ChemInform Abstract: Microwave-Assisted Solid-Phase Synthesis of Cephalosporin Derivatives with Antibacterial Activity.
Abstract
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ChemInform Abstract
The reaction of 7-aminocephalosporanic acid (I), adsorbed on basic alumina, with heterocyclic acids (II) under microwave irradiation, affords the N-acylated cephalosporin derivatives (III) in yields higher than those obtained by conventional heating. Some of the products show significant antibacterial properties.