2.1. Donor Evaluation

Our donor is a 68-year-old female with a past medical history of hypothyroidism and an extensive past surgical history that included a hysterectomy, small bowel resection with adhesiolysis, partial right colectomy, an incisional hernia repair, and a subsequent small bowel obstruction requiring resection with an inadvertent injury to the right ureter.

In December 2020, she presented to the emergency department with a 2-day history of abdominal pain, nausea, and bilious emesis concerning a small bowel obstruction. She was taken for a diagnostic laparoscopy followed by resection on December 18, 2020. She was left with an open abdomen and had a second look with bowel anastomosis the following day. On the 27th, fever and leukocytosis prompted an infectious workup. A subsequent CT showed right lower quadrant retroperitoneal collection concerning an abscess or urinoma measuring up to 16.7 cm. A ureterogram demonstrated damage to the distal ureter approximately 7 cm proximal to the ureteral orifice. Reconstruction was attempted; however, it was unsuccessful. The following day, a nephrostomy tube was placed.

Prior to proceeding with the donation, the patient underwent a thorough evaluation by the urology team. Alternative procedures were explored but deemed unsuitable due to her surgical history. Both ureteroureterostomy and nephrectomy with kidney autotransplantation were weighed alongside the risks of further surgery in the context of the extensive adhesions. Due to her extensive surgical history, surgical risks associated with adhesions, such as prolonged operative times required for careful dissection of the adhesions, increased risk of injury to abdominal organs due to the obscured surgical field, and increased risk of future intestinal obstruction, were outlined to the patient and carefully considered in regards to future surgical options [4]. Finally, after evaluating the risks and benefits, the patient expressed a preference for nephrectomy. Her renal function was deemed adequate based on nuclear medicine testing. She presented to our clinic for an extensive donor evaluation and was deemed an appropriate candidate with no contraindications. Assessment of preoperative imaging, as shown in Figure 1, demonstrated appropriate renal morphology and vascularity for donation. Ultimately, the patient’s preference to avoid a longer hospital stay with a higher rate of complications, along with the medical team’s assessment of adequate kidney function in her remaining kidney, led us to pursue nephrectomy as the least invasive and most viable option. Using the ESRD Risk Tool for Kidney Donor Candidates, we calculated this patient’s lifetime risk of developing ESRD postdonation to be less than 1% [5]. This low risk is attributed to her favorable health profile, including the absence of hypertension (HTN) and diabetes, a healthy body mass index, and adequate baseline kidney function. The absence of these risk factors significantly reduces her likelihood of kidney disease progression compared to individuals with comorbidities or suboptimal health. Although kidney donation slightly increases the relative risk of ESRD due to the loss of one kidney, her absolute risk remains minimal given her optimal health status. The patient met all institutional medical, surgical, and psychosocial criteria and then underwent an open right nephrectomy without complications.

2.2. Recipient Evaluation

We initially sought a recipient to initiate a kidney donation chain, as is commonly practiced with altruistic kidney donations at our institution. However, given the anticipated challenges of short vascular structures and ureters from the donor, we prioritized identifying a smaller recipient. This approach was aimed at optimizing the compatibility of the donor kidney and minimizing the risk of surgical complications for the recipient.

Our recipient is a 56-year-old woman with a past medical history of diabetes and HTN-induced ESRD diagnosed in 2019. She presented to the clinic for transplant evaluation and was subsequently listed in August 2020. She underwent a thorough evaluation to assess her suitability as a kidney transplant recipient. Her medical and surgical history, psychosocial factors, and immunological compatibility were considered. Her serum creatinine level was 6.8 mg/dL preoperatively, and she was dependent on dialysis three times per week.

2.3. Surgical Procedure

The procedure was initiated with a laparoscopic approach with a standard right donor nephrectomy technique. The donor was placed in a modified lateral decubitus position, and a laparoscopic 12 mm port at the umbilicus was inserted to be used as a camera port. This allowed for visualization of anticipated adhesions due to the extensive past surgical history in the donor and preoperative assessments. The port placement allowed for visual confirmation of the significant adhesions that precluded a laparoscopic approach, and the procedure was converted to open laparotomy without complication. Two renal arteries and one vein were taken with a vascular stapler. Subsequently, the kidney was flushed and handed to the recipient team. A ventral hernia repair was performed before closing. The transplantation procedure was completed without complication.

3.1. Postoperative Course

Our recipient received institution-standard immunosuppressive induction. She had an episode of antibody-mediated rejection that was treated with plasma exchange and intravenous immunoglobulin. Creatinine was stable at 2.3 mg/dL upon discharge on postoperative Day 17. Our donor had an uncomplicated postoperative course and was discharged on postoperative Day 4. She was seen in the clinic with adequate creatinine clearance and excellent quality of life.