ChemInform Abstract: An Easy Entry to (1S,2S) and (1R,2R)-threo-Ifenprodil.
Abstract
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ChemInform Abstract
A facile and practical synthesis of enantiomerically pure L- and D-threo-ifenprodil [cf. (VII)], key intermediates in the synthesis of amphenicol-type antibiotics, starting from corresponding enantiopure threo-2-aminopropanediols (I) is accomplished.