• Issue

    Cancer Science: Volume 100, Issue 7

    1145-1358
    July 2009
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REVIEW ARTICLES

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Fragile gene product, Fhit, in oxidative and replicative stress responses

Hiroshi Okumura,  Hideshi Ishii,  Flavia Pichiorri,  Carlo M. Croce,  Masaki Mori,  Kay Huebner, 
  • Pages: 1145-1150
  • First Published: 10 June 2009
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Hereditary diffuse gastric cancer: A manifestation of lost cell polarity

Bostjan Humar,  Parry Guilford, 
  • Pages: 1151-1157
  • First Published: 10 June 2009
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Chromosome segregation machinery and cancer

Kozo Tanaka,  Toru Hirota, 
  • Pages: 1158-1165
  • First Published: 10 June 2009
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Cancer stem cells and their niche

Hiroko Iwasaki,  Toshio Suda, 
  • Pages: 1166-1172
  • First Published: 10 June 2009
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Reviewing the current classification of inhibitor of growth family proteins

Motoko Unoki,  Kensuke Kumamoto,  Seiichi Takenoshita,  Curtis C. Harris, 
  • Pages: 1173-1179
  • First Published: 10 June 2009

ORIGINAL ARTICLES

CARCINOGENESIS

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Gastric carcinogenesis by N-Methyl-N-Nitrosourea is enhanced in db/db diabetic mice

Nao Yoshizawa,  Hirokazu Yamaguchi,  Masami Yamamoto,  Nobuyuki Shimizu,  Chie Furihata,  Masae Tatematsu,  Yasuyuki Seto,  Michio Kaminishi, 
  • Pages: 1180-1185
  • First Published: 10 June 2009
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Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus

Seiji Baba,  Yasuhiro Yamada,  Yuichiro Hatano,  Yasuo Miyazaki,  Hideki Mori,  Toshiyuki Shibata,  Akira Hara, 
  • Pages: 1186-1191
  • First Published: 10 June 2009
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Chronic nonsteroidal anti-inflammatory drug (NSAID) use suppresses multiple CpG islands hyper methylation (CIHM) of tumor suppressor genes in the human gastric mucosa

Tomomitsu Tahara,  Tomoyuki Shibata,  Hiromi Yamashita,  Masakatsu Nakamura,  Daisuke Yoshioka,  Masaaki Okubo,  Ichiro Hirata,  Tomiyasu Arisawa, 
  • Pages: 1192-1197
  • First Published: 10 June 2009

TUMOR BIOLOGY AND PATHOLOGY

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Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma

Ying Qiu,  Eiichi Morii,  Yasuhiko Tomita,  Binglin Zhang,  Akihide Matsumura,  Masanori Kitaichi,  Meinoshin Okumura,  Katsuyuki Aozasa, 
  • Pages: 1198-1209
  • First Published: 10 June 2009
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Angiogenic growth factors in tissue homogenates of HNSCC: expression pattern, prognostic relevance, and interrelationships

Michael Montag,  Gerhard Dyckhoff,  Jennifer Lohr,  Burkhard M. Helmke,  Eva Herrmann,  Peter K. Plinkert,  Christel Herold-Mende, 
  • Pages: 1210-1218
  • First Published: 10 June 2009
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Haploinsufficiency and acquired loss of Bcl11b and H2AX induces blast crisis of chronic myelogenous leukemia in a transgenic mouse model

Akiko Nagamachi,  Norimasa Yamasaki,  Kazuko Miyazaki,  Hideaki Oda,  Masaki Miyazaki,  Zen-ichiro Honda,  Ryo Kominami,  Toshiya Inaba,  Hiroaki Honda, 
  • Pages: 1219-1226
  • First Published: 10 June 2009
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Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma

Kazuhito Morioka,  Chizu Tanikawa,  Kensuke Ochi,  Yataro Daigo,  Toyomasa Katagiri,  Hirotaka Kawano,  Hiroshi Kawaguchi,  Akira Myoui,  Hideki Yoshikawa,  Norifumi Naka,  Nobuto Araki,  Ikuo Kudawara,  Makoto Ieguchi,  Kozo Nakamura,  Yusuke Nakamura,  Koichi Matsuda, 
  • Pages: 1227-1233
  • First Published: 10 June 2009
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Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma

Yang Li,  Weiqi Tan,  Thomas W.L. Neo,  Myat O. Aung,  Shanthi Wasser,  Seng G. Lim,  Theresa M.C. Tan, 
  • Pages: 1234-1242
  • First Published: 10 June 2009
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HER2 overexpression correlates with survival after curative resection of pancreatic cancer

Masahiro Komoto,  Bunzo Nakata,  Ryosuke Amano,  Nobuya Yamada,  Masakazu Yashiro,  Masaichi Ohira,  Kenichi Wakasa,  Kosei Hirakawa, 
  • Pages: 1243-1247
  • First Published: 10 June 2009
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Syndecan-1, a new target molecule involved in progression of androgen-independent prostate cancer

Keiji Shimada,  Mitsutoshi Nakamura,  Marco A. De Velasco,  Motoyoshi Tanaka,  Yukiteru Ouji,  Noboru Konishi, 
  • Pages: 1248-1254
  • First Published: 10 June 2009
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Serum soluble interleukin-2 receptor level and immunophenotype are prognostic factors for patients with diffuse large B-cell lymphoma

Toshiaki Morito,  Megumu Fujihara,  Hideki Asaoku,  Akira Tari,  Yasuharu Sato,  Kouichi Ichimura,  Takehiro Tanaka,  Katsuyoshi Takata,  Maiko Tamura,  Tadashi Yoshino, 
  • Pages: 1255-1260
  • First Published: 10 June 2009
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Very low prevalence of XPD K751Q polymorphism and its association with XPD expression and outcomes of FOLFOX-4 treatment in Asian patients with colorectal carcinoma

