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Figure 1
Domain architecture and structural features of SARS-CoV-2 NSP13. (a) Schematic representation of the domain organization of NSP13, consisting of five domains: the zinc-binding domain (ZBD, green), stalk domain (S, wheat), 1B domain (grey), RecA1 domain (orange) and RecA2 domain (blue). The 1B domain and RecA1 domain are connected by an unstructured linker (dark grey). The conserved helicase motifs (I–VI) within the RecA1 and RecA2 domains are displayed with their respective residue ranges and sequences within NSP13. (b) Surface representation of the three-dimensional structure of NSP13, with domains coloured as in (a). Key structural features include the nucleotide-binding site, formed between the RecA1 and RecA2 domains, and the RNA tunnel, formed by all domains except the ZBD. The structure is presented in two orientations rotated horizontally by 100°.

Journal logo STRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 81| Part 8| August 2025| Pages 338-347
https://doi.org/10.1107/S2053230X25005266
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