ChemInform Abstract: An Investigation of Imidazole and Oxazole Syntheses Using Aryl-Substituted TosMIC Reagents.
Abstract
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ChemInform Abstract
Aryl-substituted tosylmethyl isocyanides readily undergo cycloadditions with a variety of imines generated in situ to give 1,4,5-trisubstituted as well as 1,4- and 4,5-disubstituted imidazoles in one pot. The method can easily accommodate chiral amines and aldehydes to generate products with excellent retention of chiral purity. The cycloaddition of the aryl-substituted tosylmethyl isocyanides with aldehydes generates smoothly oxazoles.
