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ChemInform Abstract: N-Hydroxyformamide Peptidomimetics as TACE/Matrix Metalloprotease Inhibitors: Oral Activity via P1′ Isobutyl Substitution.
First published: 23 May 2010
Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract
Eleven tripeptidomimetics like (I) are synthesized and their potential as TNF-α converting enzyme (TACE) and matrix metalloprotease inhibitors in vitro and in vivo is examined. Peptidomimetic (Ia) is further evaluated for its pharmacokinetic properties. Upon intravenous and oral dosing, (Ia) exhibits good half-life and bioavailability.
