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ChemInform Abstract: Stereoselective Synthesis of (3R,5R)-cis-3-Hydroxy-5-phenylpyrrolidine.
First published: 22 May 2010
Abstract
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ChemInform Abstract
The cis-disubstituted pyrrolidine (IV), a precursor of carbapenems such as meropenem, is prepared from inexpensive starting materials (I) and (V) via a face- and chemoselective hydrogenation of cyclic imine (VII) as the common key intermediate.
