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ChemInform Abstract: C6 Substitution of Inosine Using Hexamethylphosphorous Triamide in Conjunction with Carbon Tetrahalide or N-Halosuccinimide.
First published: 08 June 2010
Abstract
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ChemInform Abstract
A new and simple procedure for the preparation of C6-bromo- or chloro-substituted purine analogues from inosine (I) is reported. Interestingly, when the reaction is carried out at room temperature, the dimethyladenosine (IV) is formed as the major product.
