Acute polymyositis after donor lymphocyte infusion

Peng-Chan Lin

Department of Medical Oncology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan

Search for more papers by this author

Liang-Tsai Hsiao,

Liang-Tsai Hsiao

Department of Medical Oncology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan

Search for more papers by this author

Po-Min Chen,

Po-Min Chen

Department of Medical Oncology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan

Search for more papers by this author

Peng-Chan Lin,

Peng-Chan Lin

Department of Medical Oncology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan

Search for more papers by this author

Liang-Tsai Hsiao,

Liang-Tsai Hsiao

Department of Medical Oncology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan

Search for more papers by this author

Po-Min Chen,

Po-Min Chen

Department of Medical Oncology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan

Search for more papers by this author

First published: 11 January 2005

https://doi.org/10.1111/j.1600-0609.2004.00344.x

Citations: 12

Po-Min Chen MD PhD, Department of Medical Oncology, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, Taipei 11217, Taiwan
Tel: +886 2 287 57528
Fax: +886 2 287 32184
e-mail: [email protected]

Share a link

Email
Facebook
x
LinkedIn
Reddit
Wechat
Bluesky

Abstract

Abstract: Polymyositis usually occurred along with other manifestations of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) had been reported. However, polymyositis with a sole manifestation of acute GVHD following donor lymphocyte infusion (DLI) is rare. We reported a 45-yr-old man of acute lymphoid leukemia post-allogeneic HSCT 6 months developed acute polymyositis after DLI. He did not develop any symptoms, signs of acute or chronic GVHD following allogeneic HSCT, despite withdraw of immuosuppresive agents, cyclosporin A (CsA). As the DNA-STR of bone marrow analysis showed mixed chimerism, he received the DLI for remission on May 16, 2002. Acute polymyositis developed following DLI 22 d later. The clinical presentation of polymyositis is compatible with a manifestation of acute GVHD following DLI. It also responds to the treatment of steroid and CsA.

References

1 Shulman HM, Sullivan KM, Weiden PL, et al. Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med 1980; 69: 204–217.
10.1016/0002-9343(80)90380-0
CAS PubMed Web of Science® Google Scholar
2 Parker P, Chao NJ, Ben Ezra J, et al. Polymyositis as a manifestation of chronic graft-versus-host disease. Medicine (Baltimore) 1996; 75: 279–285.
10.1097/00005792-199609000-00004
PubMed Web of Science® Google Scholar
3 Nelson KR, McQuillen MP. Neurologic complications of graft-versus-host disease. Neurol Clin 1988; 6: 389–403.
10.1016/S0733-8619(18)30877-6
PubMed Web of Science® Google Scholar
4 George B, Danda D, Chandy M, Srivastava A, Mathews V. Polymyositis–an unusual manifestation of chronic graft-versus-host disease. Rheumatol Int 2001; 20: 169–170.
10.1007/s002960000091
CAS PubMed Web of Science® Google Scholar
5 Sullivan KM, Shulman HM, Storb R, et al. Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression. Blood 1981; 57: 267–276.
10.1182/blood.V57.2.267.267
CAS PubMed Web of Science® Google Scholar
6 Prussick R, Brain MC, Walker IR, Sauder DN. Polymyositis: a manifestation of chronic graft-versus-host disease. J Am Acad Dermatol 1991; 25: 560–562.
10.1016/0190-9622(91)70240-3
PubMed Web of Science® Google Scholar
7 Adams C, August CS, Maguire H, Sladky JT. Neuromuscular complications of bone marrow transplantation. Pediatr Neurol 1995; 12: 58–61.
10.1016/0887-8994(94)00097-L
PubMed Google Scholar
8 Anderson BA, Young PV, Kean WF, et al. Polymyositis in chronic graft vs host disease. A case report. Arch Neurol 1982; 39: 188–190.
10.1001/archneur.1982.00510150058015
PubMed Google Scholar
9 Stevens AM, Sullivan KM, Nelson JL. Polymyositis as a manifestation of chronic graft-versus-host disease. Rheumatology (Oxford) 2003; 42: 34–39.
10.1093/rheumatology/keg025
CAS PubMed Web of Science® Google Scholar
10 Bohan A, Peter JB. Polymyositis and dermatomyositis (second of two parts). N Engl J Med 1975; 292: 403–407.
10.1056/NEJM197502202920807
CAS PubMed Web of Science® Google Scholar
11 Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Engl J Med 1975; 292: 344–347.
10.1056/NEJM197502132920706
CAS PubMed Web of Science® Google Scholar
12 Guglielmi C, Arcese W, Dazzi F, et al. Donor lymphocyte infusion for relapsed chronic myelogenous leukemia: prognostic relevance of the initial cell dose. Blood 2002; 100: 397–405.
10.1182/blood.V100.2.397
CAS PubMed Web of Science® Google Scholar
13 Silberstein L, Davies A, Kelsey S, et al. Myositis, polyserositis with a large pericardial effusion and constrictive pericarditis as manifestations of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation and subsequent donor lymphocyte infusion. Bone Marrow Transplant 2001; 27: 231–233.
10.1038/sj.bmt.1702775
CAS PubMed Web of Science® Google Scholar
14 Porter DL, Roth MS, McGarigle C, Ferrara JL, Antin JH. Induction of graft-versus-host disease as immunotherapy for relapsed chronic myeloid leukemia. N Engl J Med 1994; 330: 100–106.
10.1056/NEJM199401133300204
CAS PubMed Web of Science® Google Scholar
15 Kolb HJ, Schattenberg A, Goldman JM, et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Bloodand Marrow Transplantation Working Party Chronic Leukemia. Blood 1995; 86: 2041–2050.
CAS PubMed Web of Science® Google Scholar
16 Moller E, Bohme J, Valugerdi MA, et al. Speculations on mechanisms of HLA associations with autoimmune diseases and the specificity of autoreactive T lymphocytes. Immunol Rev 1990; 118: 5–19.
10.1111/j.1600-065X.1990.tb00811.x
PubMed Web of Science® Google Scholar
17 Couriel DR, Beguelin GZ, Giralt S, et al. Chronic graft-versus-host disease manifesting as polymyositis: an uncommon presentation. Bone Marrow Transplant 2002; 30: 543–546.
10.1038/sj.bmt.1703711
CAS PubMed Web of Science® Google Scholar
18 Goldstein R, Duvic M, Targoff IN, et al. HLA-D region genes associated with autoantibody responses to histidyl-transfer RNA synthetase (Jo-1) and other translation-related factors in myositis. Arthritis Rheum 1990; 33: 1240–1248.
10.1002/art.1780330826
CAS PubMed Web of Science® Google Scholar

Acute polymyositis after donor lymphocyte infusion

Abstract

References

Citing Literature