Although not a pathbreaking work, the paper handles a complex problemthat has not been studied in significant detail. Thus it adds valuable information to the pool of knowledge in the area.

The authors, using experience from a single centre, derive a point based “risk” score, which can aid in determining an individual's risk for a major complication following percutaneous renalbiopsy of the native kidney.

Contrast-induced nephropathy (CIN) is a common and serious side effect in patients undergoing cardioangiography or radiological procedures. N-acetylcysteine is an option in preventing CIN.

This manuscript describes practical issues in using eculizumab for children with atypical haemolytic uraemic syndrome (aHUS). Since clinical information on the use of eculizumab for children with aHUS are limited, and the rationale for its long-term use has yet to be established, this study would provide helpful information for clinicians.

Although not something that changes practice, it does examine an aspect that is not often studied. It does contribute to what clinician see every day, depressed patients fare worse.

This study shows post dialysis fatigue is associated with patients' age and ADL, and not with dialytic variables.

Hypothyroidism is associated with increased all-cause mortality in chronic HD patients in Taiwan. Thyroxin replacement therapy lowers the risk of mortality in a time-varying Cox proportional hazard regression analysis.

A single-centre study examining the spectrum of histopathological diagnoses in patients with nephrotic syndrome and nephrotic range proteinuria over a 30-year period.

An interesting manuscript which investigates whether fluorofenidone (one of the pyridine agents) could ameliorate kidney fibrosis process in UUO model by regulating the interaction of NLRP3 inflammasome-assembly and the inhibition of IL-1B production.

The manuscript highlights important issues relating to kidney transplant outcome during the young adolescent and the early adulthood period. Accepting the limitations of the study which uses registry acquired data, the manuscript demonstrates significant graft loss throughout the time period relating to age; however, transition from paediatric care to young adulthood was not a specific risk factor.