ChemInform Abstract: Synthesis and Reactivity of 1,2,4-Triazolo[1,5-c]quinazolines.
Abstract
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ChemInform Abstract
A novel method for the preparation of triazoloquinazolines (III) via cyclocondensation of 3-amino-4-iminoquinazoline derivatives (I) with carboxylic acids or anhydrides (II) is described. The obtained compounds (III) smoothly and efficiently react with secondary amines (IV) as well as hydrazine to furnish the corresponding 5-substituted triazoloquinazolines (V) and (VI), respectively. Hydrazine derivative (VI) proves to be a suitable precursor for the synthesis of novel tetracyclic ring systems (VII) and (VIII).
