Haemophilia: Vol 20, No 4

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Haemophilia: Volume 20, Issue 4

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Editorial

Does the orphan medicinal product regulation assist or hinder access to innovative haemophilia treatment in Europe ?

Review Articles

The burden of bleeding in haemophilia: is one bleed too many?

Use of recombinant activated factor VII in patients with Glanzmann's thrombasthenia: a review of the literature

Original Articles

Clinical haemophilia

Cardiovascular comorbidities are increased in US patients with haemophilia A: a retrospective database analysis

Physical and mental quality of life in adult patients with haemophilia in Belgium: the impact of financial issues

Predictive immunogenicity of Refacto® AF

A longitudinal study of family structure in Swedish persons with haemophilia

The demographics of the United States haemophilia treatment centre social workers: the results of a national survey

Better adherence to prescribed treatment regimen is related to less chronic pain among adolescents and young adults with moderate or severe haemophilia

Coping in adult patients with severe haemophilia

A haemophilia disease management programme targeting cost and utilization of specialty pharmaceuticals

Assessment of the impact of treatment on quality of life of patients with haemophilia A at different ages: insights from two clinical trials on turoctocog alfa

Trends in the epidemiology, diagnosed age and mortality rate of haemophiliacs in Taiwan: a population-based study, 1997–2009

Understanding the experience of caring for children with haemophilia: cross-sectional study of caregivers in the United States

Diagnosis and management challenges in patients with mild haemophilia A and discrepant FVIII measurements

von Willebrand disease

Diagnosis of inherited von Willebrand disease: comparison of two methodologies and analysis of the discrepancies

Rare bleeding disorder

Congenital factor XIII deficiency in Pakistan: characterization of seven families and identification of four novel mutations

Rare coagulation factor deficiencies: a countrywide screening data from India

Muskuloskeletal

Is joint effusion on MRI specific for haemophilia?

Major surgery in severe haemophilia A with inhibitors using a recombinant factor VIIa and activated prothrombin complex concentrate hybrid regimen

Laboratory science

Evaluation of the activated partial thromboplastin time assay for clinical monitoring of PEGylated recombinant factor VIII (BAY 94-9027) for haemophilia A

Clinical haemophilia

Therapeutic management and costs of severe haemophilia A patients with inhibitors in Italy

First analysis of 10-year trends in national factor concentrates usage in haemophilia: data from CHARMS, the Canadian Hemophilia Assessment and Resource Management System

Impact of health instructions on improving knowledge and practices of haemophilia A adolescents: a single centre experience

Reliability and validity of a novel Haemophilia-specific Self-Efficacy Scale

When is enough … enough? Developing consensus of definition of failure of immune tolerance induction in patients with haemophilia and inhibitors

Prospective observational cohort studies for studying rare diseases: the European PedNet Haemophilia Registry

Haemophilia Experiences, Results and Opportunities (HERO) Study: Influence of haemophilia on interpersonal relationships as reported by adults with haemophilia and parents of children with haemophilia

Assessing patients' and caregivers' perspectives on stability of factor VIII products for haemophilia A: a web-based study in the United States and Canada

von Willebrand disease

Evaluation of a rapid von Willebrand Factor Activity Latex Immuno Assay for monitoring of patients with von Willebrand disease (VWD) receiving DDAVP® or VWF replacement therapy

Germline de novo mutations and linkage markers vs. DNA sequencing for carrier detection in von Willebrand disease

Laboratory science

Asp68His mutation in the A1 domain of human factor V causes impaired secretion and ineffective translocation

Validation of the manufacturing process used to produce long-acting recombinant factor IX Fc fusion protein

Online Letters

Percutaneous transluminal angioplasty and stent implantation for aortic coarctation in haemophilia A patient with high-titre factor VIII inhibitors

Oral health status among 6- to 12-year-old haemophilic children–An educational intervention study

Discrepancy in von Willebrand factor activity determined by ristocetin cofactor and immunotubidometric assays

Use of factor VIII after inhibitor clearance in patients with moderate haemophilia A: a case series

A Haut-Doubs FVII variant depending on species-derived-thromboplastin reagent (F7:p.Arg337His)

FXI concentrate use and risk of thrombosis

Statistical modelling issues in the RODIN study

Traumatic hyphaema in a patient with severe haemophilia B

Acquired thrombin and FV inhibitors upon aortic bioprosthetic valve replacement

Life expectancy of Korean haemophiliacs, 1991–2012

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Predictive immunogenicity of Refacto^® AF

Evaluation of a rapid von Willebrand Factor Activity Latex Immuno Assay for monitoring of patients with von Willebrand disease (VWD) receiving DDAVP^® or VWF replacement therapy