Volume 31, Issue 12
Isocyclic Compounds
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ChemInform Abstract: Practical and Efficient Chlorination of Deactivated Anilines and Anilides with NCS in 2-Propanol.

Atsuhiko Zanka

Atsuhiko Zanka

Technol. Dev. Lab., Fujisawa Pharm. Co., Ltd., Yodogawa, Osaka 532, Japan

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Ariyoshi Kubota

Ariyoshi Kubota

Technol. Dev. Lab., Fujisawa Pharm. Co., Ltd., Yodogawa, Osaka 532, Japan

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First published: 09 June 2010

Abstract

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ChemInform Abstract

Deactivated anilines (I) and (III) and amides (V) are selectively monochlorinated with NCS in isopropanol. In situ generated isopropyl hypochlorite is suggested as chlorinating agent.

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