ChemInform Abstract: Synthesis of Some Thiazolyl-Pyrazoline Derivatives and Preliminary Investigation of Their Hypotensive Activity.
Abstract
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ChemInform Abstract
Thirty-nine title derivatives like (III) are synthesized by reacting thiocarbamoylpyrazolines (I) with phenacetylbromide (II). Compounds (I) are obtained by reaction of chalcones with thiosemicarbazide in accordance with a literature method. The hypotensive activities of 13 compounds are evaluated. All of them display appreciable activities. Compounds (III) show increased hypotensive activities.
