ChemInform Abstract: Anti-Helicobacter pylori Agents. Part 4. 2-(Substituted guanidino)-4-phenylthiazoles and Some Structurally Rigid Derivatives.
Abstract
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ChemInform Abstract
Among a novel series of phenylthiazole compounds, e.g. (I), and structurally rigid derivatives, e.g. (II), phenylalkyl derivatives (Id), (Ie), and (If) show high antimicrobial activity against Helicobacter pylori, that is in case of (If) superior to that of amoxicillin. Alkyl derivative (Ib) shows lower, but significant activity and also exhibits more potent gastric antisecretory activity than ranitidine. Compounds (Ib) and (If) are candidates for further pharmacological evaluation.
