family members of adults with diabetes.
  • Older age, not working because of diabetes, lower education or lower levels of education, use of injectable medicine by the person with diabetes, worry about hypoglycaemia, high perceived severity of diabetes and experience of discrimination on the part of the person with diabetes were associated with worse psychological outcomes among adult family members of people with diabetes.
  • Family arguments about diabetes management, frustration with not knowing how best to help, and greater responsibility for diabetes management were associated with worse psychological outcomes for family members of people with diabetes.
  • Knowing good ways to support, providing more support for diabetes and having access to more people to talk to about diabetes challenges were associated with better psychological outcomes.
  • The study extends earlier evidence from the DAWN2 study highlighting the psychosocial impact of diabetes on family members and identifies globally important factors for psychological well-being of family members of adults with diabetes which need to be considered in future efforts to improve diabetes care.

Correlates of psychological outcomes in people with diabetes: results from the second Diabetes Attitudes, Wishes and Needs (DAWN2™) study

A. Nicolucci,  K. Kovacs Burns,  R. I. G. Holt,  G. Lucisano,  S. E. Skovlund,  A. Kokoszka,  M. Massi Benedetti,  M. Peyrot, 
  • Pages: 1194-1203
  • First Published: 29 June 2016
What's new?

  • The results of this study provide a comprehensive assessment of the risk and protective factors for psychological outcomes among adults with diabetes on a global scale.
  • Modifiable risk/protective factors mediate the impact of demographic and clinical factors on psychological outcomes.
  • Accounting for individual-level risk and protective factors reduces between-country disparities in psychological outcomes, but results show that risk/protective factors operate differently in different countries.

Educational and Psychological Issues

A checklist that enhances the provision of education during insulin initiation simulation: a randomized controlled trial

C. G. Taylor Jr,  K. Bynoe,  A. Worme,  I. Hambleton,  A. Atherley,  A. Husbands,  N. Unwin, 
  • Pages: 1204-1210
  • First Published: 04 September 2015
What's new?

  • The provision of education by healthcare professionals to people with diabetes during insulin initiation is a potentially complex task given the extent of education required.
  • Checklists have proven to be beneficial in a number of areas within healthcare, but there are no published studies on their value during insulin initiation by doctors.
  • This paper presents a randomized control trial that shows significantly increased education imparted by doctors utilizing a checklist during simulated insulin initiation.
  • The checklist is applicable to insulin administration with a syringe or pen.

Systematic Review or Meta-analysis

High maternal iron status, dietary iron intake and iron supplement use in pregnancy and risk of gestational diabetes mellitus: a prospective study and systematic review

A. Z. Khambalia,  A. Aimone,  P. Nagubandi,  C. L. Roberts,  A. McElduff,  J. M. Morris,  K. L. Powell,  V. Tasevski,  N. Nassar, 
  • Pages: 1211-1221
  • First Published: 16 December 2015

Research Articles

Epidemiology

Open Access

Objectively measured sedentary time, physical activity and kidney function in people with recently diagnosed Type 2 diabetes: a prospective cohort analysis

V. YW. Guo,  S. Brage,  U. Ekelund,  S. J. Griffin,  R. K. Simmons,  on behalf of the ADDITION-Plus study team , 
  • Pages: 1222-1229
  • First Published: 18 August 2015
What's new?

  • Little is known about the prospective association between objectively measured physical activity and kidney function among individuals with Type 2 diabetes.
  • Over 4 years of follow-up, reductions in sedentary time and increases in total physical activity energy expenditure were associated with reductions in serum creatinine.
  • Reducing time spent sedentary and increasing overall physical activity may offer intervention opportunities to improve kidney function among individuals with diabetes.

Quality of care in patients with diabetic kidney disease in Asia: The Joint Asia Diabetes Evaluation (JADE) Registry

A. O. Luk,  X. Li,  Y. Zhang,  X. Guo,  W. Jia,  W. Li,  J. Weng,  W. Yang,  W. B. Chan,  R. Ozaki,  C. C. Tsang,  M. Mukhopadhyay,  A. K. Ojha,  E. G. Hong,  K. H. Yoon,  L. Sobrepena,  R. M. Toledo,  M. Duran,  W. Sheu,  T. Q. Do,  T. K. Nguyen,  R. C. Ma,  A. P. Kong,  C. C. Chow,  P. C. Tong,  W. Y. So,  J. C. Chan,  for the JADE Study Group , 
  • Pages: 1230-1239
  • First Published: 29 October 2015
What's new?

