EFEMP1 rare variants cause familial juvenile-onset open-angle glaucoma

Human Mutation, 43, 240–252 (2022) https://doi.org/10.1002/humu.24320

The authors and editors wish to correct this article with regard to some revisions made by the authors which were approved by the editors but were not present in the published version of record. The text revisions also include two references which were unintentionally omitted from the original published article and which are included here.

In the first paragraph of Section 1 Introduction on page 241, the sentence beginning “Most adult-onset cases…” should read as follows:

“Most adult-onset cases exhibit complex inheritance with polygenic effects (Wiggs & Pasquale, 2017; Craig et al., 2020).”

In the second paragraph of Section 1 Introduction on page 241, the sentence beginning “One gene, MYOC…” should read as follows:

“One gene, MYOC (encoding myocilin), can account for disease in 5-6% of European Caucasian early-onset glaucoma families undergoing genetic testing (Allen et al., 2015; Knight et al., 2021).”

In the second to last paragraph of Section 4 Discussion on page 249, the sentence beginning “Currently however…” should read as follows:

“Currently however a molecular diagnosis can only be achieved for approximately 20-25% of childhood or early-onset glaucoma cases based on known genes (Allen et al., 2015; Knight et al., 2021).”