ChemInform Abstract: Synthesis and in vitro Anti-Mycobacterium Activity of N-Alkyl-1,2-dihydro-2-thioxo-3-pyridinecarbothioamides. Preliminary Toxicity and Pharmacokinetic Evaluation.
Abstract
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ChemInform Abstract
Compound (Ic) displays the best in vitro activity among a series of title compounds, e.g. (I), versus Mycobacterium tuberculosis (MT) and Mycobacterium avium complex (MAC), expressed as MICs. Furthermore, the biological results show a remarkable activity for compounds (IIa) and (IId) against MT, but they have no suitable properties for oral or parenteral administration. Thus, further studies are necessary, focused on the development of new potential therapeutic agents against disseminated infections with MT and MAC in patients with advanced acquired human immunodeficiency syndrome (AIDS).