  • In this large multi-national Asia diabetes database, 15% of patients had diabetic kidney disease, over a quarter of whom had other concomitant micro- or macrovascular complications.
  • Despite their inherent high vascular risk, only one third of patients with diabetic kidney disease achieved pre-specified glycaemic and/or blood pressure targets and their use of organ-protective drugs such as renin–angiotensin system inhibitors and statins was suboptimal.
  • This article highlights a major treatment gap in Asian patients with diabetic kidney disease calling for greater quality improvement effort.

Smoking affects the oral glucose tolerance test profile and the relationship between glucose and HbA1c in gestational diabetes mellitus

A. Aulinas,  C. Colom,  A. García Patterson,  J. Ubeda,  M. A. María,  I. Orellana,  J. M. Adelantado,  A. de Leiva,  R. Corcoy, 
  • Pages: 1240-1244
  • First Published: 28 September 2015
What's new?

  • Women with gestational diabetes mellitus who smoke at the beginning of pregnancy had an oral glucose tolerance test consistent with accelerated glucose absorption and a disproportionately higher HbA1c.
  • In these women, 1 h plasma glucose and HbA1c overestimate glucose exposure.

Does First Nations ancestry modify the association between gestational diabetes and subsequent diabetes: a historical prospective cohort study among women in Manitoba, Canada

G. X. Shen,  L. A. Shafer,  P. J. Martens,  E. Sellers,  A. A. Torshizi,  S. Ludwig,  W. Phillips-Beck,  M. Heaman,  H. J. Prior,  J. McGavock,  M. Morris,  A. B. Dart,  R. Campbell,  H. J. Dean, 
  • Pages: 1245-1252
  • First Published: 11 September 2015
What's new?

  • This historical cohort study examined the impact of gestational diabetes after excluding pre-existing diabetes in mothers who delivered between 1981 and 2011 in Manitoba, Canada.
  • First Nations (FN) women had two times more gestational diabetes and were three times more likely to develop post-partum diabetes than non-FN women.
  • Post-partum diabetes in both FN and non-FN mothers was affected by gestational diabetes, lower family income and rural residence.
  • The relative risk of developing post-partum diabetes in non-FN women was higher than in FN women.
  • The findings suggest that reductions in gestational diabetes and socio-economic inequities are required to prevent post-partum diabetes in FN and non-FN women.

Pregnancy

Insulin pump use compared with intravenous insulin during labour and delivery: the INSPIRED observational cohort study

E. Drever,  G. Tomlinson,  A. D. Bai,  D. S. Feig, 
  • Pages: 1253-1259
  • First Published: 01 March 2016
What's new?

  • An increasing number of women are using continuous subcutaneous insulin infusion therapy (CSII) during their pregnancy, however, there are few data on the safety and efficacy of continuing this therapy during labour and delivery.
  • This is the first study to compare the use of CSII with an intravenous insulin infusion during labour and delivery.
  • This study demonstrates that the continuation of CSII in the labour and delivery period appears safe and efficacious, with similar glycaemic control in the CSII group compared with women using insulin infusion therapy during labour, with no serious adverse events. Moreover, women who choose to continue CSII during labour have better glucose control than those that choose to switch from CSII to intravenous insulin infusion, suggesting that it should be standard practice to allow women the option of continuing pump therapy during labour and delivery.

Complications

Cochlear, auditory brainstem responses in Type 1 diabetes: relationship with metabolic variables and diabetic complications

A. Lasagni,  P. Giordano,  M. Lacilla,  A. Raviolo,  M. Trento,  E. Camussi,  G. Grassi,  L. Charrier,  F. Cavallo,  R. Albera,  M. Porta,  M. M. Zanone, 
  • Pages: 1260-1267
  • First Published: 25 November 2015
What's new?

  • Auditory function involves the cochlea and neural transmission, making the ear a potential ‘window’ through which to evaluate microvascular and neurological abnormalities associated with chronic hyperglycaemia.
  • We tested the presence of auditory alterations in young adults with long-term Type 1 diabetes.
  • We detected a qualitative auditory dysfunction, reflecting cochlear dysfunction.
  • Otoacoustic emission alterations are associated with higher blood pressure, indicating a possible role for vascular mechanisms. A delay in acoustic nerve transmission and the presence of somatic or autonomic neuropathy are observed.
  • In young adults with Type 1 diabetes, abnormalities of auditory perception might reflect neuropathic and/or vascular alterations.

Functional hearing deficits in children with Type 1 diabetes

G. Rance,  D. Chisari,  N. Edvall,  F. Cameron, 
  • Pages: 1268-1274
  • First Published: 29 January 2016
What's new?

  • This study explores functional hearing deficits in children with Type 1 diabetes. As such, it differs from most work in this field, which has only considered the effect of diabetes on sound detection ability.
  • We demonstrate auditory pathway disorder in individuals with normal sound detection thresholds and consider the underlying mechanisms.
  • The findings highlight binaural processing deficits and their effect on speech processing in background noise.
  • Everyday listening ability is considered, as are potential developmental risks.

