CTI Special Feature on Innate Immune Responses and Vaccine Design

CTI Special Feature on Innate Immune Responses and Vaccine Design

Special Feature Coordinators: Christopher Sundling and Kerrie Sandgren.

The challenge of developing next generation vaccines against some of the most burdensome diseases—both infectious and inflammatory, will require an injection of basic knowledge as well as scientific innovation. As highlighted in this collection of expert reviews, the innate immune response is a critical stepping-stone between vaccination and the development of effective adaptive immunity, triggering and shaping the ensuing cellular and humoral responses that will ultimately control the disease. An enhanced understanding of how innate immunity develops in different disease states will help inform the design and formulation of new vaccine components. Conversely, an increased understanding of the mechanism of action of novel adjuvants will aid in their rational selection for different diseases and delivery platforms. In this Special Feature of Clinical and Translational Immunology, we present a number of papers that jointly highlight the interplay between innate immune responses and the resulting functional vaccine responses.

EDITORIAL

CTI special feature on innate immune responses and vaccine design
Christopher Sundling and Kerrie Sandgren
Clinical & Translational Immunology (2016) 5, e96; doi:10.1038/cti.2016.50 Published online 12 August 2016
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REVIEWS

The cell surface environment for pathogen recognition and entry
Jennifer L Stow and Nicholas D Condon
Clinical & Translational Immunology (2016) 5, e71; doi:10.1038/cti.2016.15 Published online 15 April 2016
Abstract | Full Text | PDF

Understanding natural herpes simplex virus immunity to inform next-generation vaccine design
Kerrie J Sandgren, Kirstie Bertram and Anthony L Cunningham
Clinical & Translational Immunology (2016) 5, e94; doi:10.1038/cti.2016.44 Published online 29 July 2016
Abstract | Full Text | PDF

Toll-like receptors: the swiss army knife of immunity and vaccine development
Jennifer K Dowling and Ashley Mansell
Clinical & Translational Immunology (2016) 5, e85; doi:10.1038/cti.2016.22 Published online 20 May 2016
Abstract | Full Text | PDF

Targeting dendritic cells: a promising strategy to improve vaccine effectiveness
Christophe Macri, Claire Dumont, Angus PR Johnston and Justine D Mintern
Clinical & Translational Immunology (2016) 5, e66; doi:10.1038/cti.2016.6 Published online 18 March 2016
Abstract | Full Text | PDF

Local innate immune responses in the vaccine adjuvant-injected muscle
Frank Liang and Karin Loré
Clinical & Translational Immunology (2016) 5, e74; doi:10.1038/cti.2016.19 Published online 29 April 2016
Abstract | Full Text | PDF