ChemInform Abstract: Synthesis of Mono-, Di-, and Triaminosubstituted Pyrimidine Derivatives.
Abstract
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ChemInform Abstract
A series of title compounds, e.g. (IV)—(XI), is synthesized by successive reaction of key intermediates (II) with amines, e.g. (III), as described for the first substitution. Evaluation of their cyclin-dependent kinase inhibitory effect in comparison to flavopiridol as reference compound shows that most of them have little inhibitory activity except compounds (VIIb) and (IX).
