Preparative Organic Chemistry
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ChemInform Abstract: Effective Ring-Opening Reaction of Aziridines with Trimethylsilyl Compounds: A Facile Access to β-Amino Acids and 1,2-Diamine Derivatives.
First published: 08 June 2010
Abstract
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ChemInform Abstract
In the presence of catalytic tetrabutylammonium fluoride, aziridines undergo regioselective ring-opening with trimethylsilyl compounds to yield azido-, cyano-, or chloroamines. The products can be transformed to derivatives [cf. (III)] of vicinal diamines or β-amino acid esters [cf. (VIII)].
