Heterocyclic Compounds
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ChemInform Abstract: Trifluoromethyl-Containing 3-Alkoxymethyl- and 3-Aryloxymethyl-2-pyridinones Are Potent Inhibitors of HIV-1 Non-Nucleoside Reverse Transcriptase.
First published: 27 May 2010
Abstract
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ChemInform Abstract
The synthesis of title compounds (VI) (22 examples) and their activity against wild-type and mutant types of HIV-1 non-nucleoside reverse transcriptase are described. Compound (VIb), the most potent derivative, also possesses a potent resistance profile against several clinically meaningful mutant virus strains.
