The cover image is based on the Review Article Clonal mast cell disorders and hereditary α-tryptasemia as risk factors for anaphylaxis by Mark Kačar et al., https://doi.org/10.1111/cea.14264.

Non-clonal mast cell disease, hereditary alpha-tryptasemia, and anaphylaxis. Hereditary alpha-tryptasemia (HαT) is strongly associated with clonal mast cell disease (cMCD). Either of those conditions alone is a predisposing factor for severe IgE-dependent and IgE-independent anaphylaxis however, the presence of HαT in patients with cMCD serves to further increase the severity of anaphylactic reactions.

Five different patterns of cough trajectories during early childhood have been highlighted. Recurrent cough without a cold, with night cough and triggers should lead to allergy and asthma assessment. Growing up on a farm seems to have a protective effect on acute transient cough and early persistent cough.

The integrated and continuous tight junctions (TJs) play a crucial role in maintaining normal epithelial barrier function of nasal mucosa. This could effectively prevent the invasion of foreign particles. The pathogenesis and development of chronic rhinosinusitis (CRS) is associated with failure of barrier function in nasal mucosa, especially for the nasal polyps of patients with eosinophilic CRSwNP (Eos CRSwNP). In the meantime, expression of HDACs is increased in these patients and inhibition of HDACs activity may reconstitute the nasal epithelial barrier integrity in Eos CRSwNP.