ChemInform Abstract: Synthesis of Anellated Analogues of 6-Benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442) Using 1,3-Oxazine-2,4(3H)-diones as Key Intermediates.
Abstract
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ChemInform Abstract
Two new MKC-442 analogues (X) and (XII) with fixed orientation of the phenyl group in the molecule are synthesized and their biological activity is investigated. Key intermediates of the synthesis are the oxazine diones (III) which are obtained via two new strategies. All new compounds are tested for their activity against HIV-1 in MT-4 cells. However, only the compounds (X) and (XII) show activity against HIV-1, but at considerably higher concentrations than the reference compound MKC-442.
