Volume 31, Issue 51
Natural Products
Full Access

ChemInform Abstract: An Easy Entry to (1S,2S) and (1R,2R)-threo-Ifenprodil.

Sergio Mantegani

Sergio Mantegani

Dep. Chem., Pharmacia & Upjohn SpA, I-20014 Nerviano, Milano, Italy

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Emanuele Arlandini

Emanuele Arlandini

Dep. Chem., Pharmacia & Upjohn SpA, I-20014 Nerviano, Milano, Italy

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Enzo Brambilla

Enzo Brambilla

Dep. Chem., Pharmacia & Upjohn SpA, I-20014 Nerviano, Milano, Italy

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Paolo Cremonesi

Paolo Cremonesi

Dep. Chem., Pharmacia & Upjohn SpA, I-20014 Nerviano, Milano, Italy

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Mario Varasi

Mario Varasi

Dep. Chem., Pharmacia & Upjohn SpA, I-20014 Nerviano, Milano, Italy

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First published: 31 May 2010

Abstract

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ChemInform Abstract

A facile and practical synthesis of enantiomerically pure L- and D-threo-ifenprodil [cf. (VII)], key intermediates in the synthesis of amphenicol-type antibiotics, starting from corresponding enantiopure threo-2-aminopropanediols (I) is accomplished.

chemical structure image

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