ChemInform Abstract: Stereocontrolled Synthesis of a Novel Pharmacophore of the Tubulin-Depolymerizing Marine Natural Product Spongistatin.
Abstract
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ChemInform Abstract
The stereoselective synthesis of (VI) is achieved in 11 steps starting from commercially available benzyl (R)-glycidyl ether. Key step of the synthesis is the high yielding acid-catalyzed intramolecular acetal formation to give (V). Compound (VI) causes tubulin-depolymerization and exhibits potent cytotoxicity against taxol-resistant and vincristine-resistant human cancer cells.
