Cancer Science: Vol 102, No 4

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The Official Journal of the Japanese Cancer Association

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Cancer Science: Volume 102, Issue 4

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COVER IMAGE

Analysis of HLA-A24-restricted peptides of carcinoembryonic antigen using a novel structure-based peptide-HLA docking algorithm

In This Issue

In This Issue

REVIEW ARTICLES

Secondary mutations of BRCA1/2 and drug resistance

Double control systems for human T-cell leukemia virus type 1 by innate and acquired immunity

DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis

ORIGINAL ARTICLES

BASIC AND CLINICAL IMMUNOLOGY

Identification of HLA-A*2402-restricted epitope peptide derived from ERas oncogene expressed in human scirrhous gastric cancer

Analysis of HLA-A24-restricted peptides of carcinoembryonic antigen using a novel structure-based peptide-HLA docking algorithm

A novel tumor-associated antigen, cell division cycle 45-like can induce cytotoxic T-lymphocytes reactive to tumor cells

Normalization of T cell receptor repertoire diversity in patients with advanced colorectal cancer who responded to chemotherapy

CARCINOGENESIS

Activation of epidermal growth factor receptor signaling by the prostaglandin E2 receptor EP4 pathway during gastric tumorigenesis

Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice

Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells

Decrease of hepatic stellate cells in rats with enhanced sensitivity to clofibrate-induced hepatocarcinogenesis

Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1

CELL, MOLECULAR, AND STEM CELL BIOLOGY

Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress

Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells

Evaluation of Aurora kinase inhibition as a new therapeutic strategy in anaplastic and poorly differentiated follicular thyroid cancer

Inhibition of tumor growth and sensitization to chemotherapy by RNA interference targeting interleukin-6 in the androgen-independent human prostate cancer PC3 model

Loss of RUNX3 expression by histone deacetylation is associated with biliary tract carcinogenesis

Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency

X-ray irradiation and Rho-kinase inhibitor additively induce invasiveness of the cells of the pancreatic cancer line, MIAPaCa-2, which exhibits mesenchymal and amoeboid motility

Contribution of autophagic cell death to p53-dependent cell death in human glioblastoma cell line SF126

Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy

Matrix metalloproteinase-9 cooperates with transcription factor Snail to induce epithelial–mesenchymal transition

SPA-1 controls the invasion and metastasis of human prostate cancer

Heterotrimeric stimulatory GTP-binding proteins inhibit cisplatin-induced apoptosis by increasing X-linked inhibitor of apoptosis protein expression in cervical cancer cells

CLINICAL RESEARCH

Phase I study of intravenous ASA404 (vadimezan) administered in combination with paclitaxel and carboplatin in Japanese patients with non-small cell lung cancer

Cancer detection using infrared hyperspectral imaging

Ki67 index changes, pathological response and clinical benefits in primary breast cancer patients treated with 24 weeks of aromatase inhibition

Reduced serum vascular endothelial growth factor receptor-2 (sVEGFR-2) and sVEGFR-1 levels in gastric cancer patients

DRUG DISCOVERY AND DELIVERY

Catalase suppression-mediated H2O2 accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis

EPIDEMIOLOGY AND PREVENTION

Prevalence and type distribution of human papillomavirus in healthy Japanese women aged 20 to 25 years old enrolled in a clinical study

GENETICS, GENOMICS AND PROTEOMICS

Microarray analysis identifies versican and CD9 as potent prognostic markers in gastric gastrointestinal stromal tumors

INFLAMMATION AND VIROLOGY

c-Maf suppresses human T-cell leukemia virus type 1 Tax by competing for CREB-binding protein

PATHOLOGY

Persistent Krüppel-like factor 4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma

Expression of aldehyde dehydrogenase 1 (ALDH1) in endometrioid adenocarcinoma and its clinical implications

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Activation of epidermal growth factor receptor signaling by the prostaglandin E₂ receptor EP4 pathway during gastric tumorigenesis

Catalase suppression-mediated H₂O₂ accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis