Pediatric Transplantation

After review of suspected EBV-driven Post-Transplant Lymphoproliferative Disorders (PTLD), according to the WHO 2022 criteria, the incidence was 11.7% in our cohort. Non-destructive PTLD was the most common subtype. Spatial/temporal heterogeneity required multiple biopsies. mTOR inhibitors were well tolerated. A diagnostic algorithm was developed to enhance the management of PTLD.

Pretransplant frailty in children is associated with worse post-LT outcomes. Multicenter study included patients who had frailty assessment and then underwent liver transplant. Clinical outcomes were collected up to 1 year post LT. 28 pediatric LT recipients were included, and 15 participants met criteria for frailty. Higher pre-transplant frailty scores were also significantly associated with an increased number of readmissions after transplantation (p = 0.034). Pediatric frailty is associated with increased frequency of hospitalization in the first year after pediatric liver transplantation. These data support the concept that frail children should be identified and targeted for prehabilitation prior to liver transplant.

Survival after allogeneic hematopoietic stem cell transplants (aHSCTs) in the state of Florida since the creation of a state pediatric HSCT consortium has improved. This is significant because it demonstrates that small-sized pediatric HSCT centers can work together in a consortium to improve outcomes similar to larger centers.

We present the lower urinary tract management of our patients with bilateral renal agenesis. As these patients do not have bladders, they are managed via cutaneous ureterostomy concurrently with kidney transplantation.

This retrospective quality assurance study aimed to investigate the incidence and management of pediatric PTLD among all 457 pediatric solid organ transplant recipients In Norway since 1995. We found a PTLD incidence rate of 4.8% (kidney 4.4%, liver 5.7%, and heart 4.2%) and a fatality rate of 23%.

High expression levels of Kasai intraoperative serum MMP-7 and ALP increase the risk of postoperative liver transplantation in BA pediatric patients. The combined detection of the two can assist in predicting the postoperative liver transplantation status in BA pediatric patients.

Semilunar valves from the hearts of patients receiving a retransplant can be used for partial heart transplants.