• Issue

    Alimentary Pharmacology & Therapeutics: Volume 55, Issue 12

    1475-1591
    June 2022

ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 1475-1477
  • First Published: 24 May 2022

SYSTEMATIC REVIEW

Open Access

Systematic review—pancreatic involvement in inflammatory bowel disease

  • Pages: 1478-1491
  • First Published: 03 May 2022
Systematic review—pancreatic involvement in inflammatory bowel disease

Systematic review. Pancreatic involvement in inflammatory bowel disease (IBD). The wide spectrum of pancreatic involvement in patients with IBD may represent a challenge. From the 124 studies analyzed, acute pancreatitis (AP) is the most frequent pancreatic manifestation in IBD; the majority of AP cases in IBD are due to gallstones and drugs, but cases of idiopathic AP are increasingly reported. Autoimmune pancreatisis is a rare disease, but a strong association with IBD has been demonstrated, especially for type 2 and ulcerative colitis.

CLINICAL TRIALS

Open Access

Randomised clinical trial: individual versus group hypnotherapy for irritable bowel syndrome

  • Pages: 1501-1511
  • First Published: 03 May 2022
Randomised clinical trial: individual versus group hypnotherapy for irritable bowel syndrome

Significant improvements regarding IBS symptoms were seen for patients receiving individual or group hypnotherapy, with no differences between the groups.

Open Access

Reaching people receiving opioid agonist therapy at community pharmacies with hepatitis C virus: an international randomised controlled trial

  • Pages: 1512-1523
  • First Published: 10 May 2022
Reaching people receiving opioid agonist therapy at community pharmacies with hepatitis C virus: an international randomised controlled trial

Relative to conventional care, opioid agonist therapy clients offered point-of-care hepatitis c virus RNA testing and treatment with DAAs at their community pharmacy had higher odds of being tested, starting treatment, and obtaining a cure.

The efficacy and safety of keverprazan, a novel potassium-competitive acid blocker, in treating erosive oesophagitis: a phase III, randomised, double-blind multicentre study

  • Pages: 1524-1533
  • First Published: 03 May 2022
The efficacy and safety of keverprazan, a novel potassium-competitive acid blocker, in treating erosive oesophagitis: a phase III, randomised, double-blind multicentre study

The current multicentre study demonstrated the non-inferior efficacy of keverprazan to lansoprazole in treating erosive oesophagitis. The incidences of drug-related adverse events were comparable between keverprazan and lansoprazole.

IMPLICATIONS OF T-CELL RESPONSES IN CHRONIC HEPATITIS B

Open Access

Model to predict on-treatment restoration of functional HBV-specific CD8+ cell response foresees off-treatment HBV control in eAg-negative chronic hepatitis B

  • Pages: 1545-1559
  • First Published: 27 February 2022
Model to predict on-treatment restoration of functional HBV-specific CD8+ cell response foresees off-treatment HBV control in eAg-negative chronic hepatitis B

Based on therapy starting age and duration, HBsAg level and infection length, a high likelihood of a functional HBV specific CD8+ cell response during nucleos(t)ide analogue treatment foresees HBV control after treatment discontinuation.

DEFINING NORMAL POUCH FUNCTION IN ILEAL POUCH-ANAL ANASTOMOSIS

Defining normal pouch function in patients with ileal pouch-anal anastomosis: a pilot study

  • Pages: 1560-1568
  • First Published: 11 March 2022
Defining normal pouch function in patients with ileal pouch-anal anastomosis: a pilot study

Anatomic axial T2-weighted MR images without (A) and with (B) fat saturation in an asymptomatic patient with IPAA show an intersphincteric perianal fistula (arrow) with internal opening below the level of the anastomosis.