Volume 31, Issue 16
Natural Products
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ChemInform Abstract: The Efficient Entry into the Tricyclic Core of Halichlorine.

Mitsuru Shindo

Mitsuru Shindo

Inst. Med. Resour., Univ. Tokushima, Shomachi, Tokushima 770, Japan

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Yu-ichi Fukuda

Yu-ichi Fukuda

Inst. Med. Resour., Univ. Tokushima, Shomachi, Tokushima 770, Japan

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Kozo Shishido

Kozo Shishido

Inst. Med. Resour., Univ. Tokushima, Shomachi, Tokushima 770, Japan

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First published: 09 June 2010

Abstract

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ChemInform Abstract

The synthesis of the tricyclic core (V) of halichlorine starts from Grigg′s tricyclic isoxazolidine (II), which is easily available by tandem intramolecular Michael addition—[3 + 2] cycloaddition of the oxime of (I).

chemical structure image

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