Isocyclic Compounds
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ChemInform Abstract: A Convenient Method for the N-Acylation and Esterification of Hindered Amino Acids: Synthesis of Ultra Short Acting Opioid Agonist, Remifentanil.
First published: 09 June 2010
Abstract
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ChemInform Abstract
An easily performed sequence allows the conversion of α-amino acids of type (I) to N-acylamino acid esters (IV), isolated as oxalates. Derivative (IVa) is a valuable precursor of remifentanil (VII).