Association of hearing impairment with insulin resistance, β–cell dysfunction and impaired fasting glucose before onset of diabetes

M. Seo,  Y.-S. Lee,  S.-S. Moon, 
  • Pages: 1275-1282
  • First Published: 12 February 2016
What's new?

  • This is the first study to examine the association of insulin resistance, β–cell dysfunction and pre-diabetes with hearing impairment in a population before the onset of diabetes, using a representative sample of the general population

Treatment

Saxagliptin co-therapy in C-peptide negative Type 1 diabetes does not improve counter-regulatory responses to hypoglycaemia

P. S. George,  R. J. McCrimmon, 
  • Pages: 1283-1290
  • First Published: 07 December 2015
What's new?

  • This study tested the novel hypothesis that dipeptidyl peptidase-4 inhibitor co-therapy in Type 1 diabetes would act indirectly to improve symptom and hormonal responses to hypoglycaemia.
  • The hypothesis was rejected and no significant impact of dipeptidyl peptidase-4 inhibitor therapy was seen on measures of glucose variability, hypoglycaemia counter-regulation or glycaemic control.
  • These findings do not support the use of dipeptidyl peptidase-4 inhibitors in the management of C-peptide-negative Type 1 diabetes.

Care Delivery

Performance of three glomerular filtration rate estimation equations in a population of sub-Saharan Africans with Type 2 diabetes

D. D. Agoons,  E. V. Balti,  F. F. Kaze,  M. Azabji-Kenfack,  G. Ashuntantang,  A. P. Kengne,  E. Sobngwi,  J. C. Mbanya, 
  • Pages: 1291-1298
  • First Published: 20 October 2015
What's new?

  • Glomerular filtration rate (GFR) equations for estimating kidney function are routinely used in sub-Saharan Africa. There is, however, a paucity of data on the performance of these equations in patients with diabetes mellitus who are, for the most part, undiagnosed and unaware of their condition.
  • We investigated the performance of the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Cockcroft–Gault (CG) equations in patients with Type 2 diabetes.
  • Our results suggest that the lowest bias is observed with the MDRD formula compared with the CKD-EPI and CG equations. However, all three equations performed similarly in predicting altered kidney function based on low GFR.

Letters

Postprandial effects of the phosphodiesterase-5 inhibitor tadalafil in people with well-controlled Type 2 diabetes mellitus: a randomized controlled trial

L. Sjögren,  J. Olausson,  L. Strindberg,  R. Mobini,  P. Fogelstrand,  L. Mattsson Hultén,  P.-A. Jansson, 
  • Pages: 1299-1301
  • First Published: 20 October 2015

The impact of smoking on the effect of the rs4972593 genetic variant on end-stage renal disease

M. Feodoroff,  V. Harjutsalo,  C. Forsblom,  N. Sandholm,  P.-H. Groop, on behalf of the FinnDiane Study Group , 
  • Pages: 1301-1303
  • First Published: 04 November 2015

Abstracts of the Online Only Case Reports

Abstracts of the Online Only Case Reports

  • Page: 1304
  • First Published: 17 August 2016

Case Reports

Use of continuous glucose monitoring in patients with diabetes on peritoneal dialysis: poor correlation with HbA1c and high incidence of hypoglycaemia

E. Oei,  N. Samad,  A. Visser,  T. A. Chowdhury,  S. L. Fan, 
  • Pages: e17-e20
  • First Published: 15 October 2015
What's new?

  • Managing glucose in patients with diabetes on peritoneal dialysis is challenging.
  • We present three patients with very similar HbA1c levels, but with significantly different glucose profiles.
  • HbA1c assessment is insufficient to safely manage glucose in patients with diabetes on peritoneal dialysis.
  • Intermittent continuous glucose monitoring may be useful to safely manage glucose in such patients, and avoid hypoglycaemia.

Open Access

tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy

T. W. Yew,  L. McCreight,  K. Colclough,  S. Ellard,  E. R. Pearson, 
  • Pages: e21-e25
  • First Published: 03 November 2015
What's new?

  • This report describes the fourth family reported to have diabetes mellitus caused by a mutation in the TRMT10A gene.
  • In contrast to the previous families, the diabetes mellitus in the patients we describe was diagnosed after 20 years of age, and at diagnosis they had only mild learning disability and epilepsy with minimal other clinical features.
  • TRMT10A sequencing should be considered in children or adults with young-onset diabetes who have a history of intellectual disability, microcephaly and epilepsy.
  • A targeted panel may be useful to identify previously unsuspected monogenic diabetes among individuals with young-onset diabetes.