Volume 31, Issue 25
Isocyclic Compounds
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ChemInform Abstract: Mild and Regioselective Oxidative Bromination of Anilines Using Potassium Bromide and Sodium Perborate.

Didier Roche

Didier Roche

Process Res. Dev., Novartis Inst. Biomed. Res., East Hanover, NJ 07936, USA

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Kapa Prasad

Kapa Prasad

Process Res. Dev., Novartis Inst. Biomed. Res., East Hanover, NJ 07936, USA

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Oljan Repic

Oljan Repic

Process Res. Dev., Novartis Inst. Biomed. Res., East Hanover, NJ 07936, USA

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Thomas J. Blacklock

Thomas J. Blacklock

Process Res. Dev., Novartis Inst. Biomed. Res., East Hanover, NJ 07936, USA

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First published: 07 June 2010

Abstract

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ChemInform Abstract

Deactivated anilines such as (I) and (IV) can be regioselectively monobrominated using potassium bromide and sodium perborate. The reaction can be accelerated by ammonium molybdate as catalyst.

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