Jiun-I. Lai,  Cheng-Hwai Tzeng,  Po-Min Chen,  Jen-Kou Lin,  Tzu-Chen Lin,  Wei-Shone Chen,  Jeng-Kae Jiang,  Huann-Sheng Wang,  Wei-Shu Wang, 
  • Pages: 1261-1266
  • First Published: 10 June 2009
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Combination of peritumoral mast cells and T-regulatory cells predicts prognosis of hepatocellular carcinoma

Min-Jie Ju,  Shuang-Jian Qiu,  Qiang Gao,  Jia Fan,  Ming-Yan Cai,  Yi-Wei Li,  Zhao-You Tang, 
  • Pages: 1267-1274
  • First Published: 10 June 2009

MOLECULAR BIOLOGY AND GENETICS

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Level of reactive oxygen species induced by p21WAF(1)/CIP(1) is critical for the determination of cell fate

Takafumi Inoue,  Kiyoko Kato,  Hidenori Kato,  Kazuo Asanoma,  Ayumi Kuboyama,  Yousuke Ueoka,  Shin-ichiro Yamaguchi,  Tatsuhiro Ohgami,  Norio Wake, 
  • Pages: 1275-1283
  • First Published: 10 June 2009
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High throughput analysis of proteins associating with a proinvasive MT1-MMP in human malignant melanoma A375 cells

Taizo Tomari,  Naohiko Koshikawa,  Takayuki Uematsu,  Takashi Shinkawa,  Daisuke Hoshino,  Nagayasu Egawa,  Toshiaki Isobe,  Motoharu Seiki, 
  • Pages: 1284-1290
  • First Published: 10 June 2009
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Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2

Chihiro Ohtsubo,  Daisuke Shiokawa,  Masami Kodama,  Christian Gaiddon,  Hitoshi Nakagama,  Aart G. Jochemsen,  Yoichi Taya,  Koji Okamoto, 
  • Pages: 1291-1299
  • First Published: 10 June 2009

EPIDEMIOLOGY AND PREVENTION

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Constitutive telomere length and gastric cancer risk: Case-control analysis in Chinese Han population

Xiaonan Liu,  Guoqiang Bao,  Tingting Huo,  Zizhong Wang,  Xianli He,  Guanglong Dong, 
  • Pages: 1300-1305
  • First Published: 10 June 2009
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Regional differences in population-based cancer survival between six prefectures in Japan: Application of relative survival models with funnel plots

Yuri Ito,  Akiko Ioka,  Hideaki Tsukuma,  Wakiko Ajiki,  Tomoyuki Sugimoto,  Bernard Rachet,  Michel P. Coleman, 
  • Pages: 1306-1311
  • First Published: 10 June 2009

IMMUNOLOGY AND VIROLOGY

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Human papillomavirus infections among Japanese women: age-related prevalence and type-specific risk for cervical cancer

Mamiko Onuki,  Koji Matsumoto,  Toyomi Satoh,  Akinori Oki,  Satoshi Okada,  Takeo Minaguchi,  Hiroyuki Ochi,  Sari Nakao,  Katsumi Someya,  Naoki Yamada,  Hiromi Hamada,  Hiroyuki Yoshikawa, 
  • Pages: 1312-1316
  • First Published: 10 June 2009
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Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+ T cells with tumor regression

Naoko Imai,  Hiroaki Ikeda,  Isao Tawara,  Linan Wang,  Lijie Wang,  Hiroyoshi Nishikawa,  Takuma Kato,  Hiroshi Shiku, 
  • Pages: 1317-1325
  • First Published: 10 June 2009
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Malignant mesothelioma-associated antigens recognized by tumor-infiltrating B cells and the clinical significance of the antibody titers

Yoshiki Shigematsu,  Takeshi Hanagiri,  Koji Kuroda,  Tetsuro Baba,  Makiko Mizukami,  Yoshinobu Ichiki,  Manabu Yasuda,  Mitsuhiro Takenoyama,  Kenji Sugio,  Kosei Yasumoto, 
  • Pages: 1326-1334
  • First Published: 10 June 2009

EXPERIMENTAL THERAPEUTICS AND CLINICAL MEDICINE

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Activity of triptolide against human mast cells harboring the kinase domain mutant KIT

Yanli Jin,  Qi Chen,  Xianping Shi,  Zhongzheng Lu,  Chao Cheng,  Yingrong Lai,  Qin Zheng,  Jingxuan Pan, 
  • Pages: 1335-1343
  • First Published: 10 June 2009
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Phase I/II and pharmacokinetic study of cladribine with 2-h infusion in Japanese patients with relapsed indolent B-cell lymphoma mostly pretreated with rituximab

Kensei Tobinai,  Takashi Watanabe,  Kazuki Tanimoto,  Dai Maruyama,  Masanobu Nakata,  Kuniaki Itoh,  Yasuo Morishima,  Michinori Ogura,  Noriko Usui,  Masaharu Kasai,  Takashi Terauchi,  Shigeru Nawano,  Masaki Matsusako,  Yoshihiro Matsuno,  Shigeo Nakamura,  Shigeo Mori,  Yasuo Ohashi, 
  • Pages: 1344-1350
  • First Published: 10 June 2009
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Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models

Yuko Kishi,  Keiji Kuba,  Takahiro Nakamura,  Jinhua Wen,  Yoshinori Suzuki,  Shinya Mizuno,  Toshihiro Nukiwa,  Kunio Matsumoto,  Toshikazu Nakamura, 
  • Pages: 1351-1358
  • First Published: 10 June 2009