CTI Special Feature on Unconventional immunity: the role of γδT cells in host defense and disease

Special Feature Coordinators: Martin Davey and Emily Eriksson

γδ T cells have been preserved alongside αβ T cells and B cells for ~500 million years of vertebrate evolution. γδ T cells are increasingly recognised as having important roles in immune responses to both microbial and non-microbial challenges in mice and humans. In this Special Feature of Clinical & Translational Immunology, we highlight the role of γδ T cells in infectious disease, cancer, transplantation and the lasting contributions of a pioneer of γδ T cell research.

Image: Unconventional immunity provided by γδ T cells. Scheme depicting the multifaceted interactions of γδ T cells in infectious disease, cancer and transplantation. Artwork was created from modified material supplied by Servier Medical Art, under a Creative Commons Attribution 3.0 Unported License